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2019

Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, et al.  Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine.  Br J Anaesth 2019; 122(5): 542-51.  

Chan SP, Ip KY and Irwin MG.  Peri-operative optimization of elderly and frail patients: a narrative review.  Anaethesia 2019; 74 (S1): 80-9. 

Chen K, Wang L, Wang Q, Liu X, Lu Y, Li Y and Wong GTC.  Effects of pneumoperitoneum and steep Trendelenburg position on cerebral hemodynamics during robotic-assisted laparoscopic radical prostatectomy: a randomized controlled study.  Medicine 2019; 98(21): e15794. 

Cheung VYT, Lam TPW, Jenkins CR, Lam SW, Cheung GKI, Chan SSY and Choi WK. Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine fibroids: a preliminary experience.  J Obstet Gynaecol 2019; 39(6): 833-9. 

Chow LWC, Cheng KS, Leong F, Cheung CW, Shiao LR, Leung YM and Wong KL. Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production. Naunyn Schmiedebergs Arch Pharmacol 2019; 392(4): 427-36.

Huang C, Ng OT, Chu JM, Irwin MG, Hu X, Zhu S, Chang RC and Wong GT.  Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice.  Neurosci Lett 2019; 707: 134309.

Irwin MG and Wong GTC.  Taking on TIVA. Why we need guidelines on total intravenous anaesthesiaAnaesthesia 2019; 74(2): 140-2.

Lee LKK, Tsai NWP, Ip KY and Irwin MG.  Pre-operative cardiac optimization: a directed review. Anaesthesia 2019; 74(S1): 67-9. 

Liu Y, Paterson M, Baumgardt SL, Irwin MG, Xia Z, Bosnjak ZJ and Ge ZD. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning. Cardiovasc Res 2019; 115(1):168-78.   

McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F et al. Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122(5): 575-86. 

Sanders RD, Hughes F, Shaw A, Thompson A, Bader A et al. Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery.  Br J Anaesth 2019; 122(5): 552-62. 

Sessier DI, Blookstone JA, Aronson S, Berry C, Gan T et alPerioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122(5): 563-74. 

Shi DD, Huang YH, Lai CSW, Dong CM, Ho LC, Li XY, Wu EX, Li Q, Wang XM, Chen YJ, Chung SK and Zhang Z. Ginsenoside Rg1 prevents chemotherapy-induced cognitive impairment: associations with microglia-mediated cytokines, neuroinflammation, and neuroplasticity. Mol Neurobiol 2019; 56(8): 5626-42. 

Tsai NW, Leung YM, Ng PY. Liong T, Lee SF, Ngai CW, Sin WC, Koo J and Chan WM.  Attitudes of visitors at adult intensive care unit toward organ donation and organ support. Chin Med J (Engl) 2019; 132(3): 373-6.

Ward PA and Irwin MG.  Airway management research and the need for consensus. Anaesthesia 2019; 74(7): 942. 

Wong SCS, Lee UM, Wang XMA, Chung SK and Cheung CW. Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.  Neurosci Lett 2019; 709: 134379.

Wong SCS, Leung MYY and Cheung CW. The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trial. Eur J Pain 2019; 23(5):  884-93. 

Wong SCS, Sun LT, Qiu Q, Gu P, Li Q, Wang XMA and Cheung CW.  Propofo attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.  Eur J Pain 2019; 23(4): 812-22. 

Xiong W, Zhao GD, Yin X, Linghu KG, Chu MT, Wong GTC, Li H, Yu H and Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigations. Carbohydr Polym 2019; 204: 89-96. 

Ye X, Zhang D, Wang S, Irwin MG and Xia Z. Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury. The FASEB J  2019; 33(S1): A514.11.   

Yuen VMY, Cheuk DK, Hui TW, Wong IC, Lam WW and Irwin MG. Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicenter study, Hong Kong Med J 2019; 25(S3): 27-9.

Zhu D, Fan T, Huo X, Cui J, Cheung CW and Xia Z. Progressive increase of inflammatory CXCR4 and TNF-Alpha in the dorsal root ganglia and spinal cord maintains peripheral and central sensitization to diabetic neuropathic pain in rats. Mediators Inflamm 2019; 2019: 4856156.



2018

Chang L, Ye F, Luo Q, Wang Z, Wang Y, Xia Z and Shu H.  Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia.  BioSci Trends. 2018; 12(2): 177-184.  

Chen X, Wang Y, Xie X, Chen H, Zhu Q, Ge Z, Wei H, Deng J, Xia Z and Lian Q.  Heme oxygenase-1 reduces sepsis-induced endoplasmic reticulum stress and acute lung injury.  Mediator Inflam. 2018; 2018: 9413876(1-10).

Choi SW, Charlesworth M and Wong GTC.  A good pilot to navigate troubled waters.  Anaesthesia. 2018; 73(4): 512-4.

Choi SW, Leung FKL, Lau TW and Wong GTC.  Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative management.  HIP Int. 2019(2): 172-6 (Epub 2018 May)

Choi SW and Wong GTC.  Doctor, why are you driving a wedge between us? Calculating sample size in multiple testing and the need for Geisser-Greenhouse correctionAnaesthesia 2018; 73(12): 1564-66.

Choi SW and Wong GTC.  Quality improvement studies - pitfalls of the before and after study design.  Anaesthesia 2018; 73(11): 1432-35.

Choi SW and Wong GTC. Assumptions and associations under pressureAnaesthesia 2018; 73(7): 901-3.

Choi SW and Wong GTC.  The art and science of statistical predictions: does a picture need a thousand words?  Anaesthesia 2018; 73(6): 784-7.

Choi SW and Wong GTC. Before and after studies and historical controls. Is the proof in the pudding?  Anaesthesia 2018; 73(5): 642-4.

Choi SW and Wong GTC.  Big data, big problems: causation, confounders and cohortsAnaesthesia 2018; 73(3): 384-7.

Ge L, Ma H, Cai Y, Pang L, Irwin MG and Xia Z.  MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation.  FASEB J. 2018; 32(1_supp).

Greenland K.B. and Irwin MG.  Big data: breaking new ground in airway research. Anaesthesia. 2018; 73(6): 674-8. 

He Y, Cai Y, Yan D, Zhang D, Chen C, Irwin MG, Wang S and Xia Z.  MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling. FASEB J. 2018; 32(1_supp). 

Ho RHY and Irwin MG.  Anaesthesia for surgery major spinal.  Anaesthe Intensive Care Med. 2018; 19(4): 159-63.

Huang C, Irwin MG, Wong GTC and Chang RCC.  Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.  J Neuroinflammation. 2018; 15(1): 147.

Huang C, Chu JM, Liu Y, Chang RCC and Wong GTC.  Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged miceNeuropharmacology. 2018; 143: 217-27.

Jin SY, Huang J, Zhu HJ, Wu H, XU SJ, Irwin MG, He SF and Zhang Y.  Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heartEur J Pharmacol. 2018; 828: 1-8. 

Kosuru R, Cai Y, Kandula V, Yan D, Wang C, Zheng H, Li Y, Irwin MG, Singh S and Xia Z.  AMPK contributes to cardioprotective effects of pterostilbene against myocardial ischemia- reperfusion injury in diabetic rats by suppressing cardiac oxidative stress and apoptosis. Cell Physiol Biochem. 2018; 46(4): 1381-97.

Kosuru R, Kandula V, Rai U, Prakash S, Xia Z and Singh S.  Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats.  Cardiovasc Drugs Ther. 2018; 32(2): 147163.

Kwok DHY and Irwin MG.  Preoperative assessment of the orthopaedic patient.  Anaesthe Intensive Care Med. 2018; 19(4): 151-4.

Lam WL, Yeung WF, Wong MK, Cheung CW, Chan KKL, Ngan HYS, Wong CKH, Chen H and Lao L.  Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trial. Trials 2018; 19(1): 8.

Lau YC and Irwin MG.  Anaesthesia for joint replacement surgery.  Anaesthe Intensive Care Med. 2018; 19(4): 171-4.

Li A, Yuen VM, Goulay-Dufay S, Sheng Y, Standing JF, Kwok PCL, Leung AS, Wong ICK and Irwin MG.  Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine.  Br J Anaesth. 2018; 120(5): 960-8.

Li H, Irwin MG and Xia Z.  Hyperglycemia-induced protein kinase Cβ2 activation causes diastolic cardiac dysfunction by disrupting Brg1-mediated suppression of RIP3 in diabetic rats.  FASEB J. 2018; 32(1_supp).

Liu J, Yan D, Xie X and Xia Z.  FOXO1 couples reactive oxygen species in diabetic atherosclerosis.  FASEB J. 2018; 32(1_supp). 

Liu Y, Paterson M, Baumgardt SL, Irwin MG, Xia Z, Bosnjak ZJ and Ge ZD.  Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioningCardiovasc Res. 2019; 115(1):168-78. (Epub on 2018)

Lu Y, Dai WC, Zong Z, Xiao Y, Wu DI, Liu X and Wong GTC.  Bronchial blocker versus left double-lumen endotracheal tube for one-lung ventilation in right video-assisted thoracoscopic surgery.  J Cardiothorac Vasc Anesth. 2018; 32(1): 297-301. 

Mu JJ, Jiang T, Deng LP, Choi SW, Irwin MG and Yuen VMY.  A comparison of two techniques for induction of anaesthesia with target-controlled infusion of propofol.  Anaesthesia 2018; 73(12): 1507-14.

