Chan TCW, Wong JSH, Wang FF, Fang CX, Yung CS, Chan MTK, Chan WSH, Wong SSC. Addition of liposomal bupivacaine to standard bupivacaine versus standard bupivacaine alone in the supraclavicular brachial plexus block: a randomized controlled trial.  Anesthesiology 2024; Online ahead of print.

Chen YL, Feng X, Tam K, Fan C, Cheung MP, Yang Y, Wong SSC, et al. Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury.  NPJ Regen Med 2024; 9(1): 13.

Cheung ACK, NG PY, Lam RPK, Wong GTC. Cross-specialty point-of-care ultrasound education in The University of Hong Kong.  Hong Kong Med J 2024; 30(3): 255.

Chen Y, Chu JM, Wong GT, Chang RC. Complement C3 from astrocytes plays significant roles in sustained activation of microglia and cognitive dysfunctions triggered by systemic inflammation after laparotomy in adult male mice.  J Neuroimmune Pharmacol 2024; 19(1): 8.

Liu Z, Shan Z, Yang H, Xing Y, Guo W, Cheng J, et al.   Quercetin, main active ingredient of moutan cortex, alleviates chronic orofacial pain via block of voltage-gated sodium channel.  Anesth Analg 2024; 138(6): 1324-36.

Murphy T, Stewart P, Nestor CC, Irwin MG. Handling injectable medications: mixing drugs.  Anaesthesia 2024; 79(4): 436-7.

Tsui FPY, Wong SSC, Chan TCW, Lee Y, Cheung CW.  A validation study of the Cantonese Chinese version of short form McGill pain questionnaire 2 in Cantonese-speaking patients with chronic pain in Hong Kong.  Pain Pract 2024; 24(3): 449-57.

Wu FHW, Cheung CW, Leung YY . Neuronavigation-guided percutaneous rhizotomies to trigeminal neuralgia: a systematic review.  Clin J Pain 2024; 40(4): 253-66.

Xia M, Jin C, Zheng Y, Wang J, Zhao M, Cao S, et al. Deep learning-based facial analysis for predicting difficult videolaryngoscopy: a feasibility study.  Anaesthesia 2024; 79(4): 399-409.

Yu J, Wong S, Lin Z, Shan Z, Fan C, Xia Z, et al. High-frequency spinal stimulation suppresses microglial Kaiso-P2X7 receptor axis-induced inflammation to alleviate neuropathic pain in rats.  Ann Neurol 2024; 95(5): 966-83.


Chan MTV, Lam CKM, Cheng BCP, Gin T, Cheung CW.  Perioperative hypothermia and myocardial injury after non-cardiac surgery: abridged secondary publication.  Hong Kong Med J 2023; 29 Suppl 4(4): 36-8.

Chan PK, Chan TCW, Mak CYH, Chan THM, Chan SHW, Wong SSC, et al. Pain relief after total knee arthroplasty with intravenous and periarticular corticosteroid: a randomized controlled trial. J Bone Joint Surg Am 2023; 105(12): 924-32.

Chen Y, Joo J, Chu JM, Chang RC, Wong GT.  Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice.  J Neuroinflammation 2023; 20(1): 237.

Cheung BHH, Lau GKK, Wong GTC, Lee EYP, Kulkarni D, Seow CS, et al. ChatGPT versus human in generating medical graduate exam multiple choice questions-A multinational prospective study (Hong Kong S.A.R., Singapore, Ireland, and the United Kingdom). PLoS One 2023; 18(8): e0290691.

Curtin J, Thomson P, Wong G, Lam A, Choi SW. The impact of surgery on circulating malignant tumour cells in oral squamous cell carcinoma. Cancers (Basel) 2023; 15(3): 584.

Deng W, Nestor CC, Leung KMM, Chew J, Wang H, Wang S, Irwin MG.   Aerosol generation with the use of positive pressure ventilation via supraglottic airway devices: an observational study.  Anaesthesia 2023; 78(9): 1112-9.

Fan T, Yu Y, Chen Y, Gu P, Wong SCS, Xia ZY, Liu JA, Cheung CW. Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy.  Glia 2023; 71(4): 1099-119.

Ho HC, Song Y, Cheng W, Liu Y, Guo Y, Lu S, et al.   How do forms and characteristics of Asian public housing neighbourhoods affect dementia risk among senior population? A cross-sectional study in Hong Kong.   Public Health  2023; 219: 44-52.

Ho HC, Wong SCS, Cheung CW. Individual-level and neighborhood-level shifts in mortality patterns among drug poisoning deaths in a high-density Asian city: a territory-wide, case-only analysis. Int Health 2023; 15(6): 715-22.

Huang J, Cui Y, Li L, Guo M, Ho HC, Lu Y, Webster CJ. Re-examining Jane Jacobs’ doctrine using new urban data in Hong Kong. EPB: Urban Analytics and City Science 2023; 50(1): 76-93.

Hughes LM, Irwin MG, Nestor CC. Alternatives to remifentanil for the analgesic component of total intravenous anaesthesia: a narrative review. Anaesthesia 2023; 78(5): 620-5.

Hughes LM, Power S, Irwin MG, Nestor CC.   Sedatives and Postoperative Delirium: Comment.  Anesthesiology 2023; 139(5): 709.

Irwin MG, Wong MCS.  Perspective: a new article type for the Hong Kong Medical Journal. Hong Kong Med J 2023; 29(1): 15.

Lai PBS, Wong GTC, Wong SYS. 'Ten Years Down the Line': a roundtable on the progress and advancement of medical education and training. Hong Kong Med J 2023; 29(3): 195-7.

Leung SYD, Meng F, Liu J, Liu AJ, Ng HLL, Cheung CW, Wong SCS. Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling. Mol Pain 2023; 19: 17448069231185232.

Li F, Liu W, Hu C, Tang M, Zhang Y, Ho HC, et al Global association of greenness exposure with risk of nervous system disease: A systematic review and meta-analysis.  Sci Total Environ 2023; 877: 162773.

Li T, Wei Z, Jin F, Yuan Y, Zheng W, Qian L, et al. Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation telesimulation.  Nat Commun 2023; 14(1): 8386.

Li W, Liu C, Ho HC, Shi L, Zeng Y, Yang X, Huang Q, Pei Y, Huang C, Yang L.   Association between antibiotic resistance and increasing ambient temperature in China: An ecological study with nationwide panel data. Lancet Reg Health West Pac 2023; 30: 100628.

Li W, Liu C, Ho HC, Shi L, Zeng Y, Yang X, Xia H, et al Estimating the effect of increasing ambient temperature on antimicrobial resistance in China: A nationwide ecological study with the difference-in-differences approach.  Sci Total Environ 2023; 882: 163518.

Liu JA, Tam KW, Chen YL, Feng X, Chan CWL, Lo ALH, et al  Transplanting human neural stem cells with ≈50% reduction of SOX9 gene dosage promotes tissue repair and functional recovery from severe spinal cord injury.  Adv Sci (Weinh) 2023; 10(20): e2205804.

Liu JA, Wong SCS. Molecular mechanisms and pathophysiological pathways of high-fat diets and caloric restriction dietary patterns on pain. Anesth Analg 2023; 137(1): 137-52.

Tao J, Zheng H, Ho C, Wang X, Hossain MZ, Bai Z, Wang N, Su H, Xu Z, Cheng J. Urban-rural disparity in heatwave effects on diabetes mortality in eastern China: A case-crossover analysis in 2016–2019.  Sci Total Enviro 2023; 858(Pt2): 160026.

Wang F, Cheung CW, Wong SCS. Regenerative medicine for the treatment of chronic low back pain: A narrative review. J Int Med Res 2023; 51(2): 3000605231155777.

