B.Sc. (ECUST, Shanghai); Ph.D. (HKU)

Honorary Assistant Professor, Department of Anaesthesiology, The University of Hong Kong

Office : L10-54, Laboratory Block, 21 Sassoon Road, Hong Kong

Tel : (852) 3917-9536 (O); (852) 3917-9786 (Lab)

E-mail : jessie11@hku.hk

HKU Researcher Page : rp02546

ORCID : orcid.org/0000-0002-9307-2235

RESEARCH INTERESTS

• Molecular understanding of pain
• Human stem cell therapy for neurological disorder
• Signaling mechanisms in peripherial nervous system development

PUBLICATIONS

• Liu JA, Jing Y and Cheung CW. Immune actions on the peripheral nervous system in pain. Int J Mol Sci 2021; 22(3): 1448.
• Yang XY, Hu F, Liu JA, Shan Y, Cheung MPL, Liu XL, Ng OL, Guan XY, Wong KKW, Sharma R, Lung HL, Jiao Y, Lee LTO and Cheung M. Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative actiation of MMP9 expression in melanoma. Oncogene 2020; 39(20): 4061-76.
• Liu JA, Tai A, Hong JL, Cheung MPL, Sham MH, Cheah KSE, Cheung CW and Cheung M. Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization. Proc Natl Acad Sci USA 2020; 117(8): 4199-4210.
• Yang XY, Liang R, Liu CX, Liu JA, Cheung MPL, Liu XL, Man OY, Guan XY, Lung HL and Cheung M. SOX9 is a dose-dependent metastatic fate determinant in melanoma. Journal of Experimental & Clinical Cancer Research 2019; 38(1): 17.
• Wang YX, Liu JA, Leung KH, Sham MH, Chan D, Cheah KSE and Cheung M. Reprogramming of mouse calvarial osteoblasts into induced pluripotent stem cells. Stem Cells International 2018; 2018: 5280793.
• Liu JA, Rao Y, Cheung MPL, Hui MN, Wu MH, Chan LK, Ng IO, Niu B, Cheah KSE, Sharma R, Hodgson L and Cheung M. Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration. Nature Communications 2017; 8(1):  1185.
• Liu JA and Cheung M. Neural crest stem cells and their potential therapeutic applications. Developmental Biology 2016; 419(2): 199-216.
• Liu JA, Lai PL, Gui HS, Sham MH, Garcia-Barcelo, MM, Hui CC, and Ngan ES. Identification of GLI mutations in patients with Hirschsprung disease that disrupt enteric nervous system development in mice. Gastroenterology 2015; 149(7): 1837-48.
  (Editor comment: Yong HM, Stamp LA and Hofstra RM. Hirschsprung disease and activation of hedgehog signaling via GLI1-3 mutations. Gastroenterology 2015; 149(7): 1672-5.)
• Lau ST, Zhou TW, Liu JA, Fung EY, Che CM, Lang BH and Ngan ES. Dysregulation of Clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. BBA Molecular Basis of Disease 2015; 1852(8): 1676-86.
• Liu JA and Ngan ES. Hedgehog and Notch signaling in enteric nervous system development. Neurosignals 2014; 22: 1-13.
• Liu JA, Wu MH, Yan CH, Chau BK, So H, Ng A, Chan A, Cheah KS, Briscoe J and Cheung M. Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. Proc Natl Acad Sci USA 2013; 110(8): 2882-7.

    Grants

• RGC General Research Fund (GRF) 2019-2020
• Health and Medical Research Fund (HMRF) 2018

• Faculty Outstanding Research Output Award, Faculty of Medicine, HKU (2019) – in the capacity of first author
• Hong Kong Young Scientist Award (Life Sciences), Hong Kong Institution of Science (2016)
• Award of the Outstanding Research Postgraduate, Department of Surgery, Faculty of Medicine (2015)