Mu J, Jiang T, Xu XB, Yuen VMY and Irwin MG.  Comparison of target-controlled infusion and manual infusion for Propofol anaesthesia in children.  Br J Anaesth. 2018; 120(5): 1049-55.

Pandit JJ and Irwin MG. Difficult airway society guidelines on the airway management of critically ill patients. A reply. Anaesthesia 2018; 73(8): 1036-37.

Pandit JJ and Irwin MG.  Airway management in critical illness: practice implications of new Difficult Airway Society guidelines.  Anaesthesia 2018; 73(5): 544-8.

Shi DD, Ding M, Ho LC, Lam CTW, Zhou XD, Wu EX, Zhou ZJ, Wang XM and Zhanf ZJ.  Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: involvement of cytokine modulation and neuroprotectionNeurobiol Dis. 2018; 114: 164-73.

Smith AS and Irwin MG.  Researching research.  Anaesthesia 2018; 73(6): 668-71.

Tai WL, Pan Z, Sun LT, Li H, Gu P, Wong SCS, Chung SK and Cheung CW,  Suppression of Pax2 attenuates allodynia and hyperalgesia through ET-1–ETAR–NFAT5 signaling in a rat model of neuropathic pain.  Neuroscience 2018; 384: 139-51.

Wong ESW, Man RYK, Ng KFJ, Leung SWS and Vanhoutte PMGR.  L-arginine and arginase products potentiate dexmedetomidine-induced contractions in the rat aorta.  Anesthesiology 2018; 128: 564-73.

Wong GTC.  Patient emergence – statistical questions.  Anaesthesia 2018; 73(1): 130.

Wong GTC, Choi SW, Tran DHD, Kulkarni H and Irwin MG.  An international survey evaluating factors influencing the use of total intravenous anaesthesia.  Anaesth Intensive Care. 2018; 46(3): 332-8.

Wong GTC and Irwin MG.  A cost comparison between total intravenous and volatile anaesthesia.  Anaesth Intensive Care. 2018; 46(6): 633-4.

Wong SCS, Qiu Q and Cheung CW.  Segmental spinal myoclonus complicating lumbar transforaminal epidural steroid injection.  Reg Anesth Pain Med. 2018; 43(5): 554-6.

Wong SCS and Irwin MG.  Anaesthesia and minimally invasive surgery.  Anaesth Intensive Care Med. 2018; 19(1): 11-5.

Wong SCS and Irwin MG.  Procedures under tourniquet.  Anaesthe Intensive Care Med. 2018; 19(4): 155-8.

Wong SCS, Choi SW and Cheung CW.  A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour.  PLoS One 2018; 13(10): e0204054.

Wong SCS, Choi SW, Lee Y, Irwin MG and Cheung CW.  The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery.  Medicine 2018; 97(31): e11615.

Xie X, Yan D, Li H, Zhu Q, Li J, Fang YP, Cheung CW, Irwin MG, Xia Z and Lian Q.  Enhancement of adiponectin ameliorates nonalcoholic fatty liver disease via inhibition of FoxO1 in type I diabetic rats.  J Diabetes Res. 2018; 2018: 6254340(1-9).

Xiong W, Zhao GD, Yin X, Linghu KG, Chu MT, Wong GTC, Li H, Yu H and Wang YT.  Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigations.  Carbohydr Polym. 2019; 204: 89-96. (Epub 2018 Oct)

Yan D, Cai Y, Luo J, Liu J, Irwin MG and Xia Z.  Pharmacologic inhibition of FOXO1 improves cardiac function by enhancing glucose metabolism and attenuating apoptosis in type-1 diabetic rats.  FASEB J. 2018; 32c.

Ye XD, He Y, Wang S, Wong GTC, Irwin MG and Xia Z. Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis. Acta Pharmacol Sin. 2018; 39(7): 1155-63.

You R, Ho YS, Hung HLC, Liu Y, Huang C, Chan HN, Ho SL, Lui SY, Li HW and Chang RCC.  Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation. Part Fibre Toxicol. 2018; 15(1): 28.

Ying F, Cai Y, Tang EHC and Xia Z.  Deficiency of prostaglandin E2 receptor subtype 4 exacerbates left ventricular remodeling and myocardial fibrosis in diet-induced mice.  FASEB J. 2018; 32(1_supp).

Ying F, Cai Y, Wong HK, CHen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A and Tang EHC. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(9): 1029-40. 

Zhang C, Luo Q, Li Y, Wu X, Hao Z, LI S, Xia Z, Yan F and Sun L.  Predictors of short-term outcomes following repair of anomalous origin of the left coronary artery from the pulmonary artery in Chinese children: a case-control studyJ Cardiothorac Vasc Anesth. 2018; 32(6): 2644-51.



2017

Cai Y, Kosuru R, Ye X, Irwin MG and Xia Z. Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. Cell Cycle 2017; 16(19): 1765-73. 

Chan LK, Ganotice FJr, Wong FKY, Lau CS, Bridges SM, Chan CHY, Chan N, Chan PWL, Chen HY, Chen JY, Chu JKP, Ho CC, Ho JMC, Lam TP, Lam VSF, Li Q, Shen JG, Tanner JA, Tso WWY, Wong AKC, Wong GTC, Wong JYH, Wong NS, Worsley A, Yu LK and Yum TP.  Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning.  BMC Med Edu. 2017; 17(1): 221. 

Cheng Y, Feng Y, Xia Z, Li X and Rong J.  ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS.  Biochim Biophys Acta. 2017; 1862(12): 1595-1605. 

Cheung CW, Wong SCS, Qiu Q and Wang XMA.  Oral oxycodone for acute postoperative pain: a narrative review of clinical trials.  Pain Physician. 2017; 20(2S): SE33-SE52. 

Cheung CW, Choi SW, Wong SSC, Lee Y and Irwin MG.  Changes in prevalence, outcomes and help-seeking behavior of chronic pain in an aging population over the last decade.  Pain Practice 2017; 17(5): 643-54. 

Choi SW, Lam DM, Wong SCS, Shiu HC, Wang XMA and Cheung CW.  Effects of Single Nucleotide Polymorphisms on Surgical and Post-surgical Opioid Requirements - A Systematic Review and Meta-analysis. Clin J Pain. 2017; 33(12): 1117-30.

Gao S, Zhan L, Yang Z, Shi R, Li H, Xia Z, Yuan S, Wu QP, Wang T and Yao S.  Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling.  Cell Physiol Biochem. 2017; 43(3): 1140-51.

Greenland KB, Bradley WPL, Chapman GA, Goulding G and Irwin MG.  Emergency front-of-neck access: scalpel or cannula-and the parable of Buridan's ass.  Br J Anaesth. 2017; 118(6): 811-4. 

Greenland KB, Bradley WPL, van Zundert A and Irwin MG.  Airway assessment/management paradigm - does a spectral or a binary approach fit better?  Anaesthesia 2017; 72(8): 1035-37. 

Hou YY, Li Y, He SF, Song J, Yu DX, Wong GTC and Zhang Y.  Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design.  J Clin Anesth. 2017; 41: 21-28. 

Kong KFV, Jian CJ, Ji R and Irwin MG.  Management of an incidental finding of right internal jugular vein agenesis.  Hong Kong Med J. 2017; 23(4): 414-5. 

Li MJ, Li M, Liu Z, Yan B, Pan Z, Huang D, Liang Q, Ying D, Xu F, Yao H, Wang P, Kocher JA, Xia Z, Sham PC, Liu JS and Wang JJ.  cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes.  Genome Biol. 2017; 18(1): 52. 

Lu J, Yao X, Luo X, Wang Y, Chung SK, Tang H, Cheung CW, Wang X, Meng C and Li Q. Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells.  Neural Regen Res. 2017; 12(6): 945-52. 

Qiu Q, Sun L, Wang XM, Lo ACY, Wong K, Gu P, Wong SCS and Cheung CW.  Propofol produces preventive analgesia via GluN2B-containing NMDA Receptor/ERK1/2 signaling pathway in the rat model of inflammatory pain.  Mol Pain. 2017; 13: 1744866917737462. 

Scott HB, Choi SW, Wong GTC and Irwin MG. The effect of remifentanil on propofol requirements to achieve loss of response to command vs. loss of response to painAnaesthesia 2017; 72(4): 479-87. 

Sun LT, Tai L, Qiu Q, Mitchell R, Fleetwood-Walker S, Joosten EAJ and Cheung CW.  Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation.  Eur J Pain. 2017; 21(5): 804-14.  

Tian G, LUO X, Tang C, Cheng X, Chung SK, Xia Z, Cheung CW and Guo Q.  Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome.  Life Sciences 2017; 170: 64-71. 

Veniaminova E, Cespuglio R, Cheung CW, Umriukhin A, Markova N, Shevtsova E, Lesch KP, Anthony DC and Strekalova T.  Autism-like behaviours and memory deficits result from a western diet in mice.  Neural Plast. 2017; 2017: 9498247.

Wang L, Zhou MT, Chen CY, Yin W, Wen DX, Cheung CW, Yang LQ and Yu WF. Increased renal clearance of rocuronium compensates for chronic loss of bile excretion, via upregulation of Oatp2.  Sci Rep. 2017; 7: 40438.

Wong GTC, Ang WC, Wong CLT and Choi SW.  Surgical Outcome Risk Tool (SORT) validation in hepatectomy.  Anaesthesia 2017; 72(10): 1287-89.