Wang F, Cheung CW, Wong SSC. Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia. Front Genet 2023; 14: 1026672.

Wong ASK, Marwali EM, Maclaren G, Ogino M, Fraser J, Lai CKP, Fitria L, Adriane P, Sin SWC. ECMO simulation training during a worldwide pandemic: the role of ECMO telesimulation. Perfusion 2023; 38(5): 1029-36.

Wong CH, Chan TCW, Wong SCS, Russo M, Cheung CW. Efficacy of peripheral nerve field stimulation for the management of chronic low back pain and persistent spinal pain syndrome: a narrative review.  Neuromodulation 2023; 26(3): 538-51.

Wong SSC, Chan TH, Wang F, Chan TCW, Ho HC, Cheung CW. Analgesic effect of buprenorphine for chronic noncancer pain: a systematic review and meta-analysis of randomized controlled trials. Anesth Analg 2023; 137(1): 59-71.

Wong SSC, Wang F, Chan TCW, Cheung CW. The analgesic effect of total intravenous anaesthesia with propofol versus inhalational anaesthesia for acute postoperative pain after hepatectomy: a randomized controlled trial. BMC Anesthesiol 2023; 23(1): 112.

Wu Q, Yang M, Wu K, Su H, Huang C, Xu Z, et al Abnormal ambient temperature change increases the risk of out-of-hospital cardiac arrest: A systematic review and meta-analysis of exposure types, risk, and vulnerable populations. Sci Total Environ 2023; 861: 160554.

Xia M, Ma W, Zuo M, Deng X, Xue F, Battaglini D,et al. Expert consensus on difficult airway assessment.  Hepatobiliary Surg Nutr 2023; 12(4): 545-66.

Xu Y, Guo C, Yang J, Yuan Z, Ho HC.  Modelling impact of high-rise, high-density built environment on COVID-19 risks: empirical results from a case study of two chinese cities.  Int J Environ Res Public Health 2023; 20(2): 1422.

Xue Q, Xing Q, Dong L, Guo M, Zhang X, Wei X, et al. ST36 acupoint injection with anisodamine for postoperative nausea and vomiting in female patients after bariatric surgery: a prospective, randomized controlled trial. Surg Endosc 2023; 37(8): 5999-6007.

Yang LQ, Zhu L, Shi X, Miao CH, Yuan HB, Liu ZQ, et al. Postoperative pulmonary complications in older patients undergoing elective surgery with a supraglottic airway device or tracheal intubation. Anaesthesia 2023; 78(8): 953-62.

Yang M, Wu K, Wu Q, Huang C, Xu Z, Ho HC, et al.   A systematic review and meta-analysis of air pollution and angina pectoris attacks: identification of hazardous pollutant, short-term effect, and vulnerable population.  Environ Sci Pollut Res Int 2023; 30(12): 32246-54.

Zheng H, Cheng J, Ho HC, Zhu B, Ding Z, Du W, et al.   Evaluating the short-term effect of ambient temperature on non-fatal outdoor falls and road traffic injuries among children and adolescents in China: a time-stratified case-crossover study.  Front Environ Sci Eng 2023; 17(9): 105.


Agarwal S, El-Boghdadly K, Bailey CR, Carlisle JB, Charlesworth M, Duggan LV, Irwin MG, et al. Position statement from the Editors of Anaesthesia on equity, diversity and inclusion. Anaesthesia 2022; 77(9): 1018-22.

Chan DYC, Li LF, Lui WM, Poon CMC, Tsang COA, Leung GKK. Predictive value of Bispectral Index (BIS) in emergency neurosurgical patients: loss of BIS reactivity to propofol predicts poor functional outcomes.  Clin Neurol Neurosurg 2022; 221: 107382.

Chan E, Khong ML, Torda A, Tanner JA, Velan GM, Wong GTC. Medical teachers' experience of emergency remote teaching during the COVID-19 pandemic: a cross-institutional study.  BMC Medical 2022; 22(1): 303.

Chan KY, Chan TSY, Gill H, Chan TCW, Li CW, Au HY, et al. Supportive care and symptom management in patients with advanced hematological malignancies: a literature review.  Ann Palliat Med 2022; 11(10): 3273-91.

Chan WKV, Chan PK, Yan CH, Fu CHH, Chan CWT, Chiu PKY. Effect of steroid in local infiltration analgesia in one-stage bilateral total knee arthroplasty: a paired-randomized controlled study.  J Knee Surg 2022; 35(3): 317-22.

Chen XK, Kwan JS, Wong GT, Yi ZN, Ma AC, Chang RC. Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio).  Exp Mol Med 2022; 54(7): 973-87.

Chen Y, Chu JMT, Chang RCC, Wong GTC. The complement system in the central nervous system: From neurodevelopment to neurodegeneration.  Biomolecules 2022; 12(2): 337.

Chen YL, Feng XL, Cheung CW, Liu JA. Mode of action of astrocytes in pain: From the spinal cord to the brain.  Prog Neurobiol 2022; 219: 102365.

Chen YW, Li YJ, Deng P, Yang ZY, Zhong KH, Zhang LG, et al. Learning to predict in-hospital mortality risk in the intensive care unit with attention-based temporal convolution network.  BMC Anesthesiol 2022; 22(1): 119.

Cheng C, Cushman SA, Ho HC, Gao P. Geographic complexity: concepts, theories, and practices. ISPRS Int J Geo-Inf 2022; 11(5): 308. 

Cheung VYT, Lam PWT, Lam SW. Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine adenomyosis: preliminary experience from a case series.  WJARR 2022; 13(02): 359-66.

Chu JMT, Abulimiti A, Wong SH, Zhao GD, Xiong SH, Zhao MM, Wang YY, Chen Y, Wang J, Zhang Y, Chang RCC, Yu H, Wong GTC. Sigesbeckia orientalis L. derived active fraction ameliorates perioperative neurocognitive disorders through alleviating hippocampal neuroinflammation.  Front Pharmacol 2022; 13: 846631.

Chung CKE, Poon CCM, Irwin MG. Peri‐operative neurological monitoring with electroencephalography and cerebral oximetry: a narrative review.  Anaesthesia 2022; 77(S1): 113-22.

Cong J, Wang LB, Liu FJ, Qian ZM, McMillin SE, Vaughn MG, et al. Associations between metabolic syndrome and anthropogenic heat emissions in northeastern China.  Environ Res 2022; 204(Pt A): 111974.

Curtin J, Wong G, Wang W, Thomson P, Lam AK, Choi SW. A comparison of two methods for the detection of circulating tumour cells in patients with oral cavity cancer.  J Oral Pathol Med 2022; 51(3): 249-55.

Deng W, Wang S, Lam PK, Rainer TH, Irwin MG. Repurposing polyvinyl chloride pipes in the emergency department for COVID-19.  Ann Emerg Med 2022; 80(3): 282-4.

Gong T, Liu Y, Tian Z, Zhang M, Gao H, Peng Z, Yin S, Cheung CW, Liu Y. Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning.  Front Immunol 2022; 13: 995974.

He WQ, Li YJ, Li YS, Zhang XH, Cao J, Lu KZ, et al. Advantages of transmuscular quadratus lumborum block via subfascial approach versus extrafascial approach for postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled study. Clin J Pain 2022; 38(12):730-8.

He Y, Cai Y, Sun T, Zhang L, Iriwn MG, Xu Aimin, Xia Z. MicroRNA-503 exacerbates myocardial ischemia/reperfusion injury via inhibiting PI3K/Akt- and STAT3-dependent prosurvival signaling pathways.  Oxid Med Cell Longev 2022; 2022: 3449739.

He Y, Sun Y, Liao C, Lin F, Xia Z, Qi Y, Chen Y. The protective role of hydrogen sulfide and its impact on gene expression profiling in rat model of COPD.  Oxid Med Cell Longev 2022; 2022: 9407927.

