Aitkenhead AR, Irwin MG. Deaths associated with anaesthesia - 65 years on. Anaesthesia 2021; 76(2): 277-80. 

Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, Wang S, Xu A, Xia Z. Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling. Theranostics 2021; 11: 4710-27.

Chan E, Botelho MG, Wong GTC. A flipped classroom, same-level peer-assisted learning approach to clinical skill teaching for medical students. PLoS One 2021; 16(10): e0258926.

Chan WKV, Chan PK, Fu H, Chan CW, Yan CH, Chiu KY. Combination effect of high-dose preoperative and periarticular steroid injection in total knee arthroplasty. A randomized controlled study. J Arthroplasty 2021; 36(1): 130-4.e2.

Chen XK, Yi ZN, Wong GT, Hasan KMM, Kwan JSK, Ma ACH, Chang RCC. Is exercise a senolytic medicine? a systematic review. Aging Cell 2021; 20(1): e13294.

Curtin J, Wong GTC, Wang W, Thomson P, Lam AK, Choi SW. A comparison of two methods for the detection of circulating tumour cells in patients with oral cavity cancer. J Oral Pathol Med 2021; [Online ahead of print].

Deng L, Lei S, Wang X, Jiang F, Lubarsky DA, Zhang L, Liu D, Han C, Zhou D, Wang Z, Sun X, Zhang Y, Cheung CW, Wang S, Xia Z, Applegate RL, Tang J, Mai Z, Liu H, Xia Z. Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysis. Aging (Albany NY) 2021; 13(12): 15801-14.

Green SM, Irwin MG, Manson KP. Procedural sedation: providing the missing definition. Anaesthesia 2021; 76(5): 598-601.

Gu P, Fan T, Wong SSC, Pan Z, Tai WL Chung SK, Cheung CW. Central Endothelin-1 confers analgesia by triggering spinal neuronal histone deacetylase 5 (HDAC5) nuclear exclusion in peripheral neuropathic pain in mice. J Pain 2021; 22(4): 454-71.

Han X, Lu Y, Fang Q, Fang P, Wong GTC, Liu X. Effects of epidural anesthesia on quality of life in elderly patients undergoing esophagectomy. Semin Thorac Cardiovasc Surg 2021; 33(1): 276-85.

Kimura LF, Novaes LS, Picolo G, Munhoz CD, Cheung CW, Camarini R. How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders. Br J Pharmacol 2021; [Online ahead of print].

Lam DMH, Wang C, Lee AKH, Chung YF, Lau TW, Fang C, Leung F, Chan CWT. Multi-component care bundle in geriatric fracture hip for reducing post-operative delirium. Geriatr Orthop Surg Rehabil 2021; 12: 21514593211004530.

Lam SW, Irwin MG. Pre‐oxygenation for rapid sequence induction: is high‐flow nasal oxygenation worth the hassle? Anaesthesia 2021; 76(9): 1159-62.

Li S, Li X, Xie X, Wei X, Yu C, Cheung CW, Xia Z, Tian G. N-Acetylcysteine attenuates hyperalgesia in rats with diabetic neuropathic pain: role of oxidative stress and inflammatory mediators and CXCR4. J Diabetes Res 2021; 2021: 8862910.

Liu JA, Yu J, Cheung CW. Immune actions on the peripheral nervous system in pain. Int J Mol Sci 2021; 22(3): 1448.

Liu X, Hu J, Hu X, Li R, Li Y, Wong GTC, Zhang Y, study group. Preemptive intravenous nalbuphine for the treatment of post-operative visceral pain: a multicenter, double-blind, placebo-controlled, randomized clinical trial. Pain Ther 2021; [Online ahead of print].

Nestor CC, Wang S, Irwin MG. Are tracheal intubation and extubation aerosol-generating procedures? Anaesthesia  2021; 76(2): 151-5.

Nestor CC, Kearsley R, Irwin MG. Anaesthetic implications for a malignant hyperthermia‐susceptible fetus. Anaesthesia 2021; 76(9): 1281-82.

Nestor CC, Sepulveda PO, Irwin MG. Drug mixtures and infusion technology. MasterChef or Hell’s Kitchen? Anaesthesia 2021; [Online ahead of print].

Tai WL, Sun LT, Li H, Gu P, Joosten EA, Cheung CW. Additive effects of environmental enrichment and ketamine on neuropathic pain relief by reducing glutamatergic activation in spinal cord injury in rats. Front Neurosci 2021; 15: 635187.

Tsang HYS, Ma KW, She WH, Chu SKF, Lau WHV, Lam SW, Cheung TT, Lo CM. High-intensity focused ultrasound ablation of liver tumors in difficult locations. Int J Hyperthermia 2021; 38(2): 56-64.

Wang L, Cai Y, Jian L, Cheung CW, Zhang L, Xia Z. Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy. Cardiovasc Diabetol; 2021; 20(1): 2.

Wong GTC, Irwin MG. Post-induction hypotension: a fluid relationship? Anaesthesia  2021; 76(1): 15-8.

Wong KW, Lam PK, Sin WC, Irwin MG, Rainer TH. Comparison of the efficiency and usability of aerosol box and intubation tent on intubation of a manikin using personal protective equipment: a randomized crossover study.  J Emerg Med 2021; S0736-4679(21)00556-4.

Xiong W, Xiong SH, Chen QL, Linghu KG, Zhao GD, Chu MT, Wong GTC, Li J, Hu YJ, Wang YT and Yu H. Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs. Carbohydr Polym 2021; 266: 118112.

Xu J, Gao P, Wu Y, Yin S, Zhu L, Xu S, Tang D, Cheung CW, Jiao Y, Yu W, Li Y, Yang L. G protein‐coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain. CNS Neurosci Ther 2021; 27(11):1313-26.

Yeung SC, Ganesan K, Wong SCS, Chung SK, Cheung CW. Characterization of acute pain‐induced behavioral passivity in mice: Insights from statistical modeling. Eur J Neurosci 2021; 53(9):3072-92.

Yeung SC, Irwin MG, Cheung CW. Environmental enrichment in postoperative pain and surgical care: potential synergism with the enhanced recovery after surgery pathway. Ann Surg 2021; 273(1): 86-95.


Bu X, Li T, Wang H, Xia Z, Guo D, Wang J, Sun Y, Yang C, Liu G, Ma J, Yang Z, Wang G. Combination of isoflurane and propofol as general anesthesia during orthopedic surgery of perioperative cerebral hypoperfusion rats to avoid cognitive impairmentFront Med (Lausanne) 2020; 7: 549081.

Cai Y, Ying F, Liu H, Ge L, Song E, Wang L, Zhang D, Tang EHC, Xia Z, Irwin MG. Deletion of Rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of STAT3 signalingFASEB J 2020; 34(3): 4482-96.

Chan EYF, Ip DKY, Irwin MG. Anesthetic Management for Squamous Cell Carcinoma of the EsophagusMethods Mol Biol 2020; 2129: 359-83.

Chan PK, Hwang YY, Cheung A, Yan CH, Fu H, Chan T, Fung WC, Cheung MH, Chan VWK, Chiu KY. Blood transfusions in total knee arthroplasty: a retrospective analysis of a multimodal patient blood management programmeHong Kong Med J 2020; 26(3): 201-07.

Chan SP, Ip KY, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative reviewAnaesthesia 2020; 74 (S1): 80-89.

Chan TCW, Cheung CW, Wong SSC, Chung AYF, Irwin MG, Chan PK, Fu H, Yan CH, Chiu KY. Preoperative dexamethasone for pain relief after total knee arthroplasty: a randomised controlled trialEur J Anaesthesiol 2020; 37(12): 1157-67.

Chen K, Yu J, Wang Q, Wu L, Liu X, Wong GTC, Lu Y. The timing of propofol administration affects the effectiveness of remote ischemic preconditioning induced cardioprotection in ratsJ Cell Biochem 2020; 121(11): 4535-41.

Chok KSH, Hui JYM, Wong GTC. A rare case of propofol-induced acute hepatitis in after a brief Endoscopic Retrograde Cholangio-Pancreatography (ERCP)Surgical Case Reports 2020. 3(2): 1-3.

Chow VLY, Chan JYW, Ho VWY, Pang SSY, Lee GCC, Wong MMK, Lo ASH, Lui F, Poon CMC, Wong STS. Tracheostomy during COVID-19 pandemic – a novel approachHead Neck 2020; 42(7): 1367-73.

Green SM, Leroy PL, Roback MG, Irwin MG, et alAn international multidisciplinary consensus statement on fasting before procedural sedation in adults and childrenAnaesthesia 2020; 75(3): 374-85.

Ho YS, Zhao FY, Yeung WF, Wong GTC, Zhang HQ, Chang RCC. Application of acupuncture to attenuate immune responses and oxidative stress in postoperative cognitive dysfunction: what do we know so far? Oxid Med Cell Longev 2020; 2020: 9641904 1-21.

Irwin MG, Chung CKE, Ip KY, Wiles MD. Influence of propofol-based total intravenous anaesthesia on peri-operative outcome measures: a narrative reviewAnaesthesia 2020; 75(S1): e90-e100.

Irwin MG, Chung CKE, Wong GTC. Measuring the effect-siteAnesthesia 2020; 75(12): 1583-86.

Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)J Gen Intern Med 2020; 35(5): 1545-49.

Khong ML, Chan E, Tanner JA, Lee PPW, Wong GTC. COVID-19 – A covert catalyst for pedagogical stocktake and transformation: perspectives of a global hubMedEdPublish 2020. 9(1): 212.

Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, Zhan LY, Jia Y, Zhang L, Liu D, Xia ZY, Xia Z. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infectionEClinicalMedicine 2020; 21: 100331.

Lei S, Jiang F, Xia ZY, Xia Z. Author's reply - Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infectionEClinicalMedicine 2020; 22: 100363.

Li P, Li X, Deng P, Wang D, Bai X, Li Y, Luo C, Belguise K, Wang X, Wei X, Xia ZY, Yi B. Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly ratsAging (Albany NY) 2020; 13(1): 694-713.

Li YJ, Zhang LG, Zhi HY, Zhong KH, He WQ, Chen Y, Yang ZY, Chen L., Bai XH, Qin XL, Li DF, Wang DD, Gu JT, Ning JL, Lu KZ, Zhang J, Xia ZY, Chen Y, Yi B. A better method for the dynamic, precise estimating of blood/ haemoglobin loss based on deep learning of artificial intelligenceAnn Transl Med 2020; 8(19): 1219.

Li YY, Wang Y, Li Y, Zhong M, Liu H, Wu C, Guo X, Xia Z, Ma W. Comparison of repeated video display vs combined video display and live demonstration as training methods to healthcare providers for donning and doffing personal protective equipment: a randomized controlled trialRisk Manag Healthc Policy 2020; 13: 2325-35.

Liu J, Xie X, Yan D, Wang Y, Yuan H, Cai Y, Luo J, Xu A, Huang Y, Cheung CW, Irwin MG, Xia Z. Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic ratsJ Cell Mol Med 2020; 24(23): 13727-38.

Liu JA, Tai A, Hong J, Cheung MPL, Sham MH, Cheah KSE, Cheung CW, Cheung M. Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilizationProc Natl Acad Sci USA 2020; 117(8): 4199-4210.

Liu Y, Chu JMT, Yan T, Zhang Y, Chen Y, Chang RCC, Wong GTC. Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease miceJ Neuroinflammation 2020; 17(1): 4 .

Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut microbiome fermentation determines the efficacy of exercise for diabetes preventionCell Metab 2020; 31(1): 77-91.

Liu Z, Xu S, Ji Z, Xu H, Zhao W, Xia Z, Xu R. Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stressAging (Albany NY) 2020; 12(13): 13463-76.

Liu Z, Zhao W, Yuan P, Zhu P, Fan K, Xia Z, Xu S. The mechanism of CaMK2α-MCU-mitochondrial oxidative stress in bupivacaine-induced neurotoxicityFree Radic Biol Med 2020; 152: 363-74.