Wong SCS, Chan TCW and Cheung CW.  Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice.  Hong Kong Med J. 2017; 23(5): 517-23.

Yao W, Li H, Han X, Chen C, Zhang Y, Tai WL, Xia Z and Hei Z.  MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro.  J Cell Mol Med. 2017; 21(10): 2503-13. 

Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z and Hei Z.  SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction.  Free Radic Biol Med. 2017; 108: 542-53. 

Ying F, Cai Y, Cai Y, Wang Y and Tang EHC.  Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue. FASEB J. 2017; 331(9): 4023-36.

Yuen VMY, Li BL, Cheuk DK, Leung MKM, Hui TWC, Wong IC, Lam WW, Choi SW and Irwin MG.  A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children.  Anaethesia 2017; 72(10): 1191-95.

Yuen VMY, Wong CHP, Wong SCS and Wong GTC.  Rescue oxygenation in small infants.  Anaesthesia 2017; 72(12): 1564-65. 

ZhaoY, Zheng ZN, Cheung CW, Zuo ZY and Jin SQ.  Transfusion of plasma collected at late phase after preconditioning reduces myocardial infarct size induced by ischemia-reperfusion in rats in vivo.  Chin Med J (Engl). 2017; 130(3): 303-8.



2016

Cao S., Liu Y., Wang H., Mao X., Chen J., Liu J., Xia Z., Zhang L., Liu X. and Yu T., Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts, PeerJ. 2016, 4: e1706.

Cheng Y., Xia Z., Han Y. and Rong J., Plant natural product formononetin protects rat cardiomyocyte H9c2 cells against oxygen glucose deprivation and reoxygenation via inhibiting ROS formation and promoting GSK-3β phosphorylation, Oxid Med Cell Longev. 2016, 2016: 2060874. 

Chan A.C., Qiu Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W., Effects of intra-operative total intravenous anaesthesia with Propofol versus inhalational anaesthesia with Sevoflurane on post-operative pain in liver surgery: a retrospective case-control study, PLOS One. 2016, 11: e0149753.

Luo X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W., CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain, Rev Neurosci. 2016, 27(1): 83-92.

Wong S.C.S. and Irwin M.G., Peri-operative cardiac protection for non-cardiac surgery, Anaesthesia. 2016, 71 S1: 29-39.

Cheung C.W., Chan T.C.W., Chen P.P., Chu M.C., Chui W.C.M., Ho P.T., Lam F., Law S.W., Lee J.L.Y., Wong S.H.S. and Wong V.K.C., Opioid therapy for chronic non-cancer pain: guidelines for Hong Kong. Hong Kong Med J. 2016, 22(5): 496-505. 

Cheung C.W., Prescription drug monitoring programs needed to manage opioid use in Asia Pacific, Pain Pract. 2016, 16(5): E93. 

Choi S.W. and Cheung C.W., Don't judge a book by its cover, don't judge a study by its abstract. Common statistical errors seen in medical papers, Anaesthesia. 2016, 71(7): 843-5. 

Choi S.W., Lam D.M. and Irwin M.G., Ghost in the machine, Hong Kong Med J. 2016, 22(3): 292-3. 

Choi S.W. and Wong G.T.C., It's just a standard deviation! Anaesthesia. 2016, 71(8): 969-71. 

Chu M.T., Lee D.K.M., Wong D.P.K., Wong G.T.C. and Yue K.K.M., Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals, Metab Brain Dis. 2016, 31(5): 1055-64. 

Gao S., Yang Z., Shi R., Xu D., Li H., Xia Z., Wu Q.P., Yao S., Wang T. and Yuan S., Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling, Eur J Pharmacol. 2016, 779: 111-21. 

Gao S., Zhu Y., Li H., Xia Z., Wu Q., Yao S., Wang T. and Yuan S., Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation, Int Immunopharmacol. 2016, 38: 395-401. 

Huang C., Ng O.T.W., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion in rat on tau phosphorylation with or without temperature control, J Alzheimers Dis. 2016, 51(1):213-26. 

Han X., Yao W., Liu Z., Li H., Zhang Z.J., Hei Z. and Xia Z., Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner, Oxid Med Cell Longev. 2016, 2016: 9303606. 

Kandula V., Kosuru R., Li H., Yan D., Zhu Q., Lian Q., Ge R.S., Xia Z. and Irwin M.G., Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy, Cardiovasc Diabetol. 2016, 15: 44. 

Li A., Yuen V.M.Y., Dufay S. and Kwok P.C.L., Pharmacokinetics and pharmacodynamics of dexmedetomidine, Drug Dev Ind Pharm. 2016, 42(12):1917-27.

Li B.L., Zhang N., Huang J.X., Qiu Q.Q., Tian H., Ni J., Song X.R., Yuen V.M.Y. and Irwin M.G., A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops, Anaesthesia. 2016, 71(5): 522-8. 

Li H., Yao W., Liu Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z., Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats, Diabetes. 2016, 65(4): 942-55. 

Li M.J., Liu Z., Wang P., Wong M.P., Nelson M.R., Kocher J.P.A., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J., GWASdb v2: an update database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2016, 44(D1): D869-76. 

Lin J., Wang T., Li Y., Wang M., Li H., Xia Z. and Irwin M.G., N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats, J Diabetes Res. 2016, 2016: 9213034.

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, Mol Pain. 2016, 12: 1-15. 

McLintic A.J. and Irwin M.G., Is the injury out on consensus opinion? Anaesthesia. 2016, 71(3): 256-60. 

Pang L., Cai Y., Tang E.H.C., Yan D., Li H., Irwin M.G., Ma H., Xia Z. and Ramoji K., COX-2 inhibition protects against hypoxia/reoxygenation-induced cardiomyocyte apoptosis via Akt-dependent enhancentment of iNOS expression, Oxid Med Cell Longev. 2016, 2106: 3453059.

Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z., Prostaglandin E receptor subtype 4 signaling in the heart: role in ischemia/reperfusion injury and cardiac hypertrophy, J Diabetes Res. 2016, 2016: 1324347.

Qiu Q., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis, Anaesthesia. 2016. 71(10): 1222-33. 

Qiao S., Mao X., Wang Y., Lei S., Liu Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G., Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the janus activated kinase-2/signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3β in rats, Crit Care Med. 2016, 44(3): e131-45. 

Samartzis D., Bow H.Y.C., Cheung J.P.Y., Sham P.L.M., Mak K.C., Cheung W.Y., Wong Y.W., Luk K.D.K., Cheung K.M.C. and Law Min J., Efficacy of postoperative pain management using continuous local anesthetic infusion at the iliac crest bone graft site in patients with adolescent idiopathic scoliosis: a parallel, double-blinded, randomized controlled pilot trialGlobal Spine Journal. 2016, 6(3):220-8.

She W.H., Cheung T.T., Jenkins C.R. and Irwin M.G., Clinical applications of high-intensity focused ultrasoundHong Kong Med J. 2016, 22(4): 382-92. 

Wang Y., Li H., Huang H., Liu S., Mao X., Wang S., Wong S.S.C., Xia Z. and Irwin M.G., Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling, Clin Sci (Lond). 2016, 130(10): 801-12.  

Wang L., Wang T., Li H., Liu Q., Zhang Z., Xie W., Feng Y., Socorburam T., Wu G., Xia Z. and Wu Q., Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice, PLoS One. 2016, 11(5): e0155723. 

Wang Y., Song E., Bai B. and Vanhoutte P.M., Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes, Pharmacol Ther. 2016, 158: 91-100. 

Wong G.T.C., Lee E.Y.P. and Irwin M.G., Contrast induced nephropathy in vascular surgery, Br J Anaesth. 2016, 117(S2): ii63-73. 

Wong S.C.S. and Irwin M.G., Peri-operative cardiac protection for non-cardiac surgery, Anaesthesia. 2016, 71(S1): 29-39. 

Xia Z., Li H. and Irwin M.G., Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans, Br J Anaesth. 2016, 117(S2): ii44-62. 

Xue R., Lei S., Xia Z., Wu Y., Meng Q., Zhan L., Su W., Liu H., Xu J., Liu Z., Zhou B. and Xia Z., Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways, Clin Sci (Lond). 2016, 130(5): 377-92. 

Ye X., He Y., Xia Z. and Wang S., Fetal descending aortic flow and heart rate monitoring with transesophageal echocardiography during maternal cardiac surgery, Can J Anaesth. 2016, 63(4): 492-4. 

Yu EH, Tran DH, Lam SW and Irwin MG.  Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain? Anaesthesia 2016; 71(11): 1347-62.

Zhuang H., Tian W., Li W., Zhang X., Wang J., Yang Y., Liu X., Xia Z., Feng D. and Zhang L., Autophagic cell death and apoptosis jointly mediate cisatracurium besylate-induced cell injury, Int J Mol Sci. 2016, 17(4): 515.



2015

Au A.H.Y., Choi S.W., Cheung C.W. and Leung Y.Y., The efficacy and clinical safety of various analgesic combinations for post-operative pain after third molar surgery: a systematic review and meta-analysis, PLoS One. 2015, 10(6): e0127611.

Cheung A.H.K., Li L.F., So V.C., Leung M.K.M. and Lui W.M., Transient monoplegia and paraesthesia after an epidural blood patch for a spinal cerebrospinal fluid leak, J Clin Neurosci.2015, 22(9): 1493-5.