Ho HC, Cheng W, Song Y, Liu Y, Guo Y, Lu S, Lum TYS, Chiu R, Wsbster C. Spatial uncertainty and environment-health association: an empirical study of osteoporosis among “old residents” in public housing estates across a hilly environment.  Soc Sci Med 2022; 306: 115155.

Ho HC, Lau K, Ren C, Wang D. Systematic identification of heat events associated with emergency admissions to enhance the heat-health action plan in a subtropical city: a data-driven approach.  Environ Sci Pollut Res Int 2022; 29(59): 89273-282.

Ho HC, Sim T, Guo C. Association between awareness of vulnerability and disaster preparedness in an infrastructure-resilient city: a population-based study.  Public Health 2022; 209: 23-29.

Ho HC, Wang D, Leung J, Yu B, Woo J, Kwok CYT, Lau K. “Planned Greenspace” or “Natural Greenspace” in a high-density city with compact environment? An empirical study of osteoporosis among senior population. Build Environ 2022; 219: 109117.

Ho YS, Chang RCC, Wong GTC, Yeung WF, Zhang HQ. Effects of electroacupuncture on postoperative cognitive dysfunction: a preclinical study (abridged secondary publication).  Hong Kong Med J 2022; 28S6(6): 45-7.

Huang CX, Chu JMT, Liu Y, Kwong VSW, Chang RCC, Wong GTC. Sevoflurane induces neurotoxicity in the animal model with Alzheimer’s disease neuropathology via modulating glutamate transporter and neuronal apoptosis.  Int J Mol Sci 2022; 23(11): 6250.

Kimura LF, Novaes LS, Picolo G, Munhoz CD, Cheung CW, Camarini R. How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders. Br J Pharmacol 2022; 179(8): 1640-60.

Kong CW, Chiu TL, Cheung CW, Lee TY, Yeung FK, Yu SK. The impact of the ClearRT upgrade on target motion tracking accuracy in Radixact® Synchrony® lung treatments.  Rep Pract Oncol Radiother 2022; 27(6): 1106-13.

Lai AKW, Ng TC, Hung VKL, Tam KC, Cheung CW, Chung SK, Lo ACY. Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion.  Neural Regen Res 2022; 17(7): 1566-75.

Lam WL, Ngan HYS, Chan KKL, Chen H, Cheung CW, Jiang F, Wong CKH, Yeung WF, Leo L. Combined electroacupuncture and auricular acupuncture to alleviate pain after gynaecological abdominal surgery: a randomised sham-controlled trial (abridged secondary publication).  Hong Kong Med J 2022; 28S1(1): 27-30.

Lam WL, Wang J, Yeung WF, Cheung CW, Chan KKL, Ngan HYS, et al. A combination of electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynaecological diseases: a randomized controlled trial.  Phytomedicine 2022; 104: 154292.

Li C, Tang W, Ho HC, Zhao P, Chen L, Wang Y, Xiong M, Yang B, Zheng H, Wang C. Online sex-seeking among Chinese heterosexual men who seek care in sexually transmitted infections clinics: a cross-sectional study.  Arch Public Health 2022; 80(1): 149.

Li W, Liu C, Ho HC, Shi L, Zeng Y, Yang X, Huang Q, Pei Y, Huang C, Yang L . Association between antibiotic resistance and increasing ambient temperature in China: An ecological study with nationwide panel data.  Lancet Reg Health West Pac 2022; 30: 100628.

Liu J, Ho HC. A framework for characterizing the multilateral and directional interaction relationships between PM pollution at city scale: a case study of 29 cities in East China, South Korea and Japan.  Front Public Health 2022; 10: 875924.

Liu Y, Chu JMT, You R, Zhang Y, Chang RCC, Wong GTC. Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders.  J Neuroinflammation 2022; 19(1): 150.

Lu W, Tang S, Li A, Huang Q, Dou M, Zhang Y, et al. The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders. Front Aging Neurosci 2022; 14: 973068.

Nestor CC, Irwin MG. Spinal vs. general anesthesia for hip-fracture surgery. N Engl J Med 2022; 386(8): 801-3.

Nestor CC, Ng C, Sepulveda P, Irwin MG. Pharmacological and clinical implications of local anaesthetic mixtures: a narrative review. Anaesthesia 2022; 77(3): 339-50.

Nestor CC, Sepulveda PO, Irwin MG. What version of Hell's Kitchen? A reply. Anaesthesia 2022; 77(7): 840-1.

Nestor CC, Sepulveda PO, Irwin MG . Drug mixtures and infusion technology: replies. Anaesthesia 2022; 77(7): 837-8.

Nestor CC, Sepulveda PO, Irwin MG. Drug mixtures and infusion technology. MasterChef or Hell’s Kitchen? Anaesthesia 2022; 77(3): 260-3.

Ng PY, Ip SWA, Fang S, Lin JCR, Ling L, Chan KM, Leung KHA, Chan KCK, So D, Shum HP, Ngai CW, Chan WM, Sin WC. Effect of hospital case volume on clinical outcomes of patients requiring extracorporeal membrane oxygenation: a territory-wide longitudinal observational study.  J Thorac Dis 2022; 14(6): 1802-14.

Ng PY, Li ACC, Fang S, Lin JCR, Ip SWA, Chan WM, Sin WC, Ngai CW. Predictors of favorable neurologic outcomes in a territory-first extracorporeal cardiopulmonary resuscitation program. ASAIO J 2022; 68(9): 1158-64.

Ng PY, Ma TSK, Ip SWA, Lee MK, Ng AKY, Ngai CW, Chan KM, Siu DCW, Sin WC. Sensitivity of ventricular systolic function to afterload during veno‐arterial extracorporeal membrane oxygenation.  ESC Heart Fail 2022; 9(5): 3241-53.

Ning Z, Gu P, Zhang J, Cheung CW, Lao L, Chen H, Zhang Z. Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord. Brain Behav Immun 2022; 99: 43-52.

Qiu Q, Chew CJ, Irwin MG. Opioid MOP receptor agonists in late-stage development for the treatment of postoperative pain. Expert Opin Pharmacother 2022; 23(16): 1831-43.

Wan EYF, Li Z, Sun KS, Chan KHY, Cheung WHG, Chan M, et al. Identifying and articulating the student experience in the Intercalated Enrichment Year.  BMC Med Educ 2022; 22(1): 246.

Wang Y, Li C, Ruan Z, Ye R, Yang B, Ho HC. Effects of ambient exposure to nitrogen dioxide on outpatient visits for psoriasis in rapidly urbanizing areas. AAQR 2022; 22(8): 220166.

Wong ASK, Ma TSK, Chu YLE, Chan TB, Sin SWC. Buttock ischemia in venoarterial extracorporeal membrane oxygenation: a case series.  ASAIO J 2022; 68(12): e256-61.

Wong JYH, Ko HKJ, Nam S, Kwok TO, Lam WH, Cheuk YY, Chan MMK, Lam SF, Wong GTC, NG LH, Wai KCA. Virtual ER, a serious game for interprofessional education to enhance teamwork in medical and nursing undergraduates: development and evaluation study.  JMIR Serious Games 2022; 10(3): e35269.

Wong SSC, Choi EKY, Chan WS, Cheung CW. Propofol total intravenous anaesthesia versus inhalational anaesthesia for acute postoperative pain in patients with morphine patient-controlled analgesia: a large-scale retrospective study with covariate adjustment. BMC Anesthesiol 2022; 22(1): 140.

Wu K, Ho HC, Su H, Huang C, Zheng H, Zhang W, et al. A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: first few hours of exposure matters to life. eBioMedicine 2022; 86: 104327.