Luo J, Yan D, Li S, Liu S, Zeng F, Cheung CW, Liu H, Irwin MG, Huang H, Xia Z. Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats.  J Cell Mol Med 2020; 24(2): 1760-73.

Peng K, Liu H, Yan B, Meng XW, Song SY, Ji FH, Xia Z. Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosisJ Cell Physiol 2020; 236(2): 1309-20.

Su W, Qiu Z, Zhou L, Hou J, Wang Y, Huang F, Zhang Y, Jia Y, Zhou J, Liu D, Xia Z, Xia ZY, Lei S. Sex differences in clinical characteristics and risk factors for mortality among severe patients with COVID-19: a retrospective studyAging (Albany NY) 2020; 12(19): 18833-43.

Sun LT, Fleetwood-Walker S, Mitchell R, Joosten EA, Cheung CW. Prolonged analgesia by spinal cord stimulation following a spinal injury associated with activation of adult neural progenitorsPain Pract 2020; 20(8): 859-77.

Wang C, Yuan W, Hu A, Lin J, Xia Z, Yang CF, Li Y, Zhang Z. Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injuryMol Med Rep 2020; 22(1): 175-84.

Wang C, Zhu L, Yuan W, Sun L, Xia Z, Zhang Z, Yao W. Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent mannerJ Cell Mol Med 2020; 24(12): 6670-79.

Wang K, Wu C, Xu J, Zhang B, Zhang X, Gao Z, Xia Z, Factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: a systematic review and meta-analysisEClinicalMedicine 2020; 29: 100612.

Wang S, Ge L, Zhang D, Wang L, Liu H, Ye X, Liang W, Li J, Ma H, Cai Y, Xia Z. MiR-181c-5p promotes inflammatory response during hypoxia/reoxygenation injury by downregulating protein tyrosine phosphatase nonreceptor type 4 in H9C2 cardiomyocytesOxid Med Cell Longev 2020; 2020: 7913418.

Wang SYS, Zhu S, Wu J, Zhang M, Xu Y, Xu W, Cui J, Yu B, Cao W, Liu J. Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathyJ Mol Med (Berl) 2020; 98(2): 245-61.

Wang XM, Gu P, Saligan L, Iadarola M, Wong SCS, Ti LK, Cheung CW. Dysregulation of EAAT2 and VGLUT2 spinal glutamate transports via histone Ddacetylase 2 (HDAC2) Ccntributes to paclitaxel-induced painful neuropathyMol Cancer Ther 2020; 19(10): 2196-209.

Wang XX, Sha X, Liu Y, Li C, Chen S, Wang J, Xia Z. Lung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in ratsBMC Anesthesiol 2020; 20(1): 188.

Wang Y, Zhou L, Su W, Huang F, Zhang Y, Xia ZY, Xia Z, Lei S. Selective inhibition of PKCβ2 restores ischemic postconditioning-mediated cardioprotection by modulating autophagy in diabetic ratsJ Diabetes Res 2020; 2020: 2408240.

Wong SSC, Chan WS, Cheung CW. Analgesic effects of cannabinoids for chronic non-cancer pain: a systematic review and meta-analysis with meta-regressionJ Neuroimmune Pharmacol 2020;15(4): 801-9 Review.

Wong SSC, Chan WS, Fang C, Chan C, Lau TW, Leung F, Cheung CW. Infraclavicular nerve block reduces postoperative pain after distal radial fracture fixation: a randomized controlled trialBMC Anesthesiology 202020(1): 130.

WongSSC, Chan WS, Irwin MG, Cheung CW. Total intravenous anesthesia (TIVA) with Propofol for acute postoperative pain: a scoping review of randomized controlled trialsAsian J Anesthesiol 2020; 58(3): 79-93.

Wong SS, Cheung CW. Optimization of opioid utility in cancer pain populationsAnn Palliat Med 2020; 9(2): 558-70.

Wong SSC, Cheung CW. Analgesic efficacy and adverse effects of Meperidine in managing postoperative or labor pain: a narrative review of randomized controlled trialsPain Physician 2020; 23(2): 175-201.

Wu B, Hong H, Xia Z, Liu H, Chen X, Chen J, Yan B, Liang Y. Transcriptome analyses unravel CYP1A1 and CYP1B1 as novel biomarkers for disinfection by-products (DBPs) derived from chlorinated algal organic matterJ Hazard Mater 2020; 387: 121685.

Xia Z. Eosinopenia as an early diagnostic marker of COVID-19 at the time of the epidemicEClinicalMedicine 2020; 23: 100398.

Yan D, Cai Y, Luo J, Liu J, Li X, Ying F, Xie X, Xu A, Ma X, Xia Z. FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetesJ Cell Mol Med 2020; 24(14): 7850-61.

Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, Zhang W, Zhang W, Li X. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosisCell Death Dis 2020; 11(10): 827.

Yang X, Hu F, Liu JA, Shan Y, Cheung MPL, Liu XL, Ng IOL, Guan XY, Wong KKW, Sharma R, Lung HL, Jiao YF, Lee LTO, Cheung M. Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanomaOncogene 2020. 39(20): 4061-76.

Ye QP, Wu D, Fang WP, Wong GTC, Lu Y. Comparison of gastric insufflation using LMA-supreme and I-gel versus tracheal intubation in laparoscopic gynecological surgery by ultrasound: a randomized observational trialBMC Anesthesiol 2020, 20(1): 136.

Zhang D, He Y, Ye X, Cai Y, Xu J, Zhang L, Li M, Liu H, Wang S, Xia Z. Activation of autophagy inhibits nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic ratsJ Diabetes Investig 2020; 11(5): 1126-36.

Zhang D, Mei L, Long R, Cui C, Sun Y, Wang S, Xia Z. RiPerC attenuates cerebral ischemia injury through regulation of miR-98/PIK3IP1/PI3K/AKT signaling pathwayOxidMed Cell Longev 2020; 2020: 645428.

Zhu Q, Li H, Xie X, Chen X, Kosuru R, Li S, Lian Q, Cheung CW, Irwin MG, Ge RS, Xia ZAdiponectin facilitates postconditioning cardioprotection through both AMPK-dependent nuclear and AMPK-independent mitochondrial STAT3 activationOxid Med Cell Longev 2020; 2020: 4253457.


Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG et alPerioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicineBr J Anaesth 2019; 122(5): 542-51.

Chan SP, Ip KY, Irwin MG. Peri-operative optimization of elderly and frail patients: a narrative reviewAnaethesia 2019; 74 (S1): 80-9.

Chen K, Wang L, Wang Q, Liu X, Lu Y, Li Y, Wong GTC. Effects of pneumoperitoneum and steep trendelenburg position on cerebral hemodynamics during robotic-assisted laparoscopic radical prostatectomy: a randomized controlled studyMedicine 2019; 98(21): e15794.

Cheung CW. Epidural steroids – are we following the guidelines? Anaesthesia 2019; 74(12): 1500-03.

Cheung VYT, Lam TPW, Jenkins CR, Lam SW, Cheung GKI, Chan SSY, Choi WK. Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine fibroids: a preliminary experienceJ Obstet Gynaecol 2019; 39(6): 833-9.

Cheung V, Yuen VMY, Wong GTC, Choi SW. The effect of sleep deprivation and disruption on DNA damage and health of doctorsAnaesthesia 2019, 74(4): 434-40.

Chow LWC, Cheng KS, Leong F, Cheung CW, Shiao LR, Leung YM, Wong KL. Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP productionNaunyn Schmiedebergs Arch Pharmacol 2019; 392(4): 427-36.

Ge L, Cai Y, Ying F, Liu H, Zhang D, He Y, Pang L, Yan D, Xu A, Ma H, Xia Z. miR-181c-5p exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis via targeting PTPN4Oxid Med Cell Longev 2019; 2019: 1957920.

Ge ZD, Lian Q, Mao X, Xia Z. Current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathyInt Heart J 2019; 60(3): 512-20.

Huang C, Ng OT, Chu JM, Irwin MG, Hu X, Zhu S, Chang RC, Wong GT. Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult miceNeurosci Lett 2019; 707: 134309.

Ip KY, Tsai NWP, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative reviewAnaesthesia 2019; 74 (S1): 80-9.

Irwin MG, Chung CKE, Ip KY, Wiles MD. Influence of propofol-based total intravenous anaesthesia on peri-operative outcome measures: a narrative reviewAnaesthesia 2020, 75(S1): e90-e100.

Irwin MG, Ip KY, Hui YM. Anaesthetic considerations in nonagenarians and centenariansCurr Opin Anaesthesiol 2019, 32(6): 776-82.

Irwin MG, Wong GTC. Taking on TIVA. Why we need guidelines on total intravenous anaesthesiaAnaesthesia 2019; 74(2): 140-2.

Kumar CM, Seet E, Eke T, Irwin MG, Joshi GP. Peri-operative considerations for sedation-analgesia during cataract surgery: a narrative reviewAnaesthesia 2019; 74(12), 1601-10.

Lee LKK, Tsai NWP, Ip KY, Irwin MG. Pre-operative cardiac optimization: a directed reviewAnaesthesia 2019; 74(S1): 67-9.

Liu Y, Yan T, Chu MT, Chen Y, Dunnett SL, Ho YS, Wong GTC, Chang RCC. The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseasesLab Invest 2019; 99(7): 943-57.

Lei S, Su W, Xia ZY, Wang Y, Zhou L, Qiao S, Zhao B, Xia Z, Irwin MG. Hyperglycemia-induced oxidative stress abrogates remifentanil preconditioning-mediated cardioprotection in diabetic rats by impairing Caveolin-3-modulated PI3K/Akt and JAK2/STAT3 signalingOxid Med Cell Longev 2019; 2019: 9836302.

Liu Y, Paterson M, Baumgardt SL, Irwin MG, Xia Z, Bosnjak ZJ, Ge ZD. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioningCardiovasc Res 2019; 115(1):168-78.

McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F et alPerioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgeryBr J Anaesth 2019; 122(5): 575-86.

Qin Z, Xiang C, Li H, Liu T, Zhan L, Xia Z, Zhang M, Lai J. The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trialBMC Anesthesiol 2019; 19(1): 181.

Sanders RD, Hughes F, Shaw A, Thompson A, Bader A et alPerioperative quality initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgeryBr J Anaesth 2019; 122(5): 552-62.

Sessier DI, Blookstone JA, Aronson S, Berry C, Gan T et alPerioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgeryBr J Anaesth 2019; 122(5): 563-74.

Shi DD, Huang YH, Lai CSW, Dong CM, Ho LC, Li XY, Wu EX, Li Q, Wang XM, Chen YJ, Chung SK, Zhang Z. Ginsenoside Rg1 prevents chemotherapy-induced cognitive impairment: associations with microglia-mediated cytokines, neuroinflammation, and neuroplasticityMol Neurobiol 2019; 56(8): 5626-42.

Song SY, Meng XW, Xia Z, Liu H, Zhang J, Chen QC, Liu HY, Ji FH, Peng K. Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevofluraneAging (Albany NY) 2019;11(19): 8386-8417.

Sun L, Ma W, Gao W, Xing Y, Chen L, Xia Z, Zhang Z, Dai Z. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasomeCell Death Dis  2019; 10(8): 542.

Tsai NW, Leung YM, Ng PY. Liong T, Lee SF, Ngai CW, Sin WC, Koo J, Chan WM. Attitudes of visitors at adult intensive care unit toward organ donation and organ supportChin Med J (Engl) 2019; 132(3): 373-6.

Ward PA, Irwin MG. Airway management research and the need for consensusAnaesthesia 2019; 74(7): 942.

Wang TT, Shi MM, Liao XL, Li YQ, Yuan HX, Li Y, Liu X, Ning DS, Peng YM, Yang F, Mo ZW, Jiang YM, Xu YQ, Li H, Wang M, Ou ZJ, Xia Z, Ou JS. Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioningJ Mol Cell Cardiol 2019; 129: 144-53.

