MBBS (Sydney); BSc(Med); MD (HKU); FANZCA; FHKCA; FHKAM(Anaesthesiology)

Clinical Associate Professor

Honorary Consultant in Department of Anaesthesiology, Queen Mary Hospital

Assistant Dean (Professional Development), Li Ka Shing Faculty of Medicine, The University of Hong Kong

Honorary Associate Professor, Department of Pharmacology and Pharmacy, The University of Hong Kong

Programme Director, Bau Institute of Medical and Health Sciences Education (Innovation and Collaboration)

E-mail : gordon@hku.hk

Office : K424, Queen Mary Hospital

HKU Researcher Page : rp00523

ORCID : orcid.org/0000-0002-8127-4593

 

RESEARCH INTERESTS

• Perioperative organ preconditioning and protection
• Perioperative medicine
• Effect of anaesthesia on neuronal function and cognition

 

SELECTED PUBLICATIONS

Anaesthesia and Neuroinflammation

Liu Y, Chu JMT, Yan T, Zhang Y, Chen Y, Chang RCC*, Wong GTC*. Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice. J Neuroinflammation 2020; 17(1): 4.

Liu Y, Yan T, Chu JM, Chen Y, Dunnett S, Ho YS, Wong GTC*, Chang RCC*. The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Lab Invest 2019; 99(7): 943-57.

Huang C, Ng OT, Chu JM, Irwin MG, Hu X, Zhu S, Chang RCC*, Wong GTC*. Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice. Neurosci Lett 2019; 707: 134309.

Chu JMT, Xiong W, Linghu KG, Liu Y, Zhang Y, Zhao GD, Irwin MG, Wong GTC*, Yu H*. Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation and Neuroinflammation. Exp Neurobiol 2018; 27(6): 564-73.

Huang CX, Chu JMT, Liu Y, Chang RCC*, Wong GTC*. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology 2018; 143: 217-27.

Huang CX, Irwin MG, Wong GTC*, Chang RCC*. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. Neuroinflammation 2018; 15(1): 147.

Chu JMT, Lee DKM, Wong DPK, Wong GTC*, Yue KKM*. Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals. Metab Brain Dis 2016; 31(5): 1055-64.

Huang CX, Ng TW, Ho YS, Irwin MG, Chang RCC*, Wong GTC*. Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control. J Alzheimers Dis 2016; 51(5): 213-26.

Huang, CX, Ho YS, Ng TW, Irwin MG, Chang RCC*, Wong GTC*. Dexmedetomidine Directly Increases Tau Phosphorylation. J Alzheimers Dis 2015; 44(3): 839-50. 

Perioperative Cardioprotection

Chen K, Yu J, Wang Q, Wu L, Liu X, Wong GTC, Lu Y. The Timing of Propofol administration Affects the Effectiveness of Remote Ischemic Preconditioning Induced Cardioprotection in Rats. J Cell Biochem 2020; 121(11): 4535-41. 

Qiao S, Mao X, Wang Y, Lei S, Liu Y, Wang T, Wong GTC, Cheung CW, Xia Z, Irwin MG. Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats. Crit Care Med 2016; 44(3): e131-45.

Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GTC, Irwin MG, Xia Z. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond) 2015; 129(4): 331-44.

Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GTC, Hung V, Cheung CW, Fang X, Clanachan AS, Xia Z. Propofol Ameliorates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction via Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Rats. Crit Care Med 2014; 42(8): e583-94.

Lu Y, Hu J, Zhang Y, Dong CS, Wong GTC. Remote intrathecal morphine preconditioning confers cardioprotection via spinal cord nitric oxide/cyclic guanosine monophosphate/protein kinase G pathway. J Surg Res 2015; 193(1): 43-51.

Clinical Studies

Cheung V, Yuen VM, Wong GTC, Choi SW. The effect of sleep deprivation and disruption on DNA damage and health of doctors. Anaesthesia 2019; 74(4): 434-40.

Choi SW, Leung FKL, Lau TW, Wong GTC*. Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative management. Hip Int 2019; 29(2): 172-6.

Lu Y, Dai WC, Zong Z, Xiao Y, Wu DI, Liu X, Wong GTC. Bronchial Blocker Versus Left Double-Lumen Endotracheal Tube for One-Lung Ventilation in Right Video-Assisted Thoracoscopic Surgery. J Cardiothorac Vasc Anesth 2018; 32(1): 297-301.

Hou YY, Li Y, He SF, Song J, Yu DX, Wong GTC, Zhang Y. Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design. J Clin Anesth 2017; 41: 21-8.

Scott HB, Choi SW, Wong GTC, Irwin MG. The effect of remifentanil on propofol requirements to achieve loss of response to command vs. loss of response to pain. Anaesthesia 2017; 72(4): 479-87

*denotes corresponding author