Yang H, Shan Z, Guo W, Wang Y, Cai S, Li F, Huang Q, Liu JA, et al. Reversal of peripheral neuropathic pain by the small-molecule natural product Narirutin via block of Nav1.7 voltage-gated sodium channel.  Int J Mol Sci 2022; 23(23): 14842.

Yim RLH, Leung KMM, Poon CCM, Irwin MG. Peri‐operative management of patients with Parkinson’s disease. Anaesthesia 2022; 77(S1): 123-33.

Yu MON, Chung PHY, Wong M, Kwan A, Chee YE, Wong KKY. Thoracoscopic repair of congenital oesophageal atresia in a newborn: a case report.  Hong Kong Med J 2022; 28(1): 73-75.

Zhang Y, Chu JMT, Wong GTC. Cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction.  Biomolecules 2022; 12(4): 597.

Zhu D, Fan T, Chen Y, Huo X, Li Y, Liu D, Cai Y, Chueng CW, Tang J, Cui J, Xia Z. CXCR4/CX43 regulate diabetic neuropathic pain via intercellular interactions between activated neurons and dysfunctional astrocytes during late phase of diabetes in rats and the effects of antioxidant N-Acetyl-L-Cysteine.  Oxid Med Cell Longev 2022; 2022: 8547563.


Aitkenhead AR, Irwin MG. Deaths associated with anaesthesia - 65 years on. Anaesthesia 2021; 76(2): 277-80.

Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, Wang S, Xu A, Xia Z. Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling. Theranostics 2021; 11: 4710-27.

Chan E, Botelho MG, Wong GTC. A flipped classroom, same-level peer-assisted learning approach to clinical skill teaching for medical students. PLoS One 2021; 16(10): e0258926.

Chan WKV, Chan PK, Fu H, Chan CW, Yan CH, Chiu KY. Combination effect of high-dose preoperative and periarticular steroid injection in total knee arthroplasty. A randomized controlled study. J Arthroplasty 2021; 36(1): 130-4.e2.

Chen XK, Yi ZN, Wong GT, Hasan KMM, Kwan JSK, Ma ACH, Chang RCC. Is exercise a senolytic medicine? a systematic review. Aging Cell 2021; 20(1): e13294.

Deng L, Lei S, Wang X, Jiang F, Lubarsky DA, Zhang L, Liu D, Han C, Zhou D, Wang Z, Sun X, Zhang Y, Cheung CW, Wang S, Xia Z, Applegate RL, Tang J, Mai Z, Liu H, Xia Z. Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysis. Aging (Albany NY) 2021; 13(12): 15801-14.

Green SM, Irwin MG, Manson KP. Procedural sedation: providing the missing definition. Anaesthesia 2021; 76(5): 598-601.

Gu P, Fan T, Wong SSC, Pan Z, Tai WL Chung SK, Cheung CW. Central Endothelin-1 confers analgesia by triggering spinal neuronal histone deacetylase 5 (HDAC5) nuclear exclusion in peripheral neuropathic pain in mice. J Pain 2021; 22(4): 454-71.

Han X, Lu Y, Fang Q, Fang P, Wong GTC, Liu X. Effects of epidural anesthesia on quality of life in elderly patients undergoing esophagectomy. Semin Thorac Cardiovasc Surg 2021; 33(1): 276-85.

Lam DMH, Wang C, Lee AKH, Chung YF, Lau TW, Fang C, Leung F, Chan CWT. Multi-component care bundle in geriatric fracture hip for reducing post-operative delirium. Geriatr Orthop Surg Rehabil 2021; 12: 21514593211004530.

Lam SW, Irwin MG. Pre‐oxygenation for rapid sequence induction: is high‐flow nasal oxygenation worth the hassle? Anaesthesia 2021; 76(9): 1159-62.

Li S, Li X, Xie X, Wei X, Yu C, Cheung CW, Xia Z, Tian G. N-Acetylcysteine attenuates hyperalgesia in rats with diabetic neuropathic pain: role of oxidative stress and inflammatory mediators and CXCR4. J Diabetes Res 2021; 2021: 8862910.

Liu JA, Yu J, Cheung CW. Immune actions on the peripheral nervous system in pain. Int J Mol Sci 2021; 22(3): 1448.

Liu X, Hu J, Hu X, Li R, Li Y, Wong GTC, Zhang Y, et al. Preemptive intravenous nalbuphine for the treatment of post-operative visceral pain: a multicenter, double-blind, placebo-controlled, randomized clinical trial. Pain Ther 2021; 10(2): 1155-69.

Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, et al. Effect of intraoperative dexmedetomidine on recovery of gastrointestinal function after abdominal surgery in older adults: a randomized clinical trial. JAMA Netw Open 2021; 4(10): e2128886.

Nestor CC, Kearsley R, Irwin MG. Anaesthetic implications for a malignant hyperthermia‐susceptible fetus. Anaesthesia 2021; 76(9): 1281-82.

Nestor CC, Wang S, Irwin MG. Are tracheal intubation and extubation aerosol-generating procedures? Anaesthesia 2021; 76(2): 151-5.

Shi Y, Lau AKH, Ho HC, Bilal M. A multiscale land use regression approach for estimating intraurban spatial variability of PM 2.5 concentration by integrating multisource datasets.  Int J Environ Res Public Health 2021; 19(1): 321.

Sun L, Peng C, Joosten E, Cheung CW, Tan F, Jiang W, Shen X. Spinal cord stimulation and treatment of peripheral or central neuropathic pain: mechanisms and clinical application. Neural Plast 2021; 2021: 5607898.

Tai WL, Sun LT, Li H, Gu P, Joosten EA, Cheung CW. Additive effects of environmental enrichment and ketamine on neuropathic pain relief by reducing glutamatergic activation in spinal cord injury in rats. Front Neurosci 2021; 15: 635187.

Tsai KF, Shen CJ, Cheung CW, Wang TL, Chow LWC, Leung YM, Wong KL. Lipotoxicity in human lung alveolar type 2 A549 cells: mechanisms and protection by tannic acid. Chin J Physiol 2021; 64(6): 289-97.

Tsang HYS, Ma KW, She WH, Chu SKF, Lau WHV, Lam SW, Cheung TT, Lo CM. High-intensity focused ultrasound ablation of liver tumors in difficult locations. Int J Hyperthermia 2021; 38(2): 56-64.

Wang L, Cai Y, Jian L, Cheung CW, Zhang L, Xia Z. Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy. Cardiovasc Diabetol 2021; 20(1): 2.

Wong GTC, Irwin MG. Post-induction hypotension: a fluid relationship? Anaesthesia 2021; 76(1): 15-8.

Wong KW, Lam PK, Sin WC, Irwin MG, Rainer TH. Comparison of the efficiency and usability of aerosol box and intubation tent on intubation of a manikin using personal protective equipment: a randomized crossover study. J Emerg Med 2021; 61(6): 695-704.

Xiong W, Xiong SH, Chen QL, Linghu KG, Zhao GD, Chu MT, Wong GTC, Li J, Hu YJ, Wang YT and Yu H. Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs. Carbohydr Polym 2021; 266: 118112.

Xu J, Gao P, Wu Y, Yin S, Zhu L, Xu S, Tang D, Cheung CW, Jiao Y, Yu W, Li Y, Yang L. G protein‐coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain. CNS Neurosci Ther 2021; 27(11): 1313-26.

Yang L, Chan KL, Yuen JWM, Wong FKY, Han L, Ho HC, et al. Effects of urban green space on cardiovascular and respiratory biomarkers in Chinese adults: panel study using digital tracking devices. JMIR Cardio 2021; 5(2): e31316.