Wong SCS, Lee UM, Wang XMA, Chung SK, Cheung CW. Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in miceNeurosci Lett 2019; 709: 134379.

Wong SCS, Leung MYY, Cheung CW. The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trialEur J Pain 2019; 23(5): 884-93.

Wong SCS, Sun LT, Qiu Q, Gu P, Li Q, Wang XMA, Cheung CW. Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative painEur J Pain 2019; 23(4): 812-22.

Wu B, Hong H, Xia Z, Liu H, Chen X, Chen J, Yan B, Liang Y. Transcriptome analyses unravel CYP1A1 and CYP1B1 as novel biomarkers for disinfection by-products (DBPs) derived from chlorinated algal organic matterJ Hazard Mater 2019; 12: 121685

Xiong W, Zhao GD, Yin X, Linghu KG, Chu MT, Wong GTC, Li H, Yu H, Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigationsCarbohydr Polym 2019; 204: 89-96.

Ye X, Zhang D, Wang S, Irwin MG, Xia Z. Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injuryThe FASEB J 2019; 33(S1): A514.11.

You R, Liu Y, Chang RCC. A behavioral test battery for the repeated assessment of motor skills, mood, and cognition in miceJ Vis Exp 2019: 145

Yuen VMY, Cheuk DK, Hui TW, Wong IC, Lam WW, Irwin MG. Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicenter studyHong Kong Med J 2019; 25(S3): 27-9.

Zhu D, Fan T, Huo X, Cui J, Cheung CW, Xia Z. Progressive increase of inflammatory CXCR4 and TNF-Alpha in the dorsal root ganglia and spinal cord maintains peripheral and central sensitization to diabetic neuropathic pain in ratsMediators Inflamm 2019; 2019: 4856156.


Chang L, Ye F, Luo Q, Wang Z, Wang Y, Xia Z, Shu H. Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesiaBioSci Trends 2018; 12(2): 177-184.

Chen X, Wang Y, Xie X, Chen H, Zhu Q, Ge Z, Wei H, Deng J, Xia Z, Lian Q. Heme oxygenase-1 reduces sepsis-induced endoplasmic reticulum stress and acute lung injuryMediator Inflamm 2018; 2018: 9413876(1-10).

Choi SW, Charlesworth M, Wong GTC. A good pilot to navigate troubled watersAnaesthesia 2018; 73(4): 512-4.

Choi SW, Leung FKL, Lau TW, Wong GTC. Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative managementHIP Int 2019; 29(2): 172-6.

Choi SW, Wong GTC. Doctor, why are you driving a wedge between us? Calculating sample size in multiple testing and the need for Geisser-Greenhouse correctionAnaesthesia 2018; 73(12): 1564-66.

Choi SW, Wong GTC. Quality improvement studies - pitfalls of the before and after study designAnaesthesia 2018; 73(11): 1432-35.

Choi SW, Wong GTC. Assumptions and associations under pressureAnaesthesia 2018; 73(7): 901-3.

Choi SW, Wong GTC. The art and science of statistical predictions: does a picture need a thousand words? Anaesthesia 2018; 73(6): 784-7.

Choi SW, Wong GTC. Before and after studies and historical controls. Is the proof in the pudding? Anaesthesia 2018; 73(5): 642-4.

Choi SW, Wong GTC. Big data, big problems: causation, confounders and cohortsAnaesthesia 2018; 73(3): 384-7.

Chu JMT, Xiong W, Linghu KG, Liu Y, Zhang Y, Zhao GD, Irwin MG, Wong GTC, Yu H. Siegesbeckia Orientalis L. Extract attenuates postoperative cognitive dysfunction, systemic inflammation, and neuroinflammationExp Neurobiol 2018; 27(6): 564-73.

Ge L, Ma H, Cai Y, Pang L, Irwin MG, Xia Z. MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenationFASEB J 2018; 32(S1): A698.10.

Greenland K.B. and Irwin MG. Big data: breaking new ground in airway researchAnaesthesia 2018; 73(6): 674-8.

He Y, Cai Y, Yan D, Zhang D, Chen C, Irwin MG, Wang S, Xia Z. MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signalingFASEB J 2018; 32(S1): lb595.

Ho RHY, Irwin MG. Anaesthesia for surgery major spinal. Anaesthe Intensive Care Med 2018; 19(4): 159-63.

Huang C, Irwin MG, Wong GTC, Chang RCC. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal modelJ Neuroinflammation 2018; 15(1): 147.

Huang C, Chu JM, Liu Y, Chang RCC, Wong GTC. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged miceNeuropharmacology 2018; 143: 217-27.

Jin SY, Huang J, Zhu HJ, Wu H, XU SJ, Irwin MG, He SF, Zhang Y. Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heartEur J Pharmacol 2018; 828: 1-8.

Kosuru R, Cai Y, Kandula V, Yan D, Wang C, Zheng H, Li Y, Irwin MG, Singh S, Xia Z. AMPK contributes to cardioprotective effects of pterostilbene against myocardial ischemia- reperfusion injury in diabetic rats by suppressing cardiac oxidative stress and apoptosisCell Physiol Biochem 2018; 46(4): 1381-97.

Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic ratsCardiovasc Drugs Ther 2018; 32(2): 147163.

Kwok DHY, Irwin MG. Preoperative assessment of the orthopaedic patient. Anaesthe Intensive Care Med 2018; 19(4): 151-4.

Lam WL, Yeung WF, Wong MK, Cheung CW, Chan KKL, Ngan HYS, Wong CKH, Chen H, Lao L. Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trialTrials 2018; 19(1): 8.

Lau YC, Irwin MG. Anaesthesia for joint replacement surgery. Anaesthe Intensive Care Med 2018; 19(4): 171-4.

Li A, Yuen VM, Goulay-Dufay S, Sheng Y, Standing JF, Kwok PCL, Leung AS, Wong ICK, Irwin MG. Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidineBr J Anaesth 2018; 120(5): 960-8.

Li H, Irwin MG, Xia Z. Hyperglycemia-induced protein kinase Cβ2 activation causes diastolic cardiac dysfunction by disrupting Brg1-mediated suppression of RIP3 in diabetic ratsFASEB J 2018; 32(S1): A673.3.

Liu J, Yan D, Xie X, Xia Z. FOXO1 couples reactive oxygen species in diabetic atherosclerosisFASEB J 2018; 32(S1): A569.8.

Lu Y, Dai WC, Zong Z, Xiao Y, Wu DI, Liu X, Wong GTC. Bronchial blocker versus left double-lumen endotracheal tube for one-lung ventilation in right video-assisted thoracoscopic surgery.  J Cardiothorac Vasc Anesth 2018; 32(1): 297-301.

Mohtar S, Hui TWC, Irwin MG. Anesthetic management of thoracoscopic resection of lung lesions in small childrenPaediatr Anaesth 2018; 28(11): 1035-42.

Mu JJ, Jiang T, Deng LP, Choi SW, Irwin MG, Yuen VMY. A comparison of two techniques for induction of anaesthesia with target-controlled infusion of propofolAnaesthesia 2018; 73(12): 1507-14.

Mu J, Jiang T, Xu XB, Yuen VMY, Irwin MG. Comparison of target-controlled infusion and manual infusion for Propofol anaesthesia in childrenBr J Anaesth 2018; 120(5): 1049-55.

Pandit JJ, Irwin MG. Difficult airway society guidelines on the airway management of critically ill patients. A replyAnaesthesia 2018; 73(8): 1036-37.

Pandit JJ, Irwin MG. Airway management in critical illness: practice implications of new Difficult Airway Society guidelinesAnaesthesia2018; 73(5): 544-8.

Shi DD, Ding M, Ho LC, Lam CTW, Zhou XD, Wu EX, Zhou ZJ, Wang XM, Zhanf ZJ. Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: involvement of cytokine modulation and neuroprotectionNeurobiol Dis 2018; 114: 164-73.

Smith AS, Irwin MG. Researching researchAnaesthesia 2018; 73(6): 668-71.

Tai WL, Pan Z, Sun LT, Li H, Gu P, Wong SCS, Chung SK, Cheung CW. Suppression of Pax2 attenuates allodynia and hyperalgesia through ET-1–ETAR–NFAT5 signaling in a rat model of neuropathic painNeuroscience 2018; 384: 139-51.

Wong D, Tsai PNW, Ip KY, Irwin MG. New antihypertensive medications and clinical implicationsBest Pract Res Clin Anaesthesiol 2018; 32(2): 223-35.

Wong ESW, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PMGR. L-arginine and arginase products potentiate dexmedetomidine-induced contractions in the rat aortaAnesthesiology 2018; 128: 564-73.

Wong KHK, Cai Y, Ying F, Chen X, Vanhoutte PM, Tang EHC. Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxationsJ Mol Cell Cardiol 2018; 115: 1-9.

Wong GTC. Patient emergence – statistical questionsAnaesthesia 2018; 73(1): 130.

Wong GTC, Choi SW, Tran DHD, Kulkarni H, Irwin MG. An international survey evaluating factors influencing the use of total intravenous anaesthesiaAnaesth Intensive Care 2018; 46(3): 332-8.

Wong GTC, Irwin MG. A cost comparison between total intravenous and volatile anaesthesia. Anaesth Intensive Care 2018; 46(6): 633-4.

Wong SCS, Qiu Q, Cheung CW. Segmental spinal myoclonus complicating lumbar transforaminal epidural steroid injectionReg Anesth Pain Med 2018; 43(5): 554-6.

Wong SCS, Irwin MG. Anaesthesia and minimally invasive surgery. Anaesth Intensive Care Med 2018; 19(1): 11-5.

Wong SCS, Irwin MG. Procedures under tourniquet. Anaesthe Intensive Care Med 2018; 19(4): 155-8.

Wong SCS, Choi SW, Cheung CW. A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong chinese population: an analysis of pain related outcomes and patient help seeking behaviourPLoS One 2018; 13(10): e0204054.

Wong SCS, Choi SW, Lee Y, Irwin MG, Cheung CW. The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgeryMedicine 2018; 97(31): e11615.

Xie X, Yan D, Li H, Zhu Q, Li J, Fang YP, Cheung CW, Irwin MG, Xia Z, Lian Q. Enhancement of adiponectin ameliorates nonalcoholic fatty liver disease via inhibition of FoxO1 in type I diabetic ratsJ Diabetes Res 2018; 2018: 6254340(1-9).

Xiong W, Zhao GD, Yin X, Linghu KG, Chu MT, Wong GTC, Li H, Yu H, Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigationsCarbohydr Polym 2019; 204: 89-96.

Yan D, Cai Y, Luo J, Liu J, Irwin MG, Xia Z. Pharmacologic inhibition of FOXO1 improves cardiac function by enhancing glucose metabolism and attenuating apoptosis in type-1 diabetic ratsFASEB J 2018; 32(S1): A838.2.

Ye XD, He Y, Wang S, Wong GTC, Irwin MG, Xia Z. Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosisActa Pharmacol Sin 2018; 39(7): 1155-63.

You R, Ho YS, Hung HLC, Liu Y, Huang C, Chan HN, Ho SL, Lui SY, Li HW, Chang RCC. Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activationPart Fibre Toxicol 2018; 15(1): 28.

Ying F, Cai Y, Tang EHC, Xia Z. Deficiency of prostaglandin E2 receptor subtype 4 exacerbates left ventricular remodeling and myocardial fibrosis in diet-induced mice. FASEB J 2018; 32(S1): lb600.

Ying F, Cai Y, Wong HK, CHen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A, Tang EHC. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemiaBiochim Biophys Acta Mol Cell Biol Lipids 2018; 1863(9): 1029-40.

