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Current Research Projects
Our academic staffs carry out a variety of clinical and laboratory research studies covering the areas of acute and chronic pain management, anaesthetic therapies development, and diabetic cardiomyopathy protection.

Our pain laboratory research studies the mechanisms of pain, specifically hyperalgesia and chronic pain development, and the possible therapeutics for pain management. We use a variety of pain models, including inflammatory pain, post-stroke pain, neuropathic pain in vivo in transgenic mice and SD rats. We also study the mechanisms of several drugs with the aid of some astrocytic cell culture model.

Our cardiovascular research focuses in the protection of myocardial ischemia-reerfusion injury (IRI) of diabetic hearts, specifically in diabetic cardiomyopathy. In vivo animal models, as well as in vitro cell culture and isolated cardiovascular models are used to study respectively the reactive oxygen species (ROS) in diabetic cardiomyopathic conditions, possible therapeutic antioxidant treatments for myocardial IRI, and the anaesthetic pre- and post-conditioning in diabetic cardiomyopathy.

Some Current Research Projects
  • A bioinformatics framework to identify cooperation of transcription factors in regulating cancer progression
  • An evaluation of an innovative peer supported model for clinical skills learning - structuring roles in peer supported teaching
  • Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial
  • Central CXCL12/CXCR4 axis contributes to the induction of peripheral neuropathic pains
  • Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging
  • Determining the role of histone deacetylase 2 (HDAC2) in the pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN)
  • Effects of intraoperative total intravenous anaesthesia with propofol versus inhalational anaesthesia on postoperative pain after hepatectomy: a randomized controlled trial
  • Effects of ketamine on the CGRP-CRLR ligand-receptor complex and pain signaling
  • Forced resistant exercise preconditioning reduces postoperative cognitive dysfunction in mice
  • Increased FoxO1 activation renders the diabetic heart susceptibility to ischemia/reperfusion injury
  • Intrathecal administration of RhoA, ROCK and ERK inhibitors reduces thermal and inflammatory hyperalgesia in DLC2-/- (knockout) miceof STAT-3 activation
  • PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association
  • PKC-β2 through downregulating Caveolin-3 increases diabetic heart vulnerability to ischemia-reperfusion injury
  • Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response
  • Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice
  • Repressor activator protein 1 protects against mitochondrial function and ischemia/reperfusion injury in aging heart via PGC1a signaling activation
  • Restoration of volatile anesthetic postconditioning cardioprotection in diabetes - role of Brg1 mediated Nrf2/STAT3 activation
  • Role of Brg1 in sevoflurane postconditioning cardioprotection in normal and diabetic rodents and its interplay with STAT3
  • Role of Cardiac STAT5A in repeated non-invasive limb ischemic preconditioning-induced cardioprotection in diabetes and its interplay with STAT3
  • Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus
  • Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts
  • The evaluation of insulin resistance as a precipitating factor for postoperative cognitive dysfunction
  • The role of Deleted in Liver Cancer 2 (DLC2) with RhoGAP activity in a mice model of chronic regional pain syndrome type 1
  • The role of surgery induced type 1 interferon on blood brain barrier dysfunction and postoperative cognitive dysfunction
  • Laboratory and Clinical Research Institute for Pain