Yeung PNP, Fang S, Ip SWA, Ng KYA, Chan WM, Sin WC, Ngai CW. Changes in patterns of extracorporeal cardiopulmonary resuscitation during the COVID-19 pandemic. J Thorac Dis 2021; 13(11): 6499-501.

Yeung SC, Ganesan K, Wong SCS, Chung SK, Cheung CW. Characterization of acute pain‐induced behavioral passivity in mice: Insights from statistical modeling. Eur J Neurosci 2021; 53(9): 3072-92.

Yeung SC, Irwin MG, Cheung CW. Environmental enrichment in postoperative pain and surgical care: potential synergism with the enhanced recovery after surgery pathway. Ann Surg 2021; 273(1): 86-95.


Bu X, Li T, Wang H, Xia Z, Guo D, Wang J, Sun Y, Yang C, Liu G, Ma J, Yang Z, Wang G. Combination of isoflurane and propofol as general anesthesia during orthopedic surgery of perioperative cerebral hypoperfusion rats to avoid cognitive impairmentFront Med (Lausanne) 2020; 7: 549081.

Cai Y, Ying F, Liu H, Ge L, Song E, Wang L, Zhang D, Tang EHC, Xia Z, Irwin MG. Deletion of Rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of STAT3 signalingFASEB J 2020; 34(3): 4482-96.

Chan EYF, Ip DKY, Irwin MG. Anesthetic Management for Squamous Cell Carcinoma of the EsophagusMethods Mol Biol 2020; 2129: 359-83.

Chan PK, Hwang YY, Cheung A, Yan CH, Fu H, Chan T, Fung WC, Cheung MH, Chan VWK, Chiu KY. Blood transfusions in total knee arthroplasty: a retrospective analysis of a multimodal patient blood management programmeHong Kong Med J 2020; 26(3): 201-07.

Chan SP, Ip KY, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative reviewAnaesthesia 2020; 74 (S1): 80-89.

Chan TCW, Cheung CW, Wong SSC, Chung AYF, Irwin MG, Chan PK, Fu H, Yan CH, Chiu KY. Preoperative dexamethasone for pain relief after total knee arthroplasty: a randomised controlled trialEur J Anaesthesiol 2020; 37(12): 1157-67.

Chen K, Yu J, Wang Q, Wu L, Liu X, Wong GTC, Lu Y. The timing of propofol administration affects the effectiveness of remote ischemic preconditioning induced cardioprotection in ratsJ Cell Biochem 2020; 121(11): 4535-41.

Chok KSH, Hui JYM, Wong GTC. A rare case of propofol-induced acute hepatitis in after a brief Endoscopic Retrograde Cholangio-Pancreatography (ERCP)Surgical Case Reports 2020. 3(2): 1-3.

Chow VLY, Chan JYW, Ho VWY, Pang SSY, Lee GCC, Wong MMK, Lo ASH, Lui F, Poon CMC, Wong STS. Tracheostomy during COVID-19 pandemic – a novel approachHead Neck 2020; 42(7): 1367-73.

Green SM, Irwin MG, Mason KP. Consensus statement on fasting before procedural sedation - underestimating the threat to patient safety? A reply. Anaesthesia 2020; 75(6): 830-32.

Green SM, Leroy PL, Roback MG, Irwin MG, et alAn international multidisciplinary consensus statement on fasting before procedural sedation in adults and childrenAnaesthesia 2020; 75(3): 374-85.

Ho YS, Zhao FY, Yeung WF, Wong GTC, Zhang HQ, Chang RCC. Application of acupuncture to attenuate immune responses and oxidative stress in postoperative cognitive dysfunction: what do we know so far? Oxid Med Cell Longev 2020; 2020: 9641904 1-21.

Irwin MG. Difficult Airway Society guidelines for awake tracheal intubation in adults. Anaesthesia 2020; 75(5): 688.

Irwin MG, Chung CKE, Ip KY, Wiles MD. Influence of propofol-based total intravenous anaesthesia on peri-operative outcome measures: a narrative reviewAnaesthesia 2020; 75(S1): e90-e100.

Irwin MG, Chung CKE, Wong GTC. Measuring the effect-siteAnesthesia 2020; 75(12): 1583-86.

Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)J Gen Intern Med 2020; 35(5): 1545-49.

Khong ML, Chan E, Tanner JA, Lee PPW, Wong GTC. COVID-19 – A covert catalyst for pedagogical stocktake and transformation: perspectives of a global hubMedEdPublish 2020. 9(1): 212.

Lam KK, Leung MKM, Irwin MG. Labour analgesia: update and literature review. Anaesthesia 2020; 26(5): 413-20.

Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, Zhan LY, Jia Y, Zhang L, Liu D, Xia ZY, Xia Z. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infectionEClinicalMedicine 2020; 21: 100331.

Lei S, Jiang F, Xia ZY, Xia Z. Author's reply - Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infectionEClinicalMedicine 2020; 22: 100363.

Li P, Li X, Deng P, Wang D, Bai X, Li Y, Luo C, Belguise K, Wang X, Wei X, Xia ZY, Yi B. Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly ratsAging (Albany NY) 2020; 13(1): 694-713.

Li YJ, Zhang LG, Zhi HY, Zhong KH, He WQ, Chen Y, Yang ZY, Chen L., Bai XH, Qin XL, Li DF, Wang DD, Gu JT, Ning JL, Lu KZ, Zhang J, Xia ZY, Chen Y, Yi B. A better method for the dynamic, precise estimating of blood/ haemoglobin loss based on deep learning of artificial intelligenceAnn Transl Med 2020; 8(19): 1219.

Li YY, Wang Y, Li Y, Zhong M, Liu H, Wu C, Guo X, Xia Z, Ma W. Comparison of repeated video display vs combined video display and live demonstration as training methods to healthcare providers for donning and doffing personal protective equipment: a randomized controlled trialRisk Manag Healthc Policy 2020; 13: 2325-35.

Liu J, Xie X, Yan D, Wang Y, Yuan H, Cai Y, Luo J, Xu A, Huang Y, Cheung CW, Irwin MG, Xia Z. Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic ratsJ Cell Mol Med 2020; 24(23): 13727-38.

Liu JA, Tai A, Hong J, Cheung MPL, Sham MH, Cheah KSE, Cheung CW, Cheung M. Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilizationProc Natl Acad Sci USA 2020; 117(8): 4199-4210.

Liu Y, Chu JMT, Yan T, Zhang Y, Chen Y, Chang RCC, Wong GTC. Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease miceJ Neuroinflammation 2020; 17(1): 4 .

Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut microbiome fermentation determines the efficacy of exercise for diabetes preventionCell Metab 2020; 31(1): 77-91.

Liu Z, Xu S, Ji Z, Xu H, Zhao W, Xia Z, Xu R. Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stressAging (Albany NY) 2020; 12(13): 13463-76.

Liu Z, Zhao W, Yuan P, Zhu P, Fan K, Xia Z, Xu S. The mechanism of CaMK2α-MCU-mitochondrial oxidative stress in bupivacaine-induced neurotoxicityFree Radic Biol Med 2020; 152: 363-74.

Luo J, Yan D, Li S, Liu S, Zeng F, Cheung CW, Liu H, Irwin MG, Huang H, Xia Z. Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats.  J Cell Mol Med 2020; 24(2): 1760-73.

Peng K, Liu H, Yan B, Meng XW, Song SY, Ji FH, Xia Z. Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosisJ Cell Physiol 2020; 236(2): 1309-20.

Su W, Qiu Z, Zhou L, Hou J, Wang Y, Huang F, Zhang Y, Jia Y, Zhou J, Liu D, Xia Z, Xia ZY, Lei S. Sex differences in clinical characteristics and risk factors for mortality among severe patients with COVID-19: a retrospective studyAging (Albany NY) 2020; 12(19): 18833-43.