Cheung C.W., Qiu Q., Liu J., Chu K.M. and Irwin M.G., Intranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial, Acta Anaesthesiol Scand. 2015, 59(2): 215-23.

Hung K.L., Tai W.L., Luo X., Xiao M.W., Chung S.K. and Cheung C.W., Targeted over-expression of astrocytic endothelin-1 attenuates neuropathic pain by up-regulating spinal excitatory amino acid transporter-2, J Mol Neurosci. 2015, 57(1): 90-6.

Chow K.Y., Liu S.E. and Irwin M.G., New therapy in cardioprotection, Curr Opin Anaesthesiol. 2015, 28(4): 417-23.

Gan X., Xing D., Su G., Li S., Luo G., Irwin M.G., Xia Z., Li H. and Hei Z., Propofol attenuates small intestinal ischemia reperfusion injury through inhibiting NADPH oxidase mediated mast cell activation, Oxid Med Cell Longev. 2015, 2015: 167014.

Huang C., Ho Y.S., Ng O.T., Irwin M.G., Chang R.C. and Wong G.T., Dexmedetomidine directly increases tau phosphorylation, J Alzheimers Dis. 2015, 44(3): 839-50.

Irwin M.G. and Wong G.T.C., Remifentanil and opioid-induced cardioprotection, J Cardiothorac Vasc Anesth. 2015, 29(S1): S23-6.

Jiang Y., Zhou Z., Meng Q.T., Sun Q., Su W., Lei S., Xia Z. and Xia Z.Y., Ginsenoside Rb1 treatment attenuates pulmonary inflammatory cytokine release and tissue injury following intestinal ischemia reperfusion injury in mice, Oxid Med Cell Longev. 2015, 2015: 843721.

Lam D.M., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W., Efficacy of pregabalin in acute postoperative pain under different surgical categories: a meta-analysis, Medicine. 2015, 94(46): e1944.

Li H., Yao W., Irwin M.G., Wang T., Wang S., Zhang T. and Xia Z., Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1, Free Radic Biol Med. 2015, 84: 311-21.

Li S., Xu J., Yao W., Li H., Liu Q., Xiao F., Irwin M.G., Xia Z. and Ruan W., Sevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathway, Biochem Biophys Res Commun. 2015, 460(3): 879-86.

Liman S., Cheung C.W., Wong K., Tai W.L., Qiu Q., Ng J.K.F., Choi S.W. and Irwin M.G., Preventive treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postichaemia pain model, Oxid Med Cell Longev. 2015, 2015: 380403.

Liu B., Huang W.H., Xiao X., Yu Y., Ma S. and Xia Z., Neuroprotective effect of ulinastatin on spinal cord ischemia-reperfusion injury in rabbits, Oxid Med Cell Longev. 2015, 2015: 624819.

Liu Y., Jin J., Qiao S., Lei S., Liao S., Ge Z.D., Li H., Wong G.T.C., Irwin M.G. and Xia Z., Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling, Clin Sci (Lond). 2015, 129(4): 331-44.

Low S.J., Wong S.C.S., Qiu Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W., An audit of changes in outcomes of acute pain service: evolution over the last 2 decades, Medicine. 2015, 94(40): e1673.

Luo C., Yuan D., Li X., Yao W., Luo G., Chi X., Li H., Irwin M.G., Xia Z. and Hei Z., Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexion 32, Anesthesiology. 2015, 122(1): 72-86.

Tian Y., Li H., Liu P., Xu J.M., Irwin M.G., Xia Z. and Tian G., Captopril pretreatment produces an additive cardioprotection to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans, Mediators Inflamm. 2015, 2015: 819232.

Tsui P.Y., Cheung C.W., Lee Y., Leung S.W.S. and Ng J.K.F., The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial, BMC Anesthesiol. 2015, 15: 80.

Wang D.L., Zhan L., Zhang J. and Xia Z., Nurses’ blame attributions towards different types of cancer: a cross-sectional study, Int J Nurs Stud. 2015, 52(10): 1600-6.

Wang X.M., Walitt B., Saligan L., Tiwari A.F., Cheung C.W. and Zhang Z.J., Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy, Cytokine. 2015, 72(1): 86-96.

Xia R., Xu J., Yin H., Wu H.Z., Xia Z., Zuo D., Xia Z.Y., Zhang L.P., LI H. and Xiao X., Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients, Mediators Inflamm. 2015, 2015: 238041.

Xia Z., Chen Y., Fan Q., Xue M.Z. and Liu K.X., Oxidative stress-mediated reperfusion injury 2014, Oxid Med Cell Longev. 2015, 2015: 689416.

Yao W., Irwin M.G., Wang T., Wang S., Zhang L. and Xia Z., Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1, Free Radic Biol Med. 84: 311-21.

Yu H.P., Chaudry I.H., Choudhry M.A., Hsing C.H., Liu F.C. and Xia Z., Inflammatory response to traumatic injury: clinical and animal researches in inflammation, Mediators Inflamm. 2015, 2015: 729637.

Zhou M., Bao Y., Li H., Pan Y., Shu L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M., Xu A., Jia W. and Hoo R.L.C., Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction., Clin Sci (Lond). 2015, 129(7): 547-59.



2014

Cheung C.W., Qiu Q., Choi S.W., Moore B.J., Goucke C.R. and Irwin M.G.,  Chronic opioid therapy for chronic non-cancer pain: a review and comparison of treatment guidelines, Pain Physician. 2014, 17(5): 401-14.

Cheung C.W., Qiu Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G.,  The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery, Anaesthesia. 2014, 69(11): 1214-21.

Cheung T.T., Poon R.T.P., Jenkins C.R., Chu S.K.F., Chok K.S.H., Chan A.C.Y., Tsang S.H.Y., Dai W.C., Yau T.C.C., Chan S.C., Fan S.T. and Lo C.M.,  Survival analysis of high-intensity focused ultrasound therapy vs. transarterial chemoembolization for unresectable hepatocellular carcinomas, Liver Int. 2014, 34(6): e136-43.

Feng L., Liu T.T., Ye D.W., Qiu Q., Xiang H.B. and Cheung C.W., Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: A virally mediated transsynaptic tracing study in transgenic mouse model, Epilepsy Behav. 2014, 31C: 114-6.

Greenland K.B. and Irwin M.G.,  Airway management - 'spinning silk from cocoons' (-Chinese idiom), Anaesthesia.  2014, 69(4): 296-00.

Hung V.K.L., Tai W.L., Qiu Q., Luo X., Wong K.L., Chung S.K. and Cheung C.W.,  Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Mol. Cell Nurosci. 2014, 60: 26-35.

Irwin M.G. and Gan T.J.,  Volume therapy with hydroxyethyl starches: are we throwing the anaesthesia baby out with the intensive care unit bathwater? Anesth. Analg. 2014, 119(3): 737-9.  

Li M.J., Wang L.Y., Xia Z., Wong M.P., Sham P.C. and Wang J.W.,  dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42: D910-6.

Luo X., Tai W.L., Sun L.T., Qiu Q., Xia Z., Chung S.K. and Cheung C.W.,  Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, PLoS One. 2014, 9(8): e104860.

Li B.L., Yuen V.M.Y., Song X.R., Ye J., Ni J., Huang J.X. and Irwin M.G.,  Intranasal dexmedetomidine following failed chloral hydrate sedation in children, Anaesthesia. 2014, 69(3): 240-4.

Li T., Li J., Li H., Xia Z., Shi X., Li X. and Liu Y.,  [Effects of hypertonic sodium chloride hydroxyethyl starch solution on cerebral vasospasm following subarachnoid hemorrhage and its mechanism]., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014, 26(8): 589-93.

Liu Y., Yang L., Tao K., Vizcaychipi M.P., Lloyd D.M., Sun X., Irwin M.G., Ma D. and Yu W.,  Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release, BMC Gastroenterol. 2014, 14(1): 12.

Lu Y., Wong G.T.C., Zhang Y., Hu J. and Dong C.,  Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine, Kaohsiung J Med Sci. 2014, 30(2): 68-72.

Mei W., Li M., Yu Y., Cheung C.W., Cao F., Nie B., Zhang Z., Wang P. and Tian Y.,  Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study, Eur J Pain. 2014, 18(2): 238-48.

Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G.,  Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period, Expert Opin Biol Ther. 2014, 14(1): 51-61.

Wen S.H., Ling Y.H., Liu W.F., Qiu Y.X., Li Y.S., Wu Y., Shen J.T., Xia Z. and Liu K.X.,  Role of 15-F2-isoprostane in intestinal injury induced by intestinal ischemia/reperfusion in rats, Free Radic Res. 2014, 48(8):  907-18.

Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G.,  Time to adequate oxygenation following ventilation using the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits, Paediatr Anaesth. 2014, 24(2): 208-13.

Wong K., Wu Y.R., Cheng K.S., Chan P., Cheung C.W., Lu D.Y., Su T.H., Liu Z.M. and Leung Y.M.,  Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes, Pharmacol Rep. 2014, 66(6): 1106-13.

Xia Z., Chen Y., Fan Q. and Xue M.,  Oxidative stress-mediated reperfusion injury: mechanism and therapies, Oxid Med Cell Longev. 2014, 2014: 373081.

Xu J., Li H., Irwin M.G., Xia Z.Y., MAO X., Lei S., Wong G.T.C., Hung V., Cheung C.W., Fang X., Clanachan A.S. and Xia Z.,  Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats, Crit Care Med. 2014, 42(8): e583-94.