Zhang C, Luo Q, Li Y, Wu X, Hao Z, LI S, Xia Z, Yan F, Sun L. Predictors of short-term outcomes following repair of anomalous origin of the left coronary artery from the pulmonary artery in Chinese children: a case-control studyJ Cardiothorac Vasc Anesth 2018; 32(6): 2644-51.



Cai Y, Kosuru R, Ye X, Irwin MG and Xia Z.Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.Cell Cycle2017; 16(19): 1765-73.

Chan LK, Ganotice FJr, Wong FKY, Lau CS, Bridges SM, Chan CHY, Chan N, Chan PWL, Chen HY, Chen JY, Chu JKP, Ho CC, Ho JMC, Lam TP, Lam VSF, Li Q, Shen JG, Tanner JA, Tso WWY, Wong AKC, Wong GTC, Wong JYH, Wong NS, Worsley A, Yu LK and Yum TP.Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning.BMC Med Edu. 2017; 17(1): 221.

Cheng Y, Feng Y, Xia Z, Li X and Rong J.ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS.Biochim Biophys Acta. 2017; 1862(12): 1595-1605.

Cheung CW, Wong SCS, Qiu Q and Wang XMA.Oral oxycodone for acute postoperative pain: a narrative review of clinical trials.Pain Physician. 2017; 20(2S): SE33-SE52.

Cheung CW, Choi SW, Wong SSC, Lee Y and Irwin MG.Changes in prevalence, outcomes and help-seeking behavior of chronic pain in an aging population over the last decade.Pain Practice2017; 17(5): 643-54.

Choi SW, Lam DM, Wong SCS, Shiu HC, Wang XMA and Cheung CW.Effects of Single Nucleotide Polymorphisms on Surgical and Post-surgical Opioid Requirements - A Systematic Review and Meta-analysis.Clin J Pain. 2017; 33(12): 1117-30.

Gao S, Zhan L, Yang Z, Shi R, Li H, Xia Z, Yuan S, Wu QP, Wang T and Yao S.Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling.Cell Physiol Biochem. 2017; 43(3): 1140-51.

Greenland KB, Bradley WPL, Chapman GA, Goulding G and Irwin MG.Emergency front-of-neck access: scalpel or cannula-and the parable of Buridan's ass.Br J Anaesth. 2017; 118(6): 811-4.

Greenland KB, Bradley WPL, van Zundert A and Irwin MG.Airway assessment/management paradigm - does a spectral or a binary approach fit better?Anaesthesia2017; 72(8): 1035-37.

Hou YY, Li Y, He SF, Song J, Yu DX, Wong GTC and Zhang Y.Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design.J Clin Anesth. 2017; 41: 21-28.

Kong KFV, Jian CJ, Ji R and Irwin MG.Management of an incidental finding of right internal jugular vein agenesis.Hong Kong Med J. 2017; 23(4): 414-5.

Li MJ, Li M, Liu Z, Yan B, Pan Z, Huang D, Liang Q, Ying D, Xu F, Yao H, Wang P, Kocher JA, Xia Z, Sham PC, Liu JS and Wang JJ.cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes.Genome Biol. 2017; 18(1): 52.

Lu J, Yao X, Luo X, Wang Y, Chung SK, Tang H, Cheung CW, Wang X, Meng C and Li Q.Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells.Neural Regen Res. 2017; 12(6): 945-52.

Qiu Q, Sun L, Wang XM, Lo ACY, Wong K, Gu P, Wong SCS and Cheung CW.Propofol produces preventive analgesia via GluN2B-containing NMDA Receptor/ERK1/2 signaling pathway in the rat model of inflammatory pain.Mol Pain. 2017; 13: 1744866917737462.

Scott HB, Choi SW, Wong GTC and Irwin MG.The effect of remifentanil on propofol requirements to achieve loss of response to command vs. loss of response to pain.Anaesthesia2017; 72(4): 479-87.

Sun LT, Tai L, Qiu Q, Mitchell R, Fleetwood-Walker S, Joosten EAJ and Cheung CW.Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation.Eur J Pain. 2017; 21(5): 804-14.

Tian G, LUO X, Tang C, Cheng X, Chung SK, Xia Z, Cheung CW and Guo Q.Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome.Life Sciences2017; 170: 64-71.

Veniaminova E, Cespuglio R, Cheung CW, Umriukhin A, Markova N, Shevtsova E, Lesch KP, Anthony DC and Strekalova T.Autism-like behaviours and memory deficits result from a western diet in mice.Neural Plast. 2017; 2017: 9498247.

Wang L, Zhou MT, Chen CY, Yin W, Wen DX, Cheung CW, Yang LQ and Yu WF.Increased renal clearance of rocuronium compensates for chronic loss of bile excretion, via upregulation of Oatp2.Sci Rep. 2017; 7: 40438.

Wong GTC, Ang WC, Wong CLT and Choi SW.Surgical Outcome Risk Tool (SORT) validation in hepatectomy.Anaesthesia2017; 72(10): 1287-89.

Wong SCS, Chan TCW and Cheung CW.Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice.Hong Kong Med J. 2017; 23(5): 517-23.

Yao W, Li H, Han X, Chen C, Zhang Y, Tai WL, Xia Z and Hei Z.MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro.J Cell Mol Med. 2017; 21(10): 2503-13.

Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z and Hei Z.SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction.Free Radic Biol Med. 2017; 108: 542-53.

Ying F, Cai Y, Cai Y, Wang Y and Tang EHC.Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue.FASEB J. 2017; 331(9): 4023-36.

Yuen VMY, Li BL, Cheuk DK, Leung MKM, Hui TWC, Wong IC, Lam WW, Choi SW and Irwin MG.A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children.Anaethesia2017; 72(10): 1191-95.

Yuen VMY, Wong CHP, Wong SCS and Wong GTC.Rescue oxygenation in small infants.Anaesthesia2017; 72(12): 1564-65.

ZhaoY, Zheng ZN, Cheung CW, Zuo ZY and Jin SQ.Transfusion of plasma collected at late phase after preconditioning reduces myocardial infarct size induced by ischemia-reperfusion in rats in vivo.Chin Med J (Engl). 2017; 130(3): 303-8.



Cao S., Liu Y., Wang H., Mao X., Chen J., Liu J., Xia Z., Zhang L., Liu X. and Yu T.,Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts,PeerJ. 2016, 4: e1706.

Cheng Y., Xia Z., Han Y. and Rong J.,Plant natural product formononetin protects rat cardiomyocyte H9c2 cells against oxygen glucose deprivation and reoxygenation via inhibiting ROS formation and promoting GSK-3β phosphorylation,Oxid Med Cell Longev. 2016, 2016: 2060874.

Chan A.C., Qiu Q., Choi S.W., Wong S.C.S., Chan A.C.Y., Irwin M.G. and Cheung C.W.,Effects of intra-operative total intravenous anaesthesia with Propofol versus inhalational anaesthesia with Sevoflurane on post-operative pain in liver surgery: a retrospective case-control study,PLOS One. 2016, 11: e0149753.

Luo X., Wang X.M.A., Xia Z., Chung S.K. and Cheung C.W.,CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain,Rev Neurosci.2016, 27(1): 83-92.

Wong S.C.S. and Irwin M.G.,Peri-operative cardiac protection for non-cardiac surgery,Anaesthesia. 2016, 71 S1: 29-39.

Cheung C.W., Chan T.C.W., Chen P.P., Chu M.C., Chui W.C.M., Ho P.T., Lam F., Law S.W., Lee J.L.Y., Wong S.H.S. and Wong V.K.C.,Opioid therapy for chronic non-cancer pain: guidelines for Hong Kong.Hong Kong Med J. 2016, 22(5): 496-505.

Cheung C.W.,Prescription drug monitoring programs needed to manage opioid use in Asia Pacific,Pain Pract. 2016, 16(5): E93.

Choi S.W. and Cheung C.W.,Don't judge a book by its cover, don't judge a study by its abstract. Common statistical errors seen in medical papers,Anaesthesia. 2016, 71(7): 843-5.

Choi S.W., Lam D.M. and Irwin M.G.,Ghost in the machine,Hong Kong Med J. 2016, 22(3): 292-3.

Choi S.W. and Wong G.T.C.,It's just a standard deviation!Anaesthesia. 2016, 71(8): 969-71.

Chu M.T., Lee D.K.M., Wong D.P.K., Wong G.T.C. and Yue K.K.M.,Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals,Metab Brain Dis. 2016, 31(5): 1055-64.

Gao S., Yang Z., Shi R., Xu D., Li H., Xia Z., Wu Q.P., Yao S., Wang T. and Yuan S.,Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling,Eur J Pharmacol. 2016, 779: 111-21.

Gao S., Zhu Y., Li H., Xia Z., Wu Q., Yao S., Wang T. and Yuan S.,Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation,Int Immunopharmacol. 2016, 38: 395-401.

Huang C., Ng O.T.W., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C.,Effect of continuous propofol infusion in rat on tau phosphorylation with or without temperature control,J Alzheimers Dis. 2016, 51(1):213-26.

Han X., Yao W., Liu Z., Li H., Zhang Z.J., Hei Z. and Xia Z.,Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner,Oxid Med Cell Longev. 2016, 2016: 9303606.

Kandula V., Kosuru R., Li H., Yan D., Zhu Q., Lian Q., Ge R.S., Xia Z. and Irwin M.G.,Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy,Cardiovasc Diabetol. 2016, 15: 44.

Li A., Yuen V.M.Y., Dufay S. and Kwok P.C.L.,Pharmacokinetics and pharmacodynamics of dexmedetomidine,Drug Dev Ind Pharm. 2016, 42(12):1917-27.

Li B.L., Zhang N., Huang J.X., Qiu Q.Q., Tian H., Ni J., Song X.R., Yuen V.M.Y. and Irwin M.G.,A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops,Anaesthesia. 2016, 71(5): 522-8.

Li H., Yao W., Liu Z., Xu A., Huang Y., Ma X., Irwin M.G. and Xia Z.,Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats,Diabetes. 2016, 65(4): 942-55.

Li M.J., Liu Z., Wang P., Wong M.P., Nelson M.R., Kocher J.P.A., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J.,GWASdb v2: an update database for human genetic variants identified by genome-wide association studies,Nucleic Acids Res. 2016, 44(D1): D869-76.

Lin J., Wang T., Li Y., Wang M., Li H., Xia Z. and Irwin M.G.,N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats,J Diabetes Res. 2016, 2016: 9213034.

Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W.,Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain,Mol Pain. 2016, 12: 1-15.

McLintic A.J. and Irwin M.G., Is the injury out on consensus opinion?Anaesthesia. 2016, 71(3): 256-60.

Pang L., Cai Y., Tang E.H.C., Yan D., Li H., Irwin M.G., Ma H., Xia Z. and Ramoji K.,COX-2 inhibition protects against hypoxia/reoxygenation-induced cardiomyocyte apoptosis via Akt-dependent enhancentment of iNOS expression,Oxid Med Cell Longev. 2016, 2106: 3453059.

Pang L., Cai Y., Tang E.H.C., Irwin M.G., Ma H. and Xia Z.,Prostaglandin E receptor subtype 4 signaling in the heart: role in ischemia/reperfusion injury and cardiac hypertrophy,J Diabetes Res. 2016, 2016: 1324347.

Qiu Q., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W.,Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis,Anaesthesia. 2016. 71(10): 1222-33.

Qiao S., Mao X., Wang Y., Lei S., Liu Y., Wang T., Wong G.T.C., Cheung C.W., Xia Z. and Irwin M.G.,Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the janus activated kinase-2/signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3β in rats,Crit Care Med. 2016, 44(3): e131-45.

Samartzis D., Bow H.Y.C., Cheung J.P.Y., Sham P.L.M., Mak K.C., Cheung W.Y., Wong Y.W., Luk K.D.K., Cheung K.M.C. and Law Min J.,Efficacy of postoperative pain management using continuous local anesthetic infusion at the iliac crest bone graft site in patients with adolescent idiopathic scoliosis: a parallel, double-blinded, randomized controlled pilot trial,Global Spine Journal.2016, 6(3):220-8.