Sun LT, Fleetwood-Walker S, Mitchell R, Joosten EA, Cheung CW. Prolonged analgesia by spinal cord stimulation following a spinal injury associated with activation of adult neural progenitorsPain Pract 2020; 20(8): 859-77.

Wang C, Yuan W, Hu A, Lin J, Xia Z, Yang CF, Li Y, Zhang Z. Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injuryMol Med Rep 2020; 22(1): 175-84.

Wang C, Zhu L, Yuan W, Sun L, Xia Z, Zhang Z, Yao W. Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent mannerJ Cell Mol Med 2020; 24(12): 6670-79.

Wang K, Wu C, Xu J, Zhang B, Zhang X, Gao Z, Xia Z, Factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: a systematic review and meta-analysisEClinicalMedicine 2020; 29: 100612.

Wang S, Ge L, Zhang D, Wang L, Liu H, Ye X, Liang W, Li J, Ma H, Cai Y, Xia Z. MiR-181c-5p promotes inflammatory response during hypoxia/reoxygenation injury by downregulating protein tyrosine phosphatase nonreceptor type 4 in H9C2 cardiomyocytesOxid Med Cell Longev 2020; 2020: 7913418.

Wang SYS, Zhu S, Wu J, Zhang M, Xu Y, Xu W, Cui J, Yu B, Cao W, Liu J. Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathyJ Mol Med (Berl) 2020; 98(2): 245-61.

Wang XM, Gu P, Saligan L, Iadarola M, Wong SCS, Ti LK, Cheung CW. Dysregulation of EAAT2 and VGLUT2 spinal glutamate transports via histone Ddacetylase 2 (HDAC2) Ccntributes to paclitaxel-induced painful neuropathyMol Cancer Ther 2020; 19(10): 2196-209.

Wang XX, Sha X, Liu Y, Li C, Chen S, Wang J, Xia Z. Lung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in ratsBMC Anesthesiol 2020; 20(1): 188.

Wang Y, Zhou L, Su W, Huang F, Zhang Y, Xia ZY, Xia Z, Lei S. Selective inhibition of PKCβ2 restores ischemic postconditioning-mediated cardioprotection by modulating autophagy in diabetic ratsJ Diabetes Res 2020; 2020: 2408240.

Wong SSC, Chan WS, Cheung CW. Analgesic effects of cannabinoids for chronic non-cancer pain: a systematic review and meta-analysis with meta-regressionJ Neuroimmune Pharmacol 2020;15(4): 801-29.

Wong SSC, Chan WS, Fang C, Chan C, Lau TW, Leung F, Cheung CW. Infraclavicular nerve block reduces postoperative pain after distal radial fracture fixation: a randomized controlled trialBMC Anesthesiology 202020(1): 130.

WongSSC, Chan WS, Irwin MG, Cheung CW. Total intravenous anesthesia (TIVA) with Propofol for acute postoperative pain: a scoping review of randomized controlled trialsAsian J Anesthesiol 2020; 58(3): 79-93.

Wong SS, Cheung CW. Optimization of opioid utility in cancer pain populationsAnn Palliat Med 2020; 9(2): 558-70.

Wong SSC, Cheung CW. Analgesic efficacy and adverse effects of Meperidine in managing postoperative or labor pain: a narrative review of randomized controlled trialsPain Physician 2020; 23(2): 175-201.

Wu B, Hong H, Xia Z, Liu H, Chen X, Chen J, Yan B, Liang Y. Transcriptome analyses unravel CYP1A1 and CYP1B1 as novel biomarkers for disinfection by-products (DBPs) derived from chlorinated algal organic matterJ Hazard Mater 2020; 387: 121685.

Xia Z. Eosinopenia as an early diagnostic marker of COVID-19 at the time of the epidemicEClinicalMedicine 2020; 23: 100398.

Yan D, Cai Y, Luo J, Liu J, Li X, Ying F, Xie X, Xu A, Ma X, Xia Z. FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetesJ Cell Mol Med 2020; 24(14): 7850-61.

Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, Zhang W, Zhang W, Li X. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosisCell Death Dis 2020; 11(10): 827.

Yang X, Hu F, Liu JA, Shan Y, Cheung MPL, Liu XL, Ng IOL, Guan XY, Wong KKW, Sharma R, Lung HL, Jiao YF, Lee LTO, Cheung M. Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanomaOncogene 2020. 39(20): 4061-76.

Ye QP, Wu D, Fang WP, Wong GTC, Lu Y. Comparison of gastric insufflation using LMA-supreme and I-gel versus tracheal intubation in laparoscopic gynecological surgery by ultrasound: a randomized observational trialBMC Anesthesiol 2020, 20(1): 136.

Zhang D, He Y, Ye X, Cai Y, Xu J, Zhang L, Li M, Liu H, Wang S, Xia Z. Activation of autophagy inhibits nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic ratsJ Diabetes Investig 2020; 11(5): 1126-36.

Zhang D, Mei L, Long R, Cui C, Sun Y, Wang S, Xia Z. RiPerC attenuates cerebral ischemia injury through regulation of miR-98/PIK3IP1/PI3K/AKT signaling pathwayOxidMed Cell Longev 2020; 2020: 645428.

Zhu Q, Li H, Xie X, Chen X, Kosuru R, Li S, Lian Q, Cheung CW, Irwin MG, Ge RS, Xia ZAdiponectin facilitates postconditioning cardioprotection through both AMPK-dependent nuclear and AMPK-independent mitochondrial STAT3 activationOxid Med Cell Longev 2020; 2020: 4253457.


Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG et al. Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine. Br J Anaesth 2019; 122(5): 542-51.

Chan SP, Ip KY, Irwin MG. Peri-operative optimization of elderly and frail patients: a narrative review. Anaethesia 2019; 74 (S1): 80-9.

Chen K, Wang L, Wang Q, Liu X, Lu Y, Li Y, Wong GTC. Effects of pneumoperitoneum and steep trendelenburg position on cerebral hemodynamics during robotic-assisted laparoscopic radical prostatectomy: a randomized controlled study. Medicine 2019; 98(21): e15794.

Cheung CW. Epidural steroids – are we following the guidelines? Anaesthesia 2019; 74(12): 1500-03.

Cheung VYT, Lam TPW, Jenkins CR, Lam SW, Cheung GKI, Chan SSY, Choi WK. Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine fibroids: a preliminary experience. J Obstet Gynaecol 2019; 39(6): 833-9.

Cheung V, Yuen VMY, Wong GTC, Choi SW. The effect of sleep deprivation and disruption on DNA damage and health of doctors. Anaesthesia 2019; 74(4): 434-40.

Choi SW, Leung FKL, Lau TW, Wong GTC. Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative management. HIP Int 2019; 29(2): 172-6.

Chow LWC, Cheng KS, Leong F, Cheung CW, Shiao LR, Leung YM, Wong KL. Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production. Naunyn Schmiedebergs Arch Pharmacol 2019; 392(4): 427-36.

Ge L, Cai Y, Ying F, Liu H, Zhang D, He Y, Pang L, Yan D, Xu A, Ma H, Xia Z. miR-181c-5p exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis via targeting PTPN4. Oxid Med Cell Longev 2019; 2019: 1957920.

Ge ZD, Lian Q, Mao X, Xia Z. Current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathy. Int Heart J 2019; 60(3): 512-20.

Huang C, Ng OT, Chu JM, Irwin MG, Hu X, Zhu S, Chang RC, Wong GT. Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice. Neurosci Lett 2019; 707: 134309.

Ip KY, Tsai NWP, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative review. Anaesthesia 2019; 74 (S1): 80-9.