Yao W., Luo G., Zhu G., Chi X., Zhang A., Xia Z. and Hei Z.,  Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model, Oxid Med Cell Longev. 2014, 2014: 258567.



2013

Chan W.W., Wong G.T.C. and Irwin M.G., Perioperative statin therapy, Expert Opin in Pharmacother. 2013, 14: 831-42. 

Cheung T.T., Fan S.T., Chan S.C., Chok K.S.H., Chu S.K.F., Jenkins C.R., Lo C.L.R., Fung J.Y.Y., Chan A.C.Y., Sharr W.W., Tsang S.H.Y., Dai W.C., Poon R.T.P. and Lo C.M., High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients, World J Gastroenterol. 2013, 19(20): 3083-9. 

Cheung T.T., Fan S.T., Chu S.K.F., Jenkins C.R., Chok K.S.H., Tsang S.H.Y., Dai W.C., Chan A.C.Y., Chan S.C., Yau T.C.C., Poon R.T.P. and Lo C.M., Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma, HPB (Oxford). 2013, 15(8): 567-73.

Cheung T.T., Poon R.T.P., Yuen W.K., Chok K.S.H., Jenkins C.R., Chan S.C., Fan S.T. and Lo C.M., Long-term survival analysis of pure laparoscopic versus open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a single-center experience, Ann Surg. 2013, 257(3):506-11. 

Chi X., Zhang A., Luo G., Xia H., Zhu G., Hei Z., Liu X., Wei J. and Xia Z., Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model, Pulm Pharmacol Ther. 2013, 26(3):380-7. 

Cho S.S., Rudloff I., Berger P.J., Irwin M.G., Nold M.F., Cheng W. and Nold-Perty C.A., Remifentanil ameliorates intestinal ischemia-reperfusion injury, BMC Gastroenterol. 2013, 13:69. 

Li H.B., Irwin M.G., Tao M., Li Y., Zhang L. and Xia Z., Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes, J Diabetes Metab. 2013, 4(3): 1000247. 

Li H.B., Liu Z., Wang J.W., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G., Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats, Cardiovasc Diabetol. 2013, 12(1):133. 

Li M.J., Wang Y., Xia Z., Sham P.C. and Wang J.W., GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications, Nucleic Acids Res. 2013, 41(WSI): W150-8. 

Li L., Zhang Q.G., Lai L.Y., Wen X.J., Zheng T., Cheung C.W., Zhou S.Q. and Xu S.Y., Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells. Oxid Med Cell Longev. 2013, 2013: 159864. 

Lei S., Li H., Xu J., Liu Y., Gao X., Wang J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z., Hyperglycemia-Induced protein kinase C beta2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling, Diabetes. 2013, 62(7): 2318-28. 

Leung K.M.M. and Irwin M.G., Perioperative cardioprotection, F1000Prime Rep. 2013, 5:7. 

Liao X.L., Hu X.X., Chang F.J., Yuan F.Y., Ci H.B., Wu J.Y., Xu Z., Wang Z.P., Zhang X., Xia Z. and Ou J.S., A simple modification results in greater success in the model of coronary artery ligation and myocardial ischemia in mice, J Cardiovasc Pharmacol. 2013, 61(5): 430-6.

Liu J., Hou J., Xia Z.Y., Zeng W., Wang X., Li R., Ke C., Xu J., Lei S. and Xia Z., Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes, Free Radic Res. 2013, 47(5): 386-93.

Mao X., Wang T., Liu Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z., N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats, PLoS ONE. 2013, 8(7): e68949.

Qin J., Li M.J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.W., ProteoMirExpress: inferring MicroRNA and Protein-centered regulatory networks from high-throughput proteomic and mRNA expression data, Mol Cell Proteomics. 2013, 12(11): 3379-87. 

Tai L.W., Hung V.K., Mei W., Qiu Q., Chung S. and Cheung C.W.*, Effects of repeated central administration of endothelin type A receptor antagonist on the development of neuropathic pain in rat, BioMed Res Int. 2013, 2013: 529871. 

Wang T., Yao S., Xia Z. and Irwin M.G., Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning, Front Med. 2013, 7(3): 301-5. 

Wang T., Mao X., Li H., Qiao S., Xu A., Wang J., Lei S., Liu Z., Ng K.F., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z., N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes, Free Radic Biol Med. 2013, 63: 291-03. 

Wang Y., Zhu Q., Luo C., Zhang A., Hei Z., Su G., Xia Z. and Irwin M.G., Dual effects of bilirubin on the proliferation of rat renal NRK52E cells and ITS association with gap junctions, Dose-Response. 2013, 11(2): 220-37.

Wong G.T.C. and Irwin M.G., Poisoning with illicit substances: toxicology for the anaesthetist, Anaesthesia. 2013, 68(S1): 117-24.

Wu H., Lei S., Yuan J., Liu X., Zhang D., Gu X., Zhang L. and Xia Z., Ischemic postconditioning downregulates Egr-1 expression and attenuates postischemic pulmonary inflammatory cytokine release and tissue injury in rats, J Surg Res. 2013, 181(2): 204-12.

Xu J., Lei S., Liu Y., Gao X., Irwin M.G., Xia Z.Y., Hei Z., Gan X., Wang T. and Xia Z., Antioxidant N-acetylcysteine attenuates the reduction of brg1 protein expression in the myocardium of type 1 diabetic rats, J Diabetes Res. 2013, 2013: 716219.

Ye D.W., Ding D.F., Liu T.T., Tian X.B., Liu C., Li R.C., Xiang H.B. and Cheung C.W., The optimal segment for spinal cord stimulation in intractable epilepsy: A virally mediated transsynaptic tracing study in spinally transected transgenic mice, Epilepsy Behav. 2013, 29(3): 599-01.



2012

Alaali H.H. and Irwin M.G., Anaesthesia for urologial surgery, Anaesth Intensive Care Med. 2012, 13 (7): 343-7. 

Cheung C.W., Choi W.W.S., Leung M.Y.Y., Lui F., Ng J.K.F., Ho A.M.H. and Irwin M.G.,  A double blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia, J Oral Maxillofac Surg. 2012, 70(1): 25-30. 

Cheung J.P.Y., Ng J.L.M., Chow W. and To M.K.T., Fat embolism syndrome in a child with dystonia musculorum deformans, BMJ Case Rep. 2012, doi: 10.1136/bcr.12.2011.5466. 

Cheung T.T., Chu F.S., Jenkins C.R., Tsang D.S., Chok K.S.H., Chan A.C.Y., Yau T.C.C., Chan S.C., Poon R.T.P., Lo C.M. and Fan S.T., Tolerance of high-intensity focused ultrasound ablation in patients with hepatocellular carcinoma, World J Surg. 2012, 36(10): 2420-7. 

Gao X., Xu Y., Xu B., Liu Y., Cai J., Liu H.M., Lei S., Zhong Y.Q., Irwin M.G. and Xia Z., Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes, Diabetes Metab Res Rev. 2012, 28(5): 409-17. 

Ho A.M.H., Dion P.W., Yeung J.H.H., Joynt G.M., Lee A., Ng C.S.H., Chang A., So F.L. and Cheung C.W., Simulation of survivorship bias in observational studies on plasma to red blood cells ratios in massive transfusion in trauma, Br J Surg. 2012, 99(S1): 132-9. 

Ho A.M.H., Dion P.W., Yeung J.H.H., Holcomb J.B., Critchley L.A.H., Ng C.S.H., Karmakar M.K., Cheung C.W. and Rainer T.H., Prevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusion, Anesthesiology. 2012, 116(3): 716-28. 

Ho A.M., Ricci C.J., Ng C.S., Critchley L.A., Ho A.K., Karmakar M.K., Cheung C.W. and Ng S.K., The medial-transverse approach for internal jugular vein cannulation: an example of lateral thinking, J Emerg Med. 2012, 42(2): 174-7. 

Huang P., Liu D., Gan X., Zhang R., Gao W., Xia Z. and Hei Z., Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats, Injury. 2012, 43(8): 1250-6. 

Hung K.L., Chan M.M., Chen A.Y.S., Tai L.W., Chung S.K. and Cheung C.W., Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection, Life Sci. 2012, 91(13-14): 618-22. 

Irwin M.G. and Wong S.S.C., Anaesthesia and minimally invasive surgery, Anaesth Int Care Med. 2012, 13(2): 48-51. 

Irwin M.G. and Wong S.S.C., Anaesthesia for fractured neck of femur, Anaesth Int Care Med. 2012, 13(3): 94-8. 

Lei S., Liu Y., Liu H., Yu H., Wang H. and Xia Z., Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats, Yonsei Med J. 2012, 53(2): 294-303. 

Li T., Wu W., You Z., Zhou R., Li Q., Zhu D., Li H., Xiang X., Irwin M.G. and Xia Z., Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass, Eur J Pharmacol. 2012, 677(1-3): 138-46.

 Liu K.X. and Xia Z., Potential synergy of antioxidant N-acetylcysteine and insulin in restoring sevoflurane postconditioning cardioprotection in diabetes, Anesthesiology. 2012, 116(2):488-9. 

Liu Y, Lei S, Gao X, Mao X, Wang T, Wong GT, Vanhoutte PM, Irwin MG, Xia Z. PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes, Clin Sci (Lond). 2012, 122(4):161-73. 