She W.H., Cheung T.T., Jenkins C.R. and Irwin M.G.,Clinical applications of high-intensity focused ultrasound,Hong Kong Med J. 2016, 22(4): 382-92.

Wang Y., Li H., Huang H., Liu S., Mao X., Wang S., Wong S.S.C., Xia Z. and Irwin M.G.,Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling,Clin Sci (Lond). 2016, 130(10): 801-12.

Wang L., Wang T., Li H., Liu Q., Zhang Z., Xie W., Feng Y., Socorburam T., Wu G., Xia Z. and Wu Q.,Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice,PLoS One. 2016, 11(5): e0155723.

Wang Y., Song E., Bai B. and Vanhoutte P.M.,Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes,Pharmacol Ther. 2016, 158: 91-100.

Wong G.T.C., Lee E.Y.P. and Irwin M.G.,Contrast induced nephropathy in vascular surgery,Br J Anaesth. 2016, 117(S2): ii63-73.

Wong S.C.S. and Irwin M.G.,Peri-operative cardiac protection for non-cardiac surgery,Anaesthesia. 2016, 71(S1): 29-39.

Xia Z., Li H. and Irwin M.G.,Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans,Br J Anaesth. 2016, 117(S2): ii44-62.

Xue R., Lei S., Xia Z., Wu Y., Meng Q., Zhan L., Su W., Liu H., Xu J., Liu Z., Zhou B. and Xia Z.,Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways,Clin Sci (Lond). 2016, 130(5): 377-92.

Ye X., He Y., Xia Z. and Wang S.,Fetal descending aortic flow and heart rate monitoring with transesophageal echocardiography during maternal cardiac surgery,Can J Anaesth. 2016, 63(4): 492-4.

Yu EH, Tran DH, Lam SW and Irwin MG.Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain?Anaesthesia2016; 71(11): 1347-62.

Zhuang H., Tian W., Li W., Zhang X., Wang J., Yang Y., Liu X., Xia Z., Feng D. and Zhang L.,Autophagic cell death and apoptosis jointly mediate cisatracurium besylate-induced cell injury,Int J Mol Sci. 2016, 17(4): 515.



Au A.H.Y., Choi S.W., Cheung C.W. and Leung Y.Y.,The efficacy and clinical safety of various analgesic combinations for post-operative pain after third molar surgery: a systematic review and meta-analysis,PLoS One.2015, 10(6): e0127611.

Cheung A.H.K., Li L.F., So V.C., Leung M.K.M. and Lui W.M.,Transient monoplegia and paraesthesia after an epidural blood patch for a spinal cerebrospinal fluid leak,J Clin Neurosci.2015, 22(9): 1493-5.

Cheung C.W., Qiu Q., Liu J., Chu K.M. and Irwin M.G.,Intranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial,Acta Anaesthesiol Scand. 2015, 59(2): 215-23.

Hung K.L., Tai W.L., Luo X., Xiao M.W., Chung S.K. and Cheung C.W.,Targeted over-expression of astrocytic endothelin-1 attenuates neuropathic pain by up-regulating spinal excitatory amino acid transporter-2,J Mol Neurosci.2015, 57(1): 90-6.

Chow K.Y., Liu S.E. and Irwin M.G.,New therapy in cardioprotection,Curr Opin Anaesthesiol.2015, 28(4): 417-23.

Gan X., Xing D., Su G., Li S., Luo G., Irwin M.G., Xia Z., Li H. and Hei Z.,Propofol attenuates small intestinal ischemia reperfusion injury through inhibiting NADPH oxidase mediated mast cell activation,Oxid Med Cell Longev.2015, 2015: 167014.

Huang C., Ho Y.S., Ng O.T., Irwin M.G., Chang R.C. and Wong G.T.,Dexmedetomidine directly increases tau phosphorylation,J Alzheimers Dis. 2015, 44(3): 839-50.

Irwin M.G. and Wong G.T.C.,Remifentanil and opioid-induced cardioprotection,J Cardiothorac Vasc Anesth.2015, 29(S1): S23-6.

Jiang Y., Zhou Z., Meng Q.T., Sun Q., Su W., Lei S., Xia Z. and Xia Z.Y.,Ginsenoside Rb1 treatment attenuates pulmonary inflammatory cytokine release and tissue injury following intestinal ischemia reperfusion injury in mice,Oxid Med Cell Longev.2015, 2015: 843721.

Lam D.M., Choi S.W., Wong S.C.S., Irwin M.G. and Cheung C.W.,Efficacy of pregabalin in acute postoperative pain under different surgical categories: a meta-analysis,Medicine.2015, 94(46): e1944.

Li H., Yao W., Irwin M.G., Wang T., Wang S., Zhang T. and Xia Z.,Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1,Free Radic Biol Med.2015, 84: 311-21.

Li S., Xu J., Yao W., Li H., Liu Q., Xiao F., Irwin M.G., Xia Z. and Ruan W.,Sevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathway,Biochem Biophys Res Commun.2015, 460(3): 879-86.

Liman S., Cheung C.W., Wong K., Tai W.L., Qiu Q., Ng J.K.F., Choi S.W. and Irwin M.G.,Preventive treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postichaemia pain model,Oxid Med Cell Longev.2015, 2015: 380403.

Liu B., Huang W.H., Xiao X., Yu Y., Ma S. and Xia Z.,Neuroprotective effect of ulinastatin on spinal cord ischemia-reperfusion injury in rabbits,Oxid Med Cell Longev.2015, 2015: 624819.

Liu Y., Jin J., Qiao S., Lei S., Liao S., Ge Z.D., Li H., Wong G.T.C., Irwin M.G. and Xia Z.,Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling,Clin Sci (Lond).2015, 129(4): 331-44.

Low S.J., Wong S.C.S., Qiu Q., Lee Y., Chan T.C.W., Irwin M.G. and Cheung C.W.,An audit of changes in outcomes of acute pain service: evolution over the last 2 decades,Medicine.2015, 94(40): e1673.

Luo C., Yuan D., Li X., Yao W., Luo G., Chi X., Li H., Irwin M.G., Xia Z. and Hei Z.,Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexion 32,Anesthesiology.2015, 122(1): 72-86.

Tian Y., Li H., Liu P., Xu J.M., Irwin M.G., Xia Z. and Tian G.,Captopril pretreatment produces an additive cardioprotection to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans,Mediators Inflamm.2015, 2015: 819232.

Tsui P.Y., Cheung C.W., Lee Y., Leung S.W.S. and Ng J.K.F.,The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial,BMC Anesthesiol.2015, 15: 80.

Wang D.L., Zhan L., Zhang J. and Xia Z.,Nurses’ blame attributions towards different types of cancer: a cross-sectional study,Int J Nurs Stud.2015, 52(10): 1600-6.

Wang X.M., Walitt B., Saligan L., Tiwari A.F., Cheung C.W. and Zhang Z.J.,Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy,Cytokine. 2015, 72(1): 86-96.

Xia R., Xu J., Yin H., Wu H.Z., Xia Z., Zuo D., Xia Z.Y., Zhang L.P., LI H. and Xiao X.,Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients,Mediators Inflamm.2015, 2015: 238041.

Xia Z., Chen Y., Fan Q., Xue M.Z. and Liu K.X.,Oxidative stress-mediated reperfusion injury 2014,Oxid Med Cell Longev.2015, 2015: 689416.

Yao W., Irwin M.G., Wang T., Wang S., Zhang L. and Xia Z.,Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1,Free Radic Biol Med. 84: 311-21.

Yu H.P., Chaudry I.H., Choudhry M.A., Hsing C.H., Liu F.C. and Xia Z.,Inflammatory response to traumatic injury: clinical and animal researches in inflammation,Mediators Inflamm.2015, 2015: 729637.

Zhou M., Bao Y., Li H., Pan Y., Shu L., Xia Z., Wu D., Lam K.S.L., Vanhoutte P.M., Xu A., Jia W. and Hoo R.L.C.,Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction.,Clin Sci (Lond). 2015, 129(7): 547-59.



Cheung C.W., Qiu Q., Choi S.W., Moore B.J., Goucke C.R. and Irwin M.G.,Chronic opioid therapy for chronic non-cancer pain: a review and comparison of treatment guidelines,Pain Physician. 2014, 17(5): 401-14.

Cheung C.W., Qiu Q., Ying A.C., Choi S.W., Law W.L. and Irwin M.G.,The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery,Anaesthesia. 2014, 69(11): 1214-21.

Cheung T.T., Poon R.T.P., Jenkins C.R., Chu S.K.F., Chok K.S.H., Chan A.C.Y., Tsang S.H.Y., Dai W.C., Yau T.C.C., Chan S.C., Fan S.T. and Lo C.M.,Survival analysis of high-intensity focused ultrasound therapy vs. transarterial chemoembolization for unresectable hepatocellular carcinomas,Liver Int. 2014, 34(6): e136-43.

Feng L., Liu T.T., Ye D.W., Qiu Q., Xiang H.B. and Cheung C.W.,Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: A virally mediated transsynaptic tracing study in transgenic mouse model,Epilepsy Behav. 2014, 31C: 114-6.

Greenland K.B. and Irwin M.G.,Airway management - 'spinning silk from cocoons' (-Chinese idiom),Anaesthesia.2014, 69(4): 296-00.

Hung V.K.L., Tai W.L., Qiu Q., Luo X., Wong K.L., Chung S.K. and Cheung C.W.,Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor,Mol. Cell Nurosci. 2014, 60: 26-35.

Irwin M.G. and Gan T.J.,Volume therapy with hydroxyethyl starches: are we throwing the anaesthesia baby out with the intensive care unit bathwater?Anesth. Analg. 2014, 119(3): 737-9.

Li M.J., Wang L.Y., Xia Z., Wong M.P., Sham P.C. and Wang J.W.,dbPSHP: a database of recent positive selection across human populations,Nucleic Acids Res. 2014, 42: D910-6.

Luo X., Tai W.L., Sun L.T., Qiu Q., Xia Z., Chung S.K. and Cheung C.W.,Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice,PLoS One. 2014, 9(8): e104860.

Li B.L., Yuen V.M.Y., Song X.R., Ye J., Ni J., Huang J.X. and Irwin M.G.,Intranasal dexmedetomidine following failed chloral hydrate sedation in children,Anaesthesia. 2014, 69(3): 240-4.

Li T., Li J., Li H., Xia Z., Shi X., Li X. and Liu Y.,[Effects of hypertonic sodium chloride hydroxyethyl starch solution on cerebral vasospasm following subarachnoid hemorrhage and its mechanism].,Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014, 26(8): 589-93.

Liu Y., Yang L., Tao K., Vizcaychipi M.P., Lloyd D.M., Sun X., Irwin M.G., Ma D. and Yu W.,Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release,BMC Gastroenterol. 2014, 14(1): 12.

Lu Y., Wong G.T.C., Zhang Y., Hu J. and Dong C.,Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine,Kaohsiung J Med Sci. 2014, 30(2): 68-72.

Mei W., Li M., Yu Y., Cheung C.W., Cao F., Nie B., Zhang Z., Wang P. and Tian Y.,Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study,Eur J Pain. 2014, 18(2): 238-48.

Tran H.D.D., Wong G.T.C., Chee Y.E. and Irwin M.G.,Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period,Expert Opin Biol Ther. 2014, 14(1): 51-61.

Wen S.H., Ling Y.H., Liu W.F., Qiu Y.X., Li Y.S., Wu Y., Shen J.T., Xia Z. and Liu K.X.,Role of 15-F2-isoprostane in intestinal injury induced by intestinal ischemia/reperfusion in rats,Free Radic Res. 2014, 48(8):907-18.

Wong C.F.P., Yuen V.M.Y., Wong G.T.C., To J.Y.T. and Irwin M.G.,Time to adequate oxygenation following ventilation using the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits,Paediatr Anaesth. 2014, 24(2): 208-13.