Irwin MG, Ip KY, Hui YM. Anaesthetic considerations in nonagenarians and centenarians. Curr Opin Anaesthesiol 2019; 32(6): 776-82.

Irwin MG, Wong GTC. Taking on TIVA. Why we need guidelines on total intravenous anaesthesia. Anaesthesia 2019; 74(2): 140-2.

Kumar CM, Seet E, Eke T, Irwin MG, Joshi GP. Peri-operative considerations for sedation-analgesia during cataract surgery: a narrative review. Anaesthesia 2019; 74(12), 1601-10.

Lee LKK, Tsai NWP, Ip KY, Irwin MG. Pre-operative cardiac optimization: a directed review. Anaesthesia 2019; 74(S1): 67-9.

Liu Y, Yan T, Chu MT, Chen Y, Dunnett SL, Ho YS, Wong GTC, Chang RCC. The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Lab Invest 2019; 99(7): 943-57.

Lei S, Su W, Xia ZY, Wang Y, Zhou L, Qiao S, Zhao B, Xia Z, Irwin MG. Hyperglycemia-induced oxidative stress abrogates remifentanil preconditioning-mediated cardioprotection in diabetic rats by impairing Caveolin-3-modulated PI3K/Akt and JAK2/STAT3 signaling. Oxid Med Cell Longev 2019; 2019: 9836302.

Liu Y, Paterson M, Baumgardt SL, Irwin MG, Xia Z, Bosnjak ZJ, Ge ZD. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning. Cardiovasc Res 2019; 115(1):168-78.

McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F et al. Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122(5): 575-86.

Qin Z, Xiang C, Li H, Liu T, Zhan L, Xia Z, Zhang M, Lai J. The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial. BMC Anesthesiol 2019; 19(1): 181.

Sanders RD, Hughes F, Shaw A, Thompson A, Bader A et al. Perioperative quality initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122(5): 552-62.

Sessier DI, Blookstone JA, Aronson S, Berry C, Gan T et al. Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122(5): 563-74.

Shi DD, Huang YH, Lai CSW, Dong CM, Ho LC, Li XY, Wu EX, Li Q, Wang XM, Chen YJ, Chung SK, Zhang Z. Ginsenoside Rg1 prevents chemotherapy-induced cognitive impairment: associations with microglia-mediated cytokines, neuroinflammation, and neuroplasticity. Mol Neurobiol 2019; 56(8): 5626-42.

Song SY, Meng XW, Xia Z, Liu H, Zhang J, Chen QC, Liu HY, Ji FH, Peng K. Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane. Aging (Albany NY) 2019; 11(19): 8386-8417.

Sun L, Ma W, Gao W, Xing Y, Chen L, Xia Z, Zhang Z, Dai Z. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome. Cell Death Dis 2019; 10(8): 542.

Tsai NW, Leung YM, Ng PY. Liong T, Lee SF, Ngai CW, Sin WC, Koo J, Chan WM. Attitudes of visitors at adult intensive care unit toward organ donation and organ support. Chin Med J (Engl) 2019; 132(3): 373-6.

Ward PA, Irwin MG. Airway management research and the need for consensus. Anaesthesia 2019; 74(7): 942.

Wang TT, Shi MM, Liao XL, Li YQ, Yuan HX, Li Y, Liu X, Ning DS, Peng YM, Yang F, Mo ZW, Jiang YM, Xu YQ, Li H, Wang M, Ou ZJ, Xia Z, Ou JS. Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioning. J Mol Cell Cardiol 2019; 129: 144-53.

Wong SCS, Lee UM, Wang XMA, Chung SK, Cheung CW. Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice. Neurosci Lett 2019; 709: 134379.

Wong SCS, Leung MYY, Cheung CW. The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trial. Eur J Pain 2019; 23(5): 884-93.

Wong SCS, Sun LT, Qiu Q, Gu P, Li Q, Wang XMA, Cheung CW. Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. Eur J Pain 2019; 23(4): 812-22.

Wu B, Hong H, Xia Z, Liu H, Chen X, Chen J, Yan B, Liang Y. Transcriptome analyses unravel CYP1A1 and CYP1B1 as novel biomarkers for disinfection by-products (DBPs) derived from chlorinated algal organic matter. J Hazard Mater 2019; 12: 121685.

Xiong W, Zhao GD, Yin X, Linghu KG, Chu MT, Wong GTC, Li H, Yu H, Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigations. Carbohydr Polym 2019; 204: 89-96.

Ye X, Zhang D, Wang S, Irwin MG, Xia Z. Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury. The FASEB J 2019; 33(S1): A514.11.

You R, Liu Y, Chang RCC. A behavioral test battery for the repeated assessment of motor skills, mood, and cognition in mice. J Vis Exp 2019; doi: 10.3791/58973.

Yuen VMY, Cheuk DK, Hui TW, Wong IC, Lam WW, Irwin MG. Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicenter study. Hong Kong Med J 2019; 25(S3): 27-9.

Zhu D, Fan T, Huo X, Cui J, Cheung CW, Xia Z. Progressive increase of inflammatory CXCR4 and TNF-Alpha in the dorsal root ganglia and spinal cord maintains peripheral and central sensitization to diabetic neuropathic pain in rats. Mediators Inflamm 2019; 2019: 4856156.


Chang L, Ye F, Luo Q, Wang Z, Wang Y, Xia Z, Shu H. Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesiaBioSci Trends 2018; 12(2): 177-184.

Chen X, Wang Y, Xie X, Chen H, Zhu Q, Ge Z, Wei H, Deng J, Xia Z, Lian Q. Heme oxygenase-1 reduces sepsis-induced endoplasmic reticulum stress and acute lung injury. Mediator Inflamm 2018; 2018: 9413876(1-10).

Choi SW, Charlesworth M, Wong GTC. A good pilot to navigate troubled watersAnaesthesia 2018; 73(4): 512-4.

Choi SW, Wong GTC. Doctor, why are you driving a wedge between us? Calculating sample size in multiple testing and the need for Geisser-Greenhouse correction. Anaesthesia 2018; 73(12): 1564-66.

Choi SW, Wong GTC. Quality improvement studies - pitfalls of the before and after study design. Anaesthesia 2018; 73(11): 1432-35.

Choi SW, Wong GTC. Assumptions and associations under pressure. Anaesthesia 2018; 73(7): 901-3.

Choi SW, Wong GTC. The art and science of statistical predictions: does a picture need a thousand words? Anaesthesia 2018; 73(6): 784-7.

Choi SW, Wong GTC. Before and after studies and historical controls. Is the proof in the pudding? Anaesthesia 2018; 73(5): 642-4.

Choi SW, Wong GTC. Big data, big problems: causation, confounders and cohorts. Anaesthesia 2018; 73(3): 384-7.

Chu JMT, Xiong W, Linghu KG, Liu Y, Zhang Y, Zhao GD, Irwin MG, Wong GTC, Yu H. Siegesbeckia Orientalis L. Extract attenuates postoperative cognitive dysfunction, systemic inflammation, and neuroinflammation. Exp Neurobiol 2018; 27(6): 564-73.

Ge L, Ma H, Cai Y, Pang L, Irwin MG, Xia Z. MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation. FASEB J 2018; 32(S1): A698.10.

Greenland K.B. and Irwin MG. Big data: breaking new ground in airway research. Anaesthesia 2018; 73(6): 674-8.

He Y, Cai Y, Yan D, Zhang D, Chen C, Irwin MG, Wang S, Xia Z. MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling FASEB J 2018; 32(S1): lb595.

Ho RHY, Irwin MG. Anaesthesia for major spinal surgery.   Anaesthe Intensive Care Med 2018; 19(4): 159-63.

Huang C, Irwin MG, Wong GTC, Chang RCC. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J Neuroinflammation 2018; 15(1): 147.