Lu D.Y., Chang C.S., Yeh W.L., Tang C.H., Cheung C.W., Leung Y.M., Liu J.F. and Wong K.L., The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways, Phytomedicine. 2012, 19(12): 1093-100. 

Ng F.Y., Ng J.K.F., Chiu P.K.Y., Yan C.H. and Chan C.W., Multimodal periarticular injection vs continuous femoral nerve block after total knee arthroplasty: a prospective, crossover, randomized clinical trial, J Arthroplasty. 2012, 27(6): 1234-8. 

Poon T.C.J., Cheung C.W., Fan J.K.M., Lo O.S.H. and Law W.L., Single-incision versus conventional laparoscopic colectomy for colonic neosplasm: arandomized,controlled trial, Surg Endosc. 2012, 26(10): 2729-34. 

Sharma A., Lawmin J. and Irwin M.G., Anaesthesia for spinal surgery, Anaesth Int Care Med. 2012, 13(3): 99-101. 

Wang Y., Wong G.T.C., Man K., Irwin M.G.,  Pretreatment with intrathecal or intravenous morphine attenuates hepatic ischaemia-reperfusion injury in normal and cirrhotic rat liver, Br J Anaesth. 2012, 109(4): 529-39. 

Wong G.T.C. and Irwin M.G., EVAR fever: minimally invasive, maximally inclusive? Anaesthesia. 2012, 67(4): 351-4. 

Wong G.T.C., Lu Y., Mei B., Xia Z. and Irwin M.G., Cardioprotection from remote preconditioning involves spinal opioid receptor activation, Life Sci. 2012, 91(17-18): 860-5. 

Wong G.T.C., Lu Y, Xia Z, Irwin M.G.,  Intrathecal morphine remotely preconditions the heart via a neural pathway, J Cardiovasc Pharmacol. 2012, 60(2): 172-8. 

Wong S. and Irwin M.G., Procedures under tourniquet, Anaesth Int Care Med. 2012, 13(3): 85-8. 

Wylie S.J., Wong G.T.C., Chan Y.C. and Irwin M.G., Endovascular aneurysm repair: a perioperative perspective, Acta Anaesthesiol Scand. 2012, 56(8): 941-9. 

Yuen V.M.Y., Hui T.W.C., Irwin M.G., Yao T.J., Chan L., Wong G.L., Shahnaz Hasan M. and Shariffuddin I.I., A randomised comparison of two intranasal dexmedetomidine doses for premedication in children, Anaesthesia. 2012, 67(11): 1210-6. 

Zhang Y.M., Wang C.Y., Zheng F.C., Gao F.F., Chen Y.C., Huang Z.Q., Xia Z., Irwin M.G., Li W.Q., Liu X.P., Zheng Y.S., Xu H. and Shi G.G., Effects of N-n-butyl haloperidol iodide on the rat myocardial sarcoplasmic reticulum Ca(2+)-ATPase during ischemia/reperfusion, Biochem Biophys Res Commun. 2012, 425(2): 426-30.



2011

Chan B.K.B., Tam L.K., Chung Y.F., Wat C.Y., Tsui S.L. and Cheung C.W.,  Opioids in Chronic non-cancer pain, Expert Opin Pharmacother. 2011, 12(5): 705-20. 

Chan S.C., Lo C.M., Ng K.K.C., Ng I.O.L., Yong B.H. and Fan S.T.,  Portal inflow and pressure changes in right liver living donor liver transplantation including the middle hepatic vein, Liver Transpl. 2011, 17(2): 115-21.
 
Cheung C.W., Ng J.K.F., Liu J., Yuen V.M.Y., Ho M.H.A. and Irwin M.G.,  Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia, Br J Anaesth. 2011, 107(3):430-7. 
 
Cheung C.W., Ng J.K.F., Choi W.W.S., Chiu W.K., Ying C.L.A. and Irwin M.G.,  Evaluation of the analgesic efficacy of local dexmedetomidine application, Clin J Pain. 2011, 27(5): 377-82. 
 
Chou C.W., Wong G.T.C., Lim G., McCabe M.F., Wang S., Irwin M.G. and Mao J., Peripheral nerve injury alters the expression of NF-κB in the rat's hippocampus, Brain Res. 2011, 1378: 66-71. 
 
Chou C.W., Wong G.T.C., Lim G., Wang S., Irwin M.G. and Mao J.,  Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury, J Pain. 2011, 12(1): 13-21. 
 
Fan Q., Yang X.C., Liu Y., Wang L.F., Liu S.H., Ge Y.G., Chen M.L., Wang W., Zhang L.K., Irwin M.G. and Xia Z.,  Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans, Clin Sci (Lond). 2011, 120(6): 251-61. 
 
Huang S.M., Cheung C.W., Chang C.S., Tang C.H., Liu J.F., Lin Y.H., Chen J.H., Ko S.H., Wong K. and Lu D.Y.,  Phloroglucional derivative MCPP induces cell apoptosis in human colon cancer, J Cell Biochem. 2011, 112(2): 643-52. 
 
Huang Z., Zhong X.W., Irwin M.G., Ji S., Liu Y., Xia Z.Y.,  Finegan B.A. and Xia Z., Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients, Clin Sci (Lond). 2011, 121(2): 57-69. 
 
Hung I.F.N., To K.K.W., Lee C.K., Lee K.L., Chan K., Yan W.W., Liu R., Watt C.L., Chan W.M., Lai K.Y., Koo C.K., Buckley T., Chow F.L., Wong K.K., Chan H.S., Ching C.K., 
Tang B.S.F., Lau C.Y., Li W.S., Liu S.H., Chan K.H., Lin C.K. and Yuen K.Y.,  Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection, Clin Infect Dis. 2011, 52(4): 447-56. 
 
Liu H.M., Liu K.X., Cheng M.H., Liu Y., Lei S., Irwin M.G. and Xia Z.,  Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts, J Surg Res. 2011, 168(1): 18-26.
 
Lu Y., Wong G.T.C., Xia Z. and Irwin M.G.,  Interaction between spinal opioid and adenosine receptors in the remote cardiac preconditioning effect of intrathecal morphine, J Cardiothorac Vasc Anesth. 2011, 25(3):444-8. 
 
Lui F. and Ng J.K.F.,  Adjuvant analgesics in acute pain, Expert Opin Pharmacother. 2011, 12(3): 363-85. 
 
Ng J.K.F., Cheung C.W. and Lee Y.,  Low dose desmopressin improves hypothermia induced impairment of primary haemostasis in healthy volunteers, Anaesthesia. 2011, 66(11):999-1005. 
 
Tse E.Y.W., Cheung W.Y., Ng J.K.F. and Luk K.D.K.,  Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery, J Bone Joint Surg Am. 2011, 93(13): 1268-77. 
 
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Xu A., Lam K.S.L., Irwin M.G. and Xia Z.,  N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats, PLoS One. 2011, 6(8):e23967.  
 
Wei L., Le X.C., Xia Z., Han Y. and Rong J., Pharmacological induction of leukotriene B4 12-hydroxydehydrogenase in human neutrophils and its potential in the treatment of myocardial injury, Journal of Heart Disease, Cardiology Online. 2011, 8: 66. 
 
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R.,  Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain, J Mol Cell Cardiol. 2011, 51(6): 966-73. 
 
Xia Z. and Vanhoutte P.M.G.R.,  Nitric oxide and protection against cardiac ischemia, Curr Pharm Des. 2011, 17(18): 1774-82. 
 
Xu B., Gao X., Xu J., Lei S., Xia Z.Y., Xu Y. and Xia Z.,  Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1, J Surg Res. 2011, 166(2): e157-64. 
 
Yang L.Q., Tao K.M., Liu Y.T., Cheung C.W., Wong G.T.C., Lv H., Song J.G., Wu F.X. and Yu W.F.,  Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression, Anesthesiology. 2011, 114(5): 1036-47. 
 
Zhang Y., Lu Y., Mei B., Zhou Y.M., Chen Z.W. and Wong T.M.,  Intracerebroventricular administration of morphone confers remote cardioprotecion - role of opioid receptors and calmodulin, Eur J Pharmacol. 2011, 656(1-3):74-80. 
 
Zhu X.H., Yuan H.J., Wu Y.N., Kang Y., Jiao J.J., Gao W.Z., Liu Y.X., Lou J.S. and Xia Z.,  Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats, Free Radic Res. 2011, 45(2): 201-10.  


2010

Chan S.C., Lo C.M., Yong B.H., Tsui W.J.C., Ng K.K.C. and Fan S.T., Paired donor interchange to avoid ABO-incompatible living donor liver transplantation, Liver Transpl. 2010, 16(4): 478-81. 

 
Cheng T.H., Leung Y.M., Cheung C.W., Chen C.H., Chen Y.L. and Wong K.L., Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts, Anesthesiology. 2010, 112(1): 108-18. 
 
Chiang J.C.S., Irwin M.G., Hussain A., Tang Y.K. and Hiong Y.T., Anaesthesia for emergency caesarean section in a patient with large anterior mediastinal tumour presenting as intrathoracic airway compression and superior vena cava obstruction, Case Report Med. 2010, 2010:708481. 
 
Greenland K.B., Edwards M.J., Hutton N.J., Challis V.J., Irwin M.G. and Sleigh J.W.,  Changes in airway configuration with different head and neck positions using magnetic resonance imaging of normal airways: a new concept with possible clinical applications, Br J Anaesth. 2010, 105(5): 683-90. 
 