Wong K., Wu Y.R., Cheng K.S., Chan P., Cheung C.W., Lu D.Y., Su T.H., Liu Z.M. and Leung Y.M.,Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes,Pharmacol Rep. 2014, 66(6): 1106-13.

Xia Z., Chen Y., Fan Q. and Xue M.,Oxidative stress-mediated reperfusion injury: mechanism and therapies,Oxid Med Cell Longev. 2014, 2014: 373081.

Xu J., Li H., Irwin M.G., Xia Z.Y., MAO X., Lei S., Wong G.T.C., Hung V., Cheung C.W., Fang X., Clanachan A.S. and Xia Z.,Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats,Crit Care Med. 2014, 42(8): e583-94.

Yao W., Luo G., Zhu G., Chi X., Zhang A., Xia Z. and Hei Z.,Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model,Oxid Med Cell Longev. 2014, 2014: 258567.



Chan W.W., Wong G.T.C. and Irwin M.G.,Perioperative statin therapy,Expert Opin in Pharmacother. 2013, 14: 831-42.

Cheung T.T., Fan S.T., Chan S.C., Chok K.S.H., Chu S.K.F., Jenkins C.R., Lo C.L.R., Fung J.Y.Y., Chan A.C.Y., Sharr W.W., Tsang S.H.Y., Dai W.C., Poon R.T.P. and Lo C.M.,High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients,World J Gastroenterol. 2013, 19(20): 3083-9.

Cheung T.T., Fan S.T., Chu S.K.F., Jenkins C.R., Chok K.S.H., Tsang S.H.Y., Dai W.C., Chan A.C.Y., Chan S.C., Yau T.C.C., Poon R.T.P. and Lo C.M.,Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma,HPB (Oxford). 2013, 15(8): 567-73.

Cheung T.T., Poon R.T.P., Yuen W.K., Chok K.S.H., Jenkins C.R., Chan S.C., Fan S.T. and Lo C.M.,Long-term survival analysis of pure laparoscopic versus open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a single-center experience,Ann Surg. 2013, 257(3):506-11.

Chi X., Zhang A., Luo G., Xia H., Zhu G., Hei Z., Liu X., Wei J. and Xia Z.,Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model,Pulm Pharmacol Ther. 2013, 26(3):380-7.

Cho S.S., Rudloff I., Berger P.J., Irwin M.G., Nold M.F., Cheng W. and Nold-Perty C.A.,Remifentanil ameliorates intestinal ischemia-reperfusion injury,BMC Gastroenterol. 2013, 13:69.

Li H.B., Irwin M.G., Tao M., Li Y., Zhang L. and Xia Z., Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes,J Diabetes Metab. 2013, 4(3): 1000247.

Li H.B., Liu Z., Wang J.W., Wong G.T.C., Cheung C.W., Zhang L., Chen C., Xia Z. and Irwin M.G.,Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats,Cardiovasc Diabetol. 2013, 12(1):133.

Li M.J., Wang Y., Xia Z., Sham P.C. and Wang J.W.,GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications,Nucleic Acids Res. 2013, 41(WSI): W150-8.

Li L., Zhang Q.G., Lai L.Y., Wen X.J., Zheng T., Cheung C.W., Zhou S.Q. and Xu S.Y.,Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells.Oxid Med Cell Longev. 2013, 2013: 159864.

Lei S., Li H., Xu J., Liu Y., Gao X., Wang J., Ng J.K.F., Lau W.B., Ma X.L., Rodrigues B., Irwin M.G. and Xia Z.,Hyperglycemia-Induced protein kinase C beta2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling,Diabetes. 2013, 62(7): 2318-28.

Leung K.M.M. and Irwin M.G.,Perioperative cardioprotection,F1000Prime Rep. 2013, 5:7.

Liao X.L., Hu X.X., Chang F.J., Yuan F.Y., Ci H.B., Wu J.Y., Xu Z., Wang Z.P., Zhang X., Xia Z. and Ou J.S.,A simple modification results in greater success in the model of coronary artery ligation and myocardial ischemia in mice,J Cardiovasc Pharmacol. 2013, 61(5): 430-6.

Liu J., Hou J., Xia Z.Y., Zeng W., Wang X., Li R., Ke C., Xu J., Lei S. and Xia Z.,Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes,Free Radic Res. 2013, 47(5): 386-93.

Mao X., Wang T., Liu Y., Irwin M.G., Ou J., Liao X.L., Gao X., Xu Y., Ng J.K.F., Vanhoutte P.M.G.R. and Xia Z.,N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats,PLoS ONE. 2013, 8(7): e68949.

Qin J., Li M.J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.W.,ProteoMirExpress: inferring MicroRNA and Protein-centered regulatory networks from high-throughput proteomic and mRNA expression data,Mol Cell Proteomics. 2013, 12(11): 3379-87.

Tai L.W., Hung V.K., Mei W., Qiu Q., Chung S. and Cheung C.W.*,Effects of repeated central administration of endothelin type A receptor antagonist on the development of neuropathic pain in rat,BioMed Res Int. 2013, 2013: 529871.

Wang T., Yao S., Xia Z. and Irwin M.G.,Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning,Front Med. 2013, 7(3): 301-5.

Wang T., Mao X., Li H., Qiao S., Xu A., Wang J., Lei S., Liu Z., Ng K.F., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z.,N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes,Free Radic Biol Med. 2013, 63: 291-03.

Wang Y., Zhu Q., Luo C., Zhang A., Hei Z., Su G., Xia Z. and Irwin M.G.,Dual effects of bilirubin on the proliferation of rat renal NRK52E cells and ITS association with gap junctions,Dose-Response. 2013, 11(2): 220-37.

Wong G.T.C. and Irwin M.G.,Poisoning with illicit substances: toxicology for the anaesthetist,Anaesthesia. 2013, 68(S1): 117-24.

Wu H., Lei S., Yuan J., Liu X., Zhang D., Gu X., Zhang L. and Xia Z.,Ischemic postconditioning downregulates Egr-1 expression and attenuates postischemic pulmonary inflammatory cytokine release and tissue injury in rats,J Surg Res. 2013, 181(2): 204-12.

Xu J., Lei S., Liu Y., Gao X., Irwin M.G., Xia Z.Y., Hei Z., Gan X., Wang T. and Xia Z.,Antioxidant N-acetylcysteine attenuates the reduction of brg1 protein expression in the myocardium of type 1 diabetic rats,J Diabetes Res. 2013, 2013: 716219.

Ye D.W., Ding D.F., Liu T.T., Tian X.B., Liu C., Li R.C., Xiang H.B. and Cheung C.W.,The optimal segment for spinal cord stimulation in intractable epilepsy: A virally mediated transsynaptic tracing study in spinally transected transgenic mice,Epilepsy Behav. 2013, 29(3): 599-01.


Alaali H.H. and Irwin M.G., Anaesthesia for urologial surgery,Anaesth Intensive Care Med. 2012, 13 (7): 343-7.

Cheung C.W., Choi W.W.S., Leung M.Y.Y., Lui F., Ng J.K.F., Ho A.M.H. and Irwin M.G.,A double blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia,J Oral Maxillofac Surg. 2012, 70(1): 25-30.

Cheung J.P.Y., Ng J.L.M., Chow W. and To M.K.T.,Fat embolism syndrome in a child with dystonia musculorum deformans,BMJ Case Rep. 2012, doi: 10.1136/bcr.12.2011.5466.

Cheung T.T., Chu F.S., Jenkins C.R., Tsang D.S., Chok K.S.H., Chan A.C.Y., Yau T.C.C., Chan S.C., Poon R.T.P., Lo C.M. and Fan S.T.,Tolerance of high-intensity focused ultrasound ablation in patients with hepatocellular carcinoma,World J Surg. 2012, 36(10): 2420-7.

Gao X., Xu Y., Xu B., Liu Y., Cai J., Liu H.M., Lei S., Zhong Y.Q., Irwin M.G. and Xia Z.,Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes,Diabetes Metab Res Rev. 2012, 28(5): 409-17.

Ho A.M.H., Dion P.W., Yeung J.H.H., Joynt G.M., Lee A., Ng C.S.H., Chang A., So F.L. and Cheung C.W.,Simulation of survivorship bias in observational studies on plasma to red blood cells ratios in massive transfusion in trauma,Br J Surg. 2012, 99(S1): 132-9.

Ho A.M.H., Dion P.W., Yeung J.H.H., Holcomb J.B., Critchley L.A.H., Ng C.S.H., Karmakar M.K., Cheung C.W. and Rainer T.H.,Prevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusion,Anesthesiology. 2012, 116(3): 716-28.

Ho A.M., Ricci C.J., Ng C.S., Critchley L.A., Ho A.K., Karmakar M.K., Cheung C.W. and Ng S.K.,The medial-transverse approach for internal jugular vein cannulation: an example of lateral thinking,J Emerg Med. 2012, 42(2): 174-7.

Huang P., Liu D., Gan X., Zhang R., Gao W., Xia Z. and Hei Z.,Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats,Injury. 2012, 43(8): 1250-6.

Hung K.L., Chan M.M., Chen A.Y.S., Tai L.W., Chung S.K. and Cheung C.W.,Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection,Life Sci. 2012, 91(13-14): 618-22.

Irwin M.G. and Wong S.S.C., Anaesthesia and minimally invasive surgery,Anaesth Int Care Med. 2012, 13(2): 48-51.

Irwin M.G. and Wong S.S.C., Anaesthesia for fractured neck of femur,Anaesth Int Care Med. 2012, 13(3): 94-8.

Lei S., Liu Y., Liu H., Yu H., Wang H. and Xia Z.,Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats,Yonsei Med J. 2012, 53(2): 294-303.

Li T., Wu W., You Z., Zhou R., Li Q., Zhu D., Li H., Xiang X., Irwin M.G. and Xia Z.,Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass,Eur J Pharmacol. 2012, 677(1-3): 138-46.

Liu K.X. and Xia Z.,Potential synergy of antioxidant N-acetylcysteine and insulin in restoring sevoflurane postconditioning cardioprotection in diabetes,Anesthesiology. 2012, 116(2):488-9.

Liu Y, Lei S, Gao X, Mao X, Wang T, Wong GT, Vanhoutte PM, Irwin MG, Xia Z.PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes,Clin Sci (Lond). 2012, 122(4):161-73.

Lu D.Y., Chang C.S., Yeh W.L., Tang C.H., Cheung C.W., Leung Y.M., Liu J.F. and Wong K.L.,The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways,Phytomedicine. 2012, 19(12): 1093-100.

Ng F.Y., Ng J.K.F., Chiu P.K.Y., Yan C.H. and Chan C.W.,Multimodal periarticular injection vs continuous femoral nerve block after total knee arthroplasty: a prospective, crossover, randomized clinical trial,J Arthroplasty. 2012, 27(6): 1234-8.

Poon T.C.J., Cheung C.W., Fan J.K.M., Lo O.S.H. and Law W.L.,Single-incision versus conventional laparoscopic colectomy for colonic neosplasm: arandomized,controlled trial,Surg Endosc. 2012, 26(10): 2729-34.

Sharma A., Lawmin J. and Irwin M.G., Anaesthesia for spinal surgery,Anaesth Int Care Med. 2012, 13(3): 99-101.

Wang Y., Wong G.T.C., Man K., Irwin M.G.,Pretreatment with intrathecal or intravenous morphine attenuates hepatic ischaemia-reperfusion injury in normal and cirrhotic rat liver,Br J Anaesth. 2012, 109(4): 529-39.

Wong G.T.C. and Irwin M.G.,EVAR fever: minimally invasive, maximally inclusive?Anaesthesia.2012, 67(4): 351-4.

Wong G.T.C., Lu Y., Mei B., Xia Z. and Irwin M.G.,Cardioprotection from remote preconditioning involves spinal opioid receptor activation,Life Sci. 2012, 91(17-18): 860-5.

