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Laboratory

ASSOCIATE PROFESSOR & DEPUTY LABORATORY DIRECTOR
Dr. XIA, Zheng-yuan (夏正遠)
MBMed (Xianning); M.Sc. (Clin. Pharm.); Ph.D. (Brit. Colum.)

Associate Professor, Department of Anaesthesiology, The University of Hong Kong

Member of American Society for Pharmacology & Experimental Therapeutics (ASPET)

Member of Society of Cardiovascular Anesthesiologists (SCA)

Member of International Anesthesia Research Society (IARS)

Office : L10-54, Laboratory Block, 21 Sassoon Road, Hong Kong

Tel : (852) 3917-9794 (O); (852) 3917-9786 (Lab)

E-mail : zyxia@hku.hk

HKU Researcher Page : rp00532

ORCID : orcid.org/0000-0001-6844-5928
RESEARCH INTERESTS
  • Antioxidant treatments for myocardial ischemia-reperfusion injury
  • Pharmacological (anesthetic) preconditioning and postconditioning
  • Reactive oxygen species signalling in diabetic cardiomyophathy
PUBLICATIONS
Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N*, Yao S* and Xia Z*. Cardiac Protective Effects of Remote Ischaemic Preconditioning in Children Undergoing Tetralogy of Fallot Repair Surgery: A Randomized Controlled Trial. Eur Heart J 2018 Apr; 39:1028-37.

Ge M, Yao W, Yuan D, Zhou S, Chen X, Zhang Y, Li H, Xia Z* and Hei Z*. Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury. Cell Death Dis 2017 Jun; 8:e2841.

Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG and Xia Z*. Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats. Diabetes 2016 Apr; 65:942-55. (with editorial: Diabetes 2016 Apr; 65(4):826-8).

Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L and Xia Z*. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med 2015 Jul; 84:311-21.

Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GT, Irwin MG* and Xia Z*. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond) 2015 Aug; 129(4):331-44.

Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GT, Hung V, Cheung CW, Fang X, Clanachan AS and Xia Z*. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats. Crit Care Med 2014 Aug; 42:e583-94. [Published with an editorial]

Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GT, Vanhoutte PM, Irwin MG* and Xia Z*. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med 2013 Oct; 63:291-03.

Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng KF, Lau WB, Ma XL, Rodrigues B, Irwin MG* and Xia Z*. Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing Caveolin-3 expression and Akt/eNOS signaling. Diabetes 2013; 62(7):2318-28. [Featured by “World Biomedical Frontiers: http://biomedfrontiers.org/diabetes-2013-11-29]

Huang Z, Zhong X, Irwin M, Ji S, Wong GT, Liu Y, Xia ZY, Finegan BA and Xia Z*. Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients. Clin Sci (Lond) 2011; 121(2):57-69.

Xia Z*, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J and McNeill JH.  N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovasc Res 2007; 73(4):770-82.

Xia Z*, Huang Z and Ansley DM. Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane. Anesth Analg 2006; 103(3):527-32.
[Note: Cited by: 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons]

Xia Z, Godin DV and Ansley DM. Propofol Enhances Ischemic Tolerance of Middle-aged Rat Hearts: Effects on 15-F2t-isoprostane formation and tissue antioxidant capacity. Cardiovasc Res 2003; 59(1):113-21.

Funding Sources

RGC General Research Fund: GRF 781109 (09/2009-08/2012); GRF 782910 (09/2010-08/2013); GRF 784011 (09/2011-08/2014); GRF 17124614 (09/2014-08/2017); GRF 17123915M (09/2015-08/2018); GRF 17158616M (09/2016-08/2019); GRF 17123718 (09/2018-08/2021); GRF 17118619 (01/2020-12/2022)

Health and Medical Research Fund: HMRF 05161826 (08/2018-07/2020)

National Natural Science Foundation of China (NSFC): NSFC 81270899 (00/2013-12/1016)); NSFC 81970247 (01/2020-12/2023)

Society of Cardiovascular Anesthesiologists: SCA Research Starter and Mid-Career Grant (07/2008-06/2010)