Guo Y., Wu X.Q., Zhang C., Liao Z.X., Wu Y., Xia Z. and Wang H.,  Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices, Clin Exp Pharmacol Physiol. 2010, 37(12): 1107-13. 
 
Ho A.M.H., Dion P.W., Yeung Y.H.H., Ng C.S.H., Karmakar M.K., Crtichley L.A.H., Rainer T.R., Cheung C.W. and Tay B.A.,  Fresh-frozen plasma transfusion strategy in trauma with massive and ongoing bleeding. Common (sense) and sensibility, Resuscitation. 2010, 81(9): 1079-81. 
 
Jiang L., Wong G.T.C., Lu Y., Xia Z. and Irwin M.G.,  Remote pharmacological post-conditioning by intrathecal morphine: cardiac protection from spinal opioid receptor activation, Acta Anaesthesiol Scand. 2010, 54(9): 1097-04. 
 
Lau T.W., Leung F.K.L., Siu D.C.W., Wong G.T.C. and Luk K.D.K.,  Geriatric hip fracture clinical pathway: the Hong Kong experience, Osteoporosis Int. 2010, 21(S4): S627-36. 
 
Li Y.S., Wang Z.X., Li C., Xu M., Li Y., Huang W.Q., Xia Z. and Liu K.X.,  Proteomics of ischemia/reperfusion injury in rat intestine with and without ischemic postconditioning, J Surg Res. 2010, 164(1):e173-80. 
 
Liang S. and Irwin M.G., Review of anesthesia for middle ear surgery, Anesthesiol Clin. 2010, 28(3): 519-28. 
 
Liu K.X., Li C., Li Y.S., Yuan B.L., Xu M., Xia Z. and Huang W.Q.,  Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase, Proteomics. 2010, 10(24):4463-75. 
 
Lu D.Y., Leung Y.M., Cheung C.W., Chen Y.R. and Wong K.,  Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells, Biochem Pharm. 2010, 80(8):1201-9. 
 
Chan A.K., Cheung C.W. and Chong Y.K.,  Alpha-2 agonists in acute pain management, Expert Opin Pharmacother. 2010, 11(17):2849-68. 
 
Poon J.T.C., Cheng S.W.K., Wong S.J. and Ting A.C.W.,  Prevalence of abdominal aortic aneurysm in Chinese patients with severe coronary artery disease, ANZ J Surg. 2010, 80(9):630-3. 
 
Siu D.C.W., Sun N.C.H., Lau T.W., Yiu K.H., Leung F.K.L. and Tse H.F.,  Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective. Osteoporos Int. 2010, 21(S4):S587-91.  
 
Tan G. and Irwin M.G.,  Recent advances in using propofol by non-anesthesiologists, F1000 Med Rep. 2010, 2:79. 
 
Wang M., Peng J., Wang R., Zhao L. and Xia Z.,  TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits, J Surg Res. 2010 Sept In press. 
 
Wong E.S.W., Man R.Y.K., Vanhoutte P.M. and Ng K.F.J.,  Dexmedetomidine induces both relaxations and contractions, via different α2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat, J Pharmacol Exp Ther.  2010, 335(3): 659-64
 
Wong G.T.C. and Irwin M.G.,  Pretreatment time with norbinaltorphimine [Letter], Anesth Analg. 2010, 110(4): 1243-4. 
 
Wong G.T.C. and Sun N.C.H.,  Providing perioperative care for patients with hip fractures, Osteoporos Int. 2010, 21(S4): S547-53. 
 
Wong G.T.C., Jiang L.L. and Irwin M.G.,  Activation of central opioid receptors induces cardioprotection against ischemia-reperfusion injury, Anesth Analg. 2010, 111(1): 24-8. 
 
Wong G.T.C., Li R., Jiang L. and Irwin M.G.,  Remifentanil post-conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation, Acta Anaesthesiol Scand. 2010, 54(4): 510-8.
 
Wong G.T.C., Huang Z., Ji S. and Irwin M.G.,  Remifentanil reduces the release of biochemical markers of myocardial damage after coronary artery bypass surgery: a randomized trial, J Cardiothorac Vasc Anesth. 2010, 24(5): 790-6. 
 
Xia Z., Luo T., Liu H., Wang F., Xia Z.Y., Irwin M.G. and Vanhoutte P.M.G.R.,  L-arginine enchances nitrative stress and exacerbates tumor necrosis factor-α toxicity to human endothelial cells in culture: prevention by propofol, J Cardiovasc Pharmacol. 2010, 55(4): 358-67. 
 
Yang L.Q., Tao K.M., Cheung C.W., Liu Y.T., Tao Y., Wu F.X. and Yu W.F.,  The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients, Anaesthesia. 2010, 65(11): 1094-00.  
 
Yang L.Q., Song J.C., Irwin M.G., Song J.G., Sun Y.M. and Yu W.F.,  A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice, Acta Aaesthesiol Scand. 2010, 54(7): 871-7. 
 
Yuen V.M.Y., Hui T.W.C., Irwin M.G., Yao T.J., Wong G.L.S. and Yuen M.K.,  Optimal timing for the administration of intranasal dexmedetomidine for premedication in children, Anaesthesia. 2010, 65(9):922-9. 
 
Zhang J.F., Yang J.P., Wang G.H., Xia Z., Duan S.Z. and Wu Y.,  Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion, Diabetes Metab Res Rev. 2010, 26(1): 59-70. 


2009


Chan A.C., Fan S.T., Lo C.M., Liu C.L., Chan S.C., Ng K.K., Yong B.H., Chiu A. and Lam B.K.,  Liver transplantation for acute-on-chronic liver failure, Hepatol Int. 2009, 3(4): 571-81. 
 
Cheung C.W., Ying C.L., Lee L.H., Tsang S.F., Tsui S.L. and Irwin M.G.,  An audit of postoperative intravenous patient-controlled analgesia with morphine: evolution over the last decade, Eur J Pain. 2009, 13(5): 464-71. 
 
Choi W.S., Irwin M.G. and Samman N.,  The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial, J Oral Maxillofac Surg. 2009, 67(1): 125-33. 
 
Chung P.H.Y., Wong K.K.Y., Tam P.K.H., Chan K.L., Ng K.K.C., Chan S.C., Hui T.W.C., Yong B.H., Fan S.T. and Lo C.M.,  Split graft liver transplant for paediatric patients in Hong Kong, HK J Paediatr (new series). 2009, 14(3): 181-5. 
 
Irwin M.G., Trinh T.P. and Yao C.L.,  Occupational exposure to anaesthetic gases: a role for TIVA, Expert Opin Drug Saf. 2009, 8(4): 473-83. 
 
Kong V.K.F. and Irwin M.G.,  Adjuvant analgesics in neuropathic pain, Eur J Anaesthesiol. 2009, 26(2): 96-100. 
 
Li R., Wong G.T.C., Wong T.M., Zhang Y., Xia Z. and Irwin M.G.,  Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa and mu opioid receptors in rats, Anesth Analg. 2009, 108(1): 23-9. 
 
Liu K.X., Li Y.S., Huang W.Q., Chen S.Q., Wang Z.X., Liu J.X. and Xia Z.,  Immediate postconditioning during reperfusion attenuates intestinal injury, Intensive Care Med. 2009, 35(5): 933-42. 
 
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y.,  The value of a single preoperative PFA-100® measurement in assessing the risk of bleeding in patients taking cyclooxygenase inhibitors and undergoing total knee replacement, Br J Anaesth. 2009, 102(6): 779-84. 
 
Poon C.C. and Irwin M.G.,  Anaesthesia for deep brain stimulation and in patients with implanted neurostimulator devices, Br J Anaesth. 2009, 103(2): 152-65. 
 
Tam L.K. and Ng J.K.F.,  The role of desmopressin in a patient with severe coagulopathy aggravated by mild therapeutic hypothermia [letter], Resuscitation. 2009, 80(10): 1216-7. 
 
Tam M.K., Irwin M.G., Tse M.L., Lui Y.W., Law K.I. and Ng P.W.,  Prolonged myoclonus after a single bolus dose of propofol, Anaesthesia. 2009, 64(11): 1254-7. 
 
Tsai G.Y., Cui J.Z., Syed H., Xia Z., Ozerdem U., McNeill J.H. and Matsubara J.A.,  Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats, Clin Experiment Ophthalmol. 2009, 37(2): 223-31. 
 
Wang F., Liu H.M., Irwin M.G., Xia Z.Y., Huang Z., Ouyang J. and Xia Z.,  Role of protein kinase C β2 activation in TNF-α-induced human vascular endothelial cell apoptosis, Can J Physiol Pharmacol. 2009, 87(3): 221-9. 
 
Xia Z. and Irwin M.G.,  Esmolol may abolish volatile anesthetic-induced postconditioning by scavenging reactive oxygen species, Anesthesiology. 2009, 111(4): 924-5. 
 
Zhang Y., Irwin M.G., Li R., Chen Z.W. and Wong T.M.,  Effects of remifentanil on intracellular Ca2+ and its transients induced by electrical stimulation and caffeine in rat ventricuar myocytes, Chinese Med J. 2009, 122(12): 1439-43. 


2008

Chan Y.C., Cheng S.W.K. and Irwin M.G., Perioperative use of statins in noncardiac surgery, Vasc Health Risk Manag. 2008, 4(1): 75-81.