Wong G.T.C., Lu Y, Xia Z, Irwin M.G.,Intrathecal morphine remotely preconditions the heart via a neural pathway,J Cardiovasc Pharmacol. 2012, 60(2): 172-8.

Wong S. and Irwin M.G., Procedures under tourniquet,Anaesth Int Care Med. 2012, 13(3): 85-8.

Wylie S.J., Wong G.T.C., Chan Y.C. and Irwin M.G.,Endovascular aneurysm repair: a perioperative perspective,Acta Anaesthesiol Scand. 2012, 56(8): 941-9.

Yuen V.M.Y., Hui T.W.C., Irwin M.G., Yao T.J., Chan L., Wong G.L., Shahnaz Hasan M. and Shariffuddin I.I.,A randomised comparison of two intranasal dexmedetomidine doses for premedication in children,Anaesthesia. 2012, 67(11): 1210-6.

Zhang Y.M., Wang C.Y., Zheng F.C., Gao F.F., Chen Y.C., Huang Z.Q., Xia Z., Irwin M.G., Li W.Q., Liu X.P., Zheng Y.S., Xu H. and Shi G.G.,Effects of N-n-butyl haloperidol iodide on the rat myocardial sarcoplasmic reticulum Ca(2+)-ATPase during ischemia/reperfusion,Biochem Biophys Res Commun. 2012, 425(2): 426-30.



Chan B.K.B., Tam L.K., Chung Y.F., Wat C.Y., Tsui S.L. and Cheung C.W.,Opioids in Chronic non-cancer pain,Expert Opin Pharmacother. 2011, 12(5): 705-20.

Chan S.C., Lo C.M., Ng K.K.C., Ng I.O.L., Yong B.H. and Fan S.T.,Portal inflow and pressure changes in right liver living donor liver transplantation including the middle hepatic vein,Liver Transpl. 2011, 17(2): 115-21.
Cheung C.W., Ng J.K.F., Liu J., Yuen V.M.Y., Ho M.H.A. and Irwin M.G.,Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia,Br J Anaesth. 2011, 107(3):430-7.
Cheung C.W., Ng J.K.F., Choi W.W.S., Chiu W.K., Ying C.L.A. and Irwin M.G.,Evaluation of the analgesic efficacy of local dexmedetomidine application,Clin J Pain. 2011, 27(5): 377-82.
Chou C.W., Wong G.T.C., Lim G., McCabe M.F., Wang S., Irwin M.G. and Mao J., Peripheral nerve injury alters the expression of NF-κB in the rat's hippocampus,Brain Res. 2011, 1378: 66-71.
Chou C.W., Wong G.T.C., Lim G., Wang S., Irwin M.G. and Mao J.,Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury,J Pain. 2011, 12(1): 13-21.
Fan Q., Yang X.C., Liu Y., Wang L.F., Liu S.H., Ge Y.G., Chen M.L., Wang W., Zhang L.K., Irwin M.G. and Xia Z.,Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans,Clin Sci (Lond). 2011, 120(6): 251-61.
Huang S.M., Cheung C.W., Chang C.S., Tang C.H., Liu J.F., Lin Y.H., Chen J.H., Ko S.H., Wong K. and Lu D.Y.,Phloroglucional derivative MCPP induces cell apoptosis in human colon cancer,J Cell Biochem. 2011, 112(2): 643-52.
Huang Z., Zhong X.W., Irwin M.G., Ji S., Liu Y., Xia Z.Y.,Finegan B.A. and Xia Z., Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients,Clin Sci (Lond). 2011, 121(2): 57-69.
Hung I.F.N., To K.K.W., Lee C.K., Lee K.L., Chan K., Yan W.W., Liu R., Watt C.L., Chan W.M., Lai K.Y., Koo C.K., Buckley T., Chow F.L., Wong K.K., Chan H.S., Ching C.K.,
Tang B.S.F., Lau C.Y., Li W.S., Liu S.H., Chan K.H., Lin C.K. and Yuen K.Y.,Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection,Clin Infect Dis. 2011, 52(4): 447-56.
Liu H.M., Liu K.X., Cheng M.H., Liu Y., Lei S., Irwin M.G. and Xia Z.,Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts,J Surg Res. 2011, 168(1): 18-26.
Lu Y., Wong G.T.C., Xia Z. and Irwin M.G.,Interaction between spinal opioid and adenosine receptors in the remote cardiac preconditioning effect of intrathecal morphine,J Cardiothorac Vasc Anesth. 2011, 25(3):444-8.
Lui F. and Ng J.K.F.,Adjuvant analgesics in acute pain,Expert Opin Pharmacother. 2011, 12(3): 363-85.
Ng J.K.F., Cheung C.W. and Lee Y.,Low dose desmopressin improves hypothermia induced impairment of primary haemostasis in healthy volunteers,Anaesthesia. 2011, 66(11):999-1005.
Tse E.Y.W., Cheung W.Y., Ng J.K.F. and Luk K.D.K.,Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery,J Bone Joint Surg Am. 2011, 93(13): 1268-77.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Xu A., Lam K.S.L., Irwin M.G. and Xia Z.,N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats,PLoS One. 2011, 6(8):e23967.
Wei L., Le X.C., Xia Z., Han Y. and Rong J., Pharmacological induction of leukotriene B4 12-hydroxydehydrogenase in human neutrophils and its potential in the treatment of myocardial injury, Journal of Heart Disease,Cardiology Online. 2011, 8: 66.
Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R.,Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain,J Mol Cell Cardiol. 2011, 51(6): 966-73.
Xia Z. and Vanhoutte P.M.G.R.,Nitric oxide and protection against cardiac ischemia,Curr Pharm Des. 2011, 17(18): 1774-82.
Xu B., Gao X., Xu J., Lei S., Xia Z.Y., Xu Y. and Xia Z.,Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1,J Surg Res. 2011, 166(2): e157-64.
Yang L.Q., Tao K.M., Liu Y.T., Cheung C.W., Wong G.T.C., Lv H., Song J.G., Wu F.X. and Yu W.F.,Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression,Anesthesiology. 2011, 114(5): 1036-47.
Zhang Y., Lu Y., Mei B., Zhou Y.M., Chen Z.W. and Wong T.M.,Intracerebroventricular administration of morphone confers remote cardioprotecion - role of opioid receptors and calmodulin,Eur J Pharmacol. 2011, 656(1-3):74-80.
Zhu X.H., Yuan H.J., Wu Y.N., Kang Y., Jiao J.J., Gao W.Z., Liu Y.X., Lou J.S. and Xia Z.,Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats,Free Radic Res. 2011, 45(2): 201-10.


Chan S.C., Lo C.M., Yong B.H., Tsui W.J.C., Ng K.K.C. and Fan S.T., Paired donor interchange to avoid ABO-incompatible living donor liver transplantation,Liver Transpl. 2010, 16(4): 478-81.

Cheng T.H., Leung Y.M., Cheung C.W., Chen C.H., Chen Y.L. and Wong K.L., Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts,Anesthesiology. 2010, 112(1): 108-18.
Chiang J.C.S., Irwin M.G., Hussain A., Tang Y.K. and Hiong Y.T., Anaesthesia for emergency caesarean section in a patient with large anterior mediastinal tumour presenting as intrathoracic airway compression and superior vena cava obstruction,Case Report Med. 2010, 2010:708481.
Greenland K.B., Edwards M.J., Hutton N.J., Challis V.J., Irwin M.G. and Sleigh J.W.,Changes in airway configuration with different head and neck positions using magnetic resonance imaging of normal airways: a new concept with possible clinical applications,Br J Anaesth. 2010, 105(5): 683-90.
Guo Y., Wu X.Q., Zhang C., Liao Z.X., Wu Y., Xia Z. and Wang H.,Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices,Clin Exp Pharmacol Physiol. 2010, 37(12): 1107-13.
Ho A.M.H., Dion P.W., Yeung Y.H.H., Ng C.S.H., Karmakar M.K., Crtichley L.A.H., Rainer T.R., Cheung C.W. and Tay B.A.,Fresh-frozen plasma transfusion strategy in trauma with massive and ongoing bleeding. Common (sense) and sensibility,Resuscitation. 2010, 81(9): 1079-81.
Jiang L., Wong G.T.C., Lu Y., Xia Z. and Irwin M.G.,Remote pharmacological post-conditioning by intrathecal morphine: cardiac protection from spinal opioid receptor activation,Acta Anaesthesiol Scand. 2010, 54(9): 1097-04.
Lau T.W., Leung F.K.L., Siu D.C.W., Wong G.T.C. and Luk K.D.K.,Geriatric hip fracture clinical pathway: the Hong Kong experience,Osteoporosis Int. 2010, 21(S4): S627-36.
Li Y.S., Wang Z.X., Li C., Xu M., Li Y., Huang W.Q., Xia Z. and Liu K.X.,Proteomics of ischemia/reperfusion injury in rat intestine with and without ischemic postconditioning,J Surg Res. 2010, 164(1):e173-80.
Liang S. and Irwin M.G., Review of anesthesia for middle ear surgery,Anesthesiol Clin. 2010, 28(3): 519-28.
Liu K.X., Li C., Li Y.S., Yuan B.L., Xu M., Xia Z. and Huang W.Q.,Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase,Proteomics. 2010, 10(24):4463-75.
Lu D.Y., Leung Y.M., Cheung C.W., Chen Y.R. and Wong K.,Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells,Biochem Pharm. 2010, 80(8):1201-9.
Chan A.K., Cheung C.W. and Chong Y.K.,Alpha-2 agonists in acute pain management,Expert Opin Pharmacother. 2010, 11(17):2849-68.
Poon J.T.C., Cheng S.W.K., Wong S.J. and Ting A.C.W.,Prevalence of abdominal aortic aneurysm in Chinese patients with severe coronary artery disease,ANZ J Surg. 2010, 80(9):630-3.
Siu D.C.W., Sun N.C.H., Lau T.W., Yiu K.H., Leung F.K.L. and Tse H.F.,Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective.Osteoporos Int. 2010, 21(S4):S587-91.
Tan G. and Irwin M.G.,Recent advances in using propofol by non-anesthesiologists,F1000 Med Rep. 2010, 2:79.
Wang M., Peng J., Wang R., Zhao L. and Xia Z.,TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits,J Surg Res. 2010 Sept In press.
Wong E.S.W., Man R.Y.K., Vanhoutte P.M. and Ng K.F.J.,Dexmedetomidine induces both relaxations and contractions, via different α2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat,J Pharmacol Exp Ther.2010, 335(3): 659-64
Wong G.T.C. and Irwin M.G.,Pretreatment time with norbinaltorphimine [Letter],Anesth Analg. 2010, 110(4): 1243-4.
Wong G.T.C. and Sun N.C.H.,Providing perioperative care for patients with hip fractures,Osteoporos Int. 2010, 21(S4): S547-53.
Wong G.T.C., Jiang L.L. and Irwin M.G.,Activation of central opioid receptors induces cardioprotection against ischemia-reperfusion injury,Anesth Analg. 2010, 111(1): 24-8.
Wong G.T.C., Li R., Jiang L. and Irwin M.G.,Remifentanil post-conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation,Acta Anaesthesiol Scand. 2010, 54(4): 510-8.
Wong G.T.C., Huang Z., Ji S. and Irwin M.G.,Remifentanil reduces the release of biochemical markers of myocardial damage after coronary artery bypass surgery: a randomized trial,J Cardiothorac Vasc Anesth. 2010, 24(5): 790-6.
Xia Z., Luo T., Liu H., Wang F., Xia Z.Y., Irwin M.G. and Vanhoutte P.M.G.R.,L-arginine enchances nitrative stress and exacerbates tumor necrosis factor-α toxicity to human endothelial cells in culture: prevention by propofol,J Cardiovasc Pharmacol. 2010, 55(4): 358-67.
Yang L.Q., Tao K.M., Cheung C.W., Liu Y.T., Tao Y., Wu F.X. and Yu W.F.,The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients,Anaesthesia. 2010, 65(11): 1094-00.
Yang L.Q., Song J.C., Irwin M.G., Song J.G., Sun Y.M. and Yu W.F.,A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice,Acta Aaesthesiol Scand. 2010, 54(7): 871-7.
Yuen V.M.Y., Hui T.W.C., Irwin M.G., Yao T.J., Wong G.L.S. and Yuen M.K.,Optimal timing for the administration of intranasal dexmedetomidine for premedication in children,Anaesthesia. 2010, 65(9):922-9.
Zhang J.F., Yang J.P., Wang G.H., Xia Z., Duan S.Z. and Wu Y.,Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion,Diabetes Metab Res Rev. 2010, 26(1): 59-70.


