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Laboratory

ASSOCIATE PROFESSOR & DEPUTY LABORATORY DIRECTOR
Dr. XIA, Zheng-yuan (夏正遠)
MBMedXianning; MSc(Clin. Pharm.); Ph.D. (Brit. Colum.)

Associate Professor, Department of Anaesthesiology, The University of Hong Kong

Member of American Society for Pharmacology & Experimental Therapeutics (ASPET)

Member of Society of Cardiovascular Anesthesiologists (SCA)

Member of International Anesthesia Research Society (IARS)

Office : L10-54, Laboratory Block, 21 Sassoon Road, Hong Kong

Tel : (852) 3917-9794 (O); (852) 3917-9786 (Lab)

E-mail : zyxia@hku.hk

HKU Researcher Page : http://hub.hku.hk/rp/rp00532

ORCID : http://orcid.org/0000-0001-6844-5928
RESEARCH INTERESTS
  • Antioxidant treatments for myocardial ischemia-reperfusion injury
  • Pharmacological (anesthetic) preconditioning and postconditioning
  • Reactive oxygen species signalling in diabetic cardiomyophathy
PUBLICATIONS
Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N*, Yao S* and Xia Z*. Cardiac Protective Effects of Remote Ischaemic Preconditioning in Children Undergoing Tetralogy of Fallot Repair Surgery: A Randomized Controlled Trial Eur Heart J. 2018 Apr;39:1028-37.

Ge M, Yao W, Yuan D, Zhou S, Chen X, Zhang Y, Li H, Xia Z* and Hei Z*. Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury Cell Death Dis. 2017 Jun; 8:e2841.

Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG, and Xia Z*. Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats Diabetes. 2016 Apr; 65:942-55. (with editorial: Diabetes. 2016 Apr;65(4):826-8)

Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z*. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med. 2015 Jul;84:311-21.

Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GT, Irwin MG*, Xia Z*. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond). 2015 Aug;129(4):331-44.

Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GT, Hung V, Cheung CW, Fang X, Clanachan AS, Xia Z*. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats. Crit Care Med. 2014 Aug;42:e583-94.(Published with an editorial)

Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GT, Vanhoutte PM, Irwin MG*, Xia Z*. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med. 2013 Oct;63:291-03.

Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng KF, Lau WB, Ma XL, Rodrigues B, Irwin MG*, Xia Z*. Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing Caveolin-3 expression and Akt/eNOS signaling. Diabetes. 2013;62(7):2318-28. (Featured by “World Biomedical Frontiers: http://biomedfrontiers.org/diabetes-2013-11-29)

Huang Z, Zhong X, Irwin M, Ji S, Wong GT, Liu Y, Xia ZY, Finegan BA, Xia Z*. Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients. Clin Sci (Lond). 2011;121(2):57-69.

Xia Z*, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J and McNeill JH.  N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovasc Res. 2007;73(4):770-82.

Xia Z*, Huang Z and Ansley DM. Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane. Anesth Analg. 2006;103(3):527-32.
(Note: Cited by: 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons)

Xia Z, Godin DV, and Ansley DM. Propofol Enhances Ischemic Tolerance of Middle-aged Rat Hearts: Effects on 15-F2t-isoprostane formation and tissue antioxidant capacity. Cardiovasc Res. 2003;59(1):113-21.

Funding Sources

RGC General Research Fund: GRF 781109 (09/2009-08/2012); GRF 782910 (09/2010-08/2013); GRF 784011 (09/2011-08/2014); GRF 17124614 (09/2014-08/2017); GRF 17123915M (09/2015-08/2018); GRF 17158616M (09/2016-08/2019); GRF 17123718 (09/2018-08/2021)

Health and Medical Research Fund: HMRF 05161826 (08/2018-07/2020)

National Natural Science Foundation of China (NSFC): NSFC 81270899 (00/2013-12/1016)

Society of Cardiovascular Anesthesiologists: SCA Research Starter and Mid-Career Grant (07/2008-06/2010)