Cheung C.W., Irwin M.G., Chiu W.K. and Ying C.L.A., A study to assess the value of bispectral analysis in intravenous sedation with midazolam during third molar surgery under local anaesthesia, Anaesthesia. 2008, 63(12): 1302-8.

Chia A.C., Irwin M.G., Lee P.W., Lee T.H. and Man S.F., Comparison of stress in anaesthetic trainees between Hong Kong and Victoria,  Anaesth Intensive Care. 2008, 36(6): 855-62.

Fung N.Y., Hu Y., Irwin M.G., Chow B.E. and Yuen V.M.Y.,  Comparison between sevoflurane/remifentanil and propofol/remifentanil anaesthesia in providing conditions for somatosensory evoked potential monitoring during scoliosis corrective surgery, Anaesth Intensive Care. 2008, 36(3): 779-85.

Greenland K.B., Eley V., Edwards M.J., Allen P. and Irwin M.G.,  The origins of sniffing position and the Three Axes Alignment Theory for direct laryngoscopy, Anaesth Intensive Care. 2008, 36(S1): 23-7.

Ho E.Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M. and Ng J.K.F.,  Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, FASEB Journal. 2008, 22: 914.10.

Lee L.H.Y., Irwin M.G., Yao T.J., Yuen M.K. and Cheung C.W.,  Timing of intraoperative parecoxib analgesia in colorectal surgery, Acute Pain. 2008, 10(3-4): 123-30.

Liu K.X., Huang W.Q., Li Y.S., Irwin M.G. and Xia Z.,  Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats, Anesth Analg. 2008, 107(6): 1884-91.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.,  C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary artery, FASEB J. 2008, 22: 914.3.

Ng J.K.F., Tsang S.F., Leung S.W.S., Tang W.M. and Chiu P.K.Y.,  Coagulation, blood loss and platelet activation during isoflurane or sevolfurane anaesthesia, Anesthesiology. 2008, 109: A1619.

Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y.,  Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac., J Arthroplasty. 2008, 23(3): 424-30.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.,  Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins, Acta Pharmacol Sin. 2008, 29(12): 1419-24.

Ng W.W.H., Keung W.W.Y., Xu Y.C., Ng J.K.F., Leung G.P.H., Vanhoutte P.M., Choy P.C. and Man R.Y.K., Genistein potentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311(1-2): 37-44.

Nie R., Zhong X. and Xia Z.,  Antioxidant intervention before and during myocardial ischemia may exacerbate post-ischemic myocardial dysfunction: relationship with endothelin-1 production, Med Hypotheses. 2008, 70(1): 194-5.

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transpl. 2008, 14(7): 1038-43.

Xia Z.,  Role of hydrogen peroxide in propofol restoration of microvacular function impaired by high glucose, Anesthesiology. 2008, 109(5): 930.

Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G.,  Anaesthesia for high intensity focused ultrasound (HIFU) therapy, Anaesthesia. 2008, 63(8): 865-72.

Ying C.L.A., Tsang S.F. and Ng J.K.F.,  The potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100?, Resuscitation. 2008, 76(1): 129-33.

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K.,  A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial, Anesth Analg. 2008, 106(6): 1715-21.



Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C., Ng J.K.F. and Irwin M.G.,  A comparison of dexmedetomidine and midazolam for sedation in third molar surgery, Anaesthesia. 2007, 62(11): 1132-8.

DiemunschP., Gan T.J., Philip B.K., Girao M.J., Eberhart L., Irwin M.G., Pueyo J. and Lawson F.C.,  Single-dose aprepitant versus ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery, Br J Anaesth. 2007, 99(2): 202-11.

Greenland K.B., Liu G., Tan H., Edwards M. and Irwin M.G., Comparison of the Levitan FPS ScopeTM and the single-use bougie for simulated difficult intubation in anaesthetised patients, Anaesthesia. 2007, 62(5): 509-15.

Greenland K.B., Tsui D., Goodyear P. and Irwin M.G., Personal protection equipment for biological hazards: does it affect tracheal intubation performance?  Resuscitation. 2007, 74(1): 119-26.

GuoC.X.X., Irwin M.G., Cheung K.M.C. and Chan D., An effective dose of Valdecoxib in experimental mouse models of pain, Methods Find Exp Clin Pharmacol. 2007, 29(6): 383-8.

Kong V.K.F. and Irwin M.G., Gabapentin: a multimodal perioperative drug?  Br J Anaesth. 2007, 99(6): 775-86.

Kong V.K.F., Yuen M.K. and Irwin M.G., Perioperative ultrasonography: ultrasound and vascular cannulation, CPD Anaesthesia. 2007, 9(1): 3-9.

Yu C.K., Li Y.H., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat, Br J Anaesth. 2007, 99(5): 632-8.

NieR., Xia R., Zhong X. and Xia Z., Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat, Can J Physiol Pharmacol. 2007, 85(10):1012-9.

Wong G.T.C., Jenkins C.R., Yao T.J. and Irwin M.G., A trend toward improved learning of cardiovascular pathophysiology in medical students from using a human patient simulator: results of a pilot study, Advan in Physiol Edu. 2007, 31(4): 372.

Wong G.T.C. and Irwin M.G., Contrast-induced nephropathy, Br J Anaesth. 2007, 99(4): 474-83.

Wong G.T.C., Yuen V.M.Y., Chow B.F.M. and Irwin M.G., Persistent pain in patients following scoliosis surgery, Eur Spine J. 2007, 16(10): 1551-6.

Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double-blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anesth Analg. 2007, 105(2): 374-80.



Caves N.D. and Irwin M.G., Attitudes to basic life support among medical students following the 2003 SARS outbreak in Hong Kong, Resuscitation. 2006, 68(1): 93-100.

CheungR.W., Irwin M.G., Law B.C.W. and Chan C.K., A clinical comparison of the FlexibladeTM and Macintosh laryngoscopes for laryngeal exposure in anesthetized adults, Anesth Analg.  2006, 102(2): 626-30.

Fielding R. and Irwin M.G., The knowledge and perceptions of nurses and interns regarding acute pain and postoperative pain control (Research dissemination report – nursing studies), Hong Kong Med J. 2006, 12(2-S1): 31-4.

Greenland K.B., Ha I.D. and Irwin M.G., Comparison of the Berman intubating airway and the Williams airway intubator for fibreoptic orotracheal intubation in anaesthetised patients, Anaesthesia. 2006, 61(7): 678-84.

Irwin M.G., "NSAIDs - can't live with them… can't live without them", European Society of Anaesthesiology Newsletter. 2006, 26(Spring):10-11.

KanA.S.Y., Caves N.D., Wong S.Y.W., Ng E.H.Y. and Ho P.C.,  A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination, Hum Reprod. 2006, 21(10): 2606-11.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Ann Surg. 2006, 243(3): 404-10.

Ng J.K.F., Yuen T.S.T. and Ng V.M.W., A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia, J Clin Anesth. 2006, 18(3): 205-10.

Wong A.Y.C., O'Regan A.M. and Irwin M.G., Total intravenous anaesthesia with propofol and remifentanil for elective neurosurgical procedures: an audit of early postoperative complications, Eur J Anaethesiol. 2006, 23(7): 586-90.

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anaesthesia: a double-blinded randomized controlled trial, Anesth Analg. 2006, 106(6): 1715-21.

 



Guo X., Irwin M.G., Chan D., Tipoe G.L. and Cheung K.M.C., Differential functions of cyclooxygenase 1 and 2 in bone repair, European Cells and Materials. 2005, 10(S3): 56.

Irwin M.G., Preemptive analgesia (Letter). Spine J. 2005, 5(2): 229.

Kwok Y., Ng J.K.F., Li C.F., Lam C.C.K. and Man R.Y.K., A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma Lucidum (Ling-Zhi) in healthy volunteers, Anaesth Analg. 2005, 101(2): 423-6.

Lee L.H.Y., Irwin M.G. and Lui S.K., Intraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxide, Anesthesiology.  2005, 102(2): 398-02.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Yong B.H. and Wong J., Safety of donor right hepatectomy without abdominal drainage: a prospective evaluation in 100 consecutive liver donors, Liver Transpl. 2005, 11(3): 314-9.

Ng J.K.F., Vanhoutte P.M.G.R. and Man R.Y.K., The role of pertussis toxin sensitive pathways in EDHF mediated relaxation in porcine coronary arteries, J Vas Res.  2005, 42(S1): S2010.

Sun N.C.H., Wong A.Y.C. and Irwin M.G., A comparison of pain on intravenous injection between two preparations of propofol, Anesth Analg. 2005, 101 (3): 675-8.

Wong A.Y.C. and Irwin M.G., Large venous air embolism in the sitting position despite monitoring with transoesophageal echocardiography, Anaesthesia. 2005, 60 (8): 811-3.

Yuen T.S.T. and Irwin M.G., The "fifth vital sign", Hong Kong Med J. 2005, 11 (3): 145-6.

Yuen V.M.Y., Chow B.F.M. and Irwin M.G.,  Severe hypotension and hepatic dysfunction in a patient undergoing scoliosis surgery in the prone position, Anaesth Intensive Care. 2005, 33 (3): 393-9.

Zhang Y., Chen Z.W., Irwin M.G. and Wong T.M., Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats, Acta Pharmacologica Sinica. 2005, 26(5): 546-50.

Zhang Y., Irwin M.G., Wong T.M., Chen M. and Cao C., Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors, Anesthesiology. 2005, 102(2): 371-8.