Chan A.C., Fan S.T., Lo C.M., Liu C.L., Chan S.C., Ng K.K., Yong B.H., Chiu A. and Lam B.K.,Liver transplantation for acute-on-chronic liver failure,Hepatol Int. 2009, 3(4): 571-81.
Cheung C.W., Ying C.L., Lee L.H., Tsang S.F., Tsui S.L. and Irwin M.G.,An audit of postoperative intravenous patient-controlled analgesia with morphine: evolution over the last decade,Eur J Pain. 2009, 13(5): 464-71.
Choi W.S., Irwin M.G. and Samman N.,The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial,J Oral Maxillofac Surg. 2009, 67(1): 125-33.
Chung P.H.Y., Wong K.K.Y., Tam P.K.H., Chan K.L., Ng K.K.C., Chan S.C., Hui T.W.C., Yong B.H., Fan S.T. and Lo C.M.,Split graft liver transplant for paediatric patients in Hong Kong,HK J Paediatr (new series). 2009, 14(3): 181-5.
Irwin M.G., Trinh T.P. and Yao C.L.,Occupational exposure to anaesthetic gases: a role for TIVA,Expert Opin Drug Saf. 2009, 8(4): 473-83.
Kong V.K.F. and Irwin M.G.,Adjuvant analgesics in neuropathic pain,Eur J Anaesthesiol. 2009, 26(2): 96-100.
Li R., Wong G.T.C., Wong T.M., Zhang Y., Xia Z. and Irwin M.G.,Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa and mu opioid receptors in rats,Anesth Analg. 2009, 108(1): 23-9.
Liu K.X., Li Y.S., Huang W.Q., Chen S.Q., Wang Z.X., Liu J.X. and Xia Z.,Immediate postconditioning during reperfusion attenuates intestinal injury,Intensive Care Med. 2009, 35(5): 933-42.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y.,The value of a single preoperative PFA-100® measurement in assessing the risk of bleeding in patients taking cyclooxygenase inhibitors and undergoing total knee replacement,Br J Anaesth. 2009, 102(6): 779-84.
Poon C.C. and Irwin M.G.,Anaesthesia for deep brain stimulation and in patients with implanted neurostimulator devices,Br J Anaesth. 2009, 103(2): 152-65.
Tam L.K. and Ng J.K.F.,The role of desmopressin in a patient with severe coagulopathy aggravated by mild therapeutic hypothermia [letter],Resuscitation. 2009, 80(10): 1216-7.
Tam M.K., Irwin M.G., Tse M.L., Lui Y.W., Law K.I. and Ng P.W.,Prolonged myoclonus after a single bolus dose of propofol,Anaesthesia. 2009, 64(11): 1254-7.
Tsai G.Y., Cui J.Z., Syed H., Xia Z., Ozerdem U., McNeill J.H. and Matsubara J.A.,Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats,Clin Experiment Ophthalmol. 2009, 37(2): 223-31.
Wang F., Liu H.M., Irwin M.G., Xia Z.Y., Huang Z., Ouyang J. and Xia Z.,Role of protein kinase C β2 activation in TNF-α-induced human vascular endothelial cell apoptosis,Can J Physiol Pharmacol. 2009, 87(3): 221-9.
Xia Z. and Irwin M.G.,Esmolol may abolish volatile anesthetic-induced postconditioning by scavenging reactive oxygen species,Anesthesiology. 2009, 111(4): 924-5.
Zhang Y., Irwin M.G., Li R., Chen Z.W. and Wong T.M.,Effects of remifentanil on intracellular Ca2+ and its transients induced by electrical stimulation and caffeine in rat ventricuar myocytes,Chinese Med J. 2009, 122(12): 1439-43.


Chan Y.C., Cheng S.W.K. and Irwin M.G., Perioperative use of statins in noncardiac surgery,Vasc Health Risk Manag. 2008, 4(1): 75-81.

Cheung C.W., Irwin M.G., Chiu W.K. and Ying C.L.A., A study to assess the value of bispectral analysis in intravenous sedation with midazolam during third molar surgery under local anaesthesia,Anaesthesia. 2008, 63(12): 1302-8.

Chia A.C., Irwin M.G., Lee P.W., Lee T.H. and Man S.F., Comparison of stress in anaesthetic trainees between Hong Kong and Victoria,Anaesth Intensive Care. 2008, 36(6): 855-62.

Fung N.Y., Hu Y., Irwin M.G., Chow B.E. and Yuen V.M.Y., Comparison between sevoflurane/remifentanil and propofol/remifentanil anaesthesia in providing conditions for somatosensory evoked potential monitoring during scoliosis corrective surgery,Anaesth Intensive Care. 2008, 36(3): 779-85.

Greenland K.B., Eley V., Edwards M.J., Allen P. and Irwin M.G., The origins of sniffing position and the Three Axes Alignment Theory for direct laryngoscopy,Anaesth Intensive Care. 2008, 36(S1): 23-7.

Ho E.Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature,FASEB Journal. 2008, 22: 914.10.

Lee L.H.Y., Irwin M.G., Yao T.J., Yuen M.K. and Cheung C.W., Timing of intraoperative parecoxib analgesia in colorectal surgery,Acute Pain. 2008, 10(3-4): 123-30.

Liu K.X., Huang W.Q., Li Y.S., Irwin M.G. and Xia Z., Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats,Anesth Analg. 2008, 107(6): 1884-91.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M., C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary artery,FASEB J. 2008, 22: 914.3.

Ng J.K.F., Tsang S.F., Leung S.W.S., Tang W.M. and Chiu P.K.Y., Coagulation, blood loss and platelet activation during isoflurane or sevolfurane anaesthesia,Anesthesiology. 2008, 109: A1619.

Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac.,J Arthroplasty. 2008, 23(3): 424-30.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M., Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins,Acta Pharmacol Sin. 2008, 29(12): 1419-24.

Ng W.W.H., Keung W.W.Y., Xu Y.C., Ng J.K.F., Leung G.P.H., Vanhoutte P.M., Choy P.C. and Man R.Y.K., Genistein potentiates protein kinase A activity in porcine coronary artery,Mol Cell Biochem. 2008, 311(1-2): 37-44.

Nie R., Zhong X. and Xia Z., Antioxidant intervention before and during myocardial ischemia may exacerbate post-ischemic myocardial dysfunction: relationship with endothelin-1 production,Med Hypotheses. 2008, 70(1): 194-5.

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation,Liver Transpl. 2008, 14(7): 1038-43.

Xia Z., Role of hydrogen peroxide in propofol restoration of microvacular function impaired by high glucose,Anesthesiology. 2008, 109(5): 930.

Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G., Anaesthesia for high intensity focused ultrasound (HIFU) therapy,Anaesthesia. 2008, 63(8): 865-72.

Ying C.L.A., Tsang S.F. and Ng J.K.F., The potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100?,Resuscitation. 2008, 76(1): 129-33.

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial,Anesth Analg. 2008, 106(6): 1715-21.

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C., Ng J.K.F. and Irwin M.G.,A comparison of dexmedetomidine and midazolam for sedation in third molar surgery,Anaesthesia. 2007, 62(11): 1132-8.

DiemunschP., Gan T.J., Philip B.K., Girao M.J., Eberhart L., Irwin M.G., Pueyo J. and Lawson F.C.,Single-dose aprepitant versus ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery,Br J Anaesth. 2007, 99(2): 202-11.

Greenland K.B., Liu G., Tan H., Edwards M. and Irwin M.G., Comparison of the Levitan FPS ScopeTMand the single-use bougie for simulated difficult intubation in anaesthetised patients,Anaesthesia. 2007, 62(5): 509-15.

Greenland K.B., Tsui D., Goodyear P. and Irwin M.G., Personal protection equipment for biological hazards: does it affect tracheal intubation performance?Resuscitation. 2007, 74(1): 119-26.

GuoC.X.X., Irwin M.G., Cheung K.M.C. and Chan D., An effective dose of Valdecoxib in experimental mouse models of pain,Methods Find Exp Clin Pharmacol. 2007, 29(6): 383-8.

Kong V.K.F. and Irwin M.G., Gabapentin: a multimodal perioperative drug?Br J Anaesth. 2007, 99(6): 775-86.

Kong V.K.F., Yuen M.K. and Irwin M.G., Perioperative ultrasonography: ultrasound and vascular cannulation,CPD Anaesthesia. 2007, 9(1): 3-9.

Yu C.K., Li Y.H., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat,Br J Anaesth. 2007, 99(5): 632-8.

NieR., Xia R., Zhong X. and Xia Z., Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat,Can J Physiol Pharmacol. 2007, 85(10):1012-9.

Wong G.T.C., Jenkins C.R., Yao T.J. and Irwin M.G., A trend toward improved learning of cardiovascular pathophysiology in medical students from using a human patient simulator: results of a pilot study,Advan in Physiol Edu. 2007, 31(4): 372.

Wong G.T.C. and Irwin M.G., Contrast-induced nephropathy,Br J Anaesth. 2007, 99(4): 474-83.

Wong G.T.C., Yuen V.M.Y., Chow B.F.M. and Irwin M.G., Persistent pain in patients following scoliosis surgery,Eur Spine J. 2007, 16(10): 1551-6.

Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double-blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine,Anesth Analg. 2007, 105(2): 374-80.

Caves N.D. and Irwin M.G., Attitudes to basic life support among medical students following the 2003 SARS outbreak in Hong Kong,Resuscitation. 2006, 68(1): 93-100.

CheungR.W., Irwin M.G., Law B.C.W. and Chan C.K., A clinical comparison of the FlexibladeTMand Macintosh laryngoscopes for laryngeal exposure in anesthetized adults,Anesth Analg. 2006, 102(2): 626-30.

Fielding R. and Irwin M.G., The knowledge and perceptions of nurses and interns regarding acute pain and postoperative pain control (Research dissemination report – nursing studies),Hong Kong Med J. 2006, 12(2-S1): 31-4.

Greenland K.B., Ha I.D. and Irwin M.G., Comparison of the Berman intubating airway and the Williams airway intubator for fibreoptic orotracheal intubation in anaesthetised patients,Anaesthesia. 2006, 61(7): 678-84.

Irwin M.G., "NSAIDs - can't live with them… can't live without them",European Society of Anaesthesiology Newsletter. 2006, 26(Spring):10-11.

KanA.S.Y., Caves N.D., Wong S.Y.W., Ng E.H.Y. and Ho P.C.,A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination,Hum Reprod. 2006, 21(10): 2606-11.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center,Ann Surg. 2006, 243(3): 404-10.

Ng J.K.F., Yuen T.S.T. and Ng V.M.W., A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia,J Clin Anesth. 2006, 18(3): 205-10.

Wong A.Y.C., O'Regan A.M. and Irwin M.G., Total intravenous anaesthesia with propofol and remifentanil for elective neurosurgical procedures: an audit of early postoperative complications,Eur J Anaethesiol. 2006, 23(7): 586-90.

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anaesthesia: a double-blinded randomized controlled trial,Anesth Analg. 2006, 106(6): 1715-21.