Huang C, Chu JM, Liu Y, Chang RCC, Wong GTC. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology 2018; 143: 217-27.

Irwin MG, Choi SW. If there is a 50-50 chance that something is correct, then nine times out of ten it will be… Bayesian network meta-analyses in Anaesthesia. Anaesthesia 2018; 73(8): 927-31.

Jin SY, Huang J, Zhu HJ, Wu H, XU SJ, Irwin MG, He SF, Zhang Y. Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heart. Eur J Pharmacol 2018; 828: 1-8.

Kosuru R, Cai Y, Kandula V, Yan D, Wang C, Zheng H, Li Y, Irwin MG, Singh S, Xia Z. AMPK contributes to cardioprotective effects of pterostilbene against myocardial ischemia- reperfusion injury in diabetic rats by suppressing cardiac oxidative stress and apoptosis. Cell Physiol Biochem 2018; 46(4): 1381-97.

Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats. Cardiovasc Drugs Ther 2018; 32(2): 147163.

Kwok DHY, Irwin MG. Preoperative assessment of the orthopaedic patient.   Anaesthe Intensive Care Med 2018; 19(4): 151-4.

Lam WL, Yeung WF, Wong MK, Cheung CW, Chan KKL, Ngan HYS, Wong CKH, Chen H, Lao L. Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trial. Trials 2018; 19(1): 8.

Lau YC, Irwin MG. Anaesthesia for joint replacement surgery.   Anaesthe Intensive Care Med 2018; 19(4): 171-4.

Li A, Yuen VM, Goulay-Dufay S, Sheng Y, Standing JF, Kwok PCL, Leung AS, Wong ICK, Irwin MG. Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine. Br J Anaesth 2018; 120(5): 960-8.

Li H, Irwin MG, Xia Z. Hyperglycemia-induced protein kinase Cβ2 activation causes diastolic cardiac dysfunction by disrupting Brg1-mediated suppression of RIP3 in diabetic rats. FASEB J 2018; 32(S1): A673.3.

Liu J, Yan D, Xie X, Xia Z. FOXO1 couples reactive oxygen species in diabetic atherosclerosis. FASEB J 2018; 32(S1): A569.8.

Liu SE, Irwin MG. Regional anaesthesia for orthopaedic procedures.   Anaesthe Intensive Care Med 2018; 19(4): 164-70.

Lu Y, Dai WC, Zong Z, Xiao Y, Wu DI, Liu X, Wong GTC. Bronchial blocker versus left double-lumen endotracheal tube for one-lung ventilation in right video-assisted thoracoscopic surgery. J Cardiothorac Vasc Anesth 2018; 32(1): 297-301.

Mohtar S, Hui TWC, Irwin MG. Anesthetic management of thoracoscopic resection of lung lesions in small children. Paediatr Anaesth 2018; 28(11): 1035-42.

Mu JJ, Jiang T, Deng LP, Choi SW, Irwin MG, Yuen VMY. A comparison of two techniques for induction of anaesthesia with target-controlled infusion of propofol. Anaesthesia 2018; 73(12): 1507-14.

Mu J, Jiang T, Xu XB, Yuen VMY, Irwin MG. Comparison of target-controlled infusion and manual infusion for Propofol anaesthesia in children. Br J Anaesth 2018; 120(5): 1049-55.

Pandit JJ, Irwin MG. Difficult airway society guidelines on the airway management of critically ill patients. A reply. Anaesthesia 2018; 73(8): 1036-37.

Pandit JJ, Irwin MG. Airway management in critical illness: practice implications of new Difficult Airway Society guidelines. Anaesthesia 2018; 73(5): 544-8.

Shi DD, Ding M, Ho LC, Lam CTW, Zhou XD, Wu EX, Zhou ZJ, Wang XM, Zhanf ZJ. Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: involvement of cytokine modulation and neuroprotectionNeurobiol Dis 2018; 114: 164-73.

Smith AS, Irwin MG. Researching research. Anaesthesia 2018; 73(6): 668-71.

Tai WL, Pan Z, Sun LT, Li H, Gu P, Wong SCS, Chung SK, Cheung CW. Suppression of Pax2 attenuates allodynia and hyperalgesia through ET-1–ETAR–NFAT5 signaling in a rat model of neuropathic pain. Neuroscience  2018; 384: 139-51.

Wong D, Tsai PNW, Ip KY, Irwin MG. New antihypertensive medications and clinical implicationsBest Pract Res Clin Anaesthesiol 2018; 32(2): 223-35.

Wong ESW, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PMGR. L-arginine and arginase products potentiate dexmedetomidine-induced contractions in the rat aorta. Anesthesiology 2018; 128: 564-73.

Wong KHK, Cai Y, Ying F, Chen X, Vanhoutte PM, Tang EHC. Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations. J Mol Cell Cardiol 2018; 115: 1-9.

Wong GTC. Patient emergence – statistical questionsAnaesthesia2018; 73(1): 130.

Wong GTC, Choi SW, Tran DHD, Kulkarni H, Irwin MG. An international survey evaluating factors influencing the use of total intravenous anaesthesia. Anaesth Intensive Care 2018; 46(3): 332-8.

Wong SCS, Choi SW, Cheung CW. A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong chinese population: an analysis of pain related outcomes and patient help seeking behaviour. PLoS One 2018; 13(10): e0204054.

Wong SCS, Choi SW, Lee Y, Irwin MG, Cheung CW. The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery. Medicine 2018; 97(31): e11615.

Wong GTC, Irwin MG. In Reply. A cost comparison between total intravenous and volatile anaesthesia.  Anaesth Intensive Care 2018; 46(6): 633-4.

Wong SCS, Irwin MG. Procedures under tourniquet.   Anaesthe Intensive Care Med  2018; 19(4): 155-8.

Wong SCS, Irwin MG. Anaesthesia and minimally invasive surgeryAnaesth Intensive Care Med 2018; 19(1): 11-5.

Wong SCS, Qiu Q, Cheung CW. Segmental spinal myoclonus complicating lumbar transforaminal epidural steroid injection. Reg Anesth Pain Med 2018; 43(5): 554-6.

Xie X, Yan D, Li H, Zhu Q, Li J, Fang YP, Cheung CW, Irwin MG, Xia Z, Lian Q. Enhancement of adiponectin ameliorates nonalcoholic fatty liver disease via inhibition of FoxO1 in type I diabetic rats. J Diabetes Res 2018; 2018: 6254340(1-9).

Yan D, Cai Y, Luo J, Liu J, Irwin MG, Xia Z. Pharmacologic inhibition of FOXO1 improves cardiac function by enhancing glucose metabolism and attenuating apoptosis in type-1 diabetic rats. FASEB J 2018; 32(S1): A838.2.

Ye XD, He Y, Wang S, Wong GTC, Irwin MG, Xia Z. Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis. Acta Pharmacol Sin 2018; 39(7): 1155-63.

You R, Ho YS, Hung HLC, Liu Y, Huang C, Chan HN, Ho SL, Lui SY, Li HW, Chang RCC. Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation. Part Fibre Toxicol 2018; 15(1): 28.

Ying F, Cai Y, Wong HK, CHen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A, Tang EHC. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids 2018; 1863(9): 1029-40.

Zhang C, Luo Q, Li Y, Wu X, Hao Z, Li S, Xia Z, Yan F, Sun L. Predictors of short-term outcomes following repair of anomalous origin of the left coronary artery from the pulmonary artery in Chinese children: a case-control study. J Cardiothorac Vasc Anesth 2018; 32(6): 2644-51.



Cai Y, Kosuru R, Ye X, Irwin MG, Xia Z. Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. Cell Cycle 2017; 16(19): 1765-73.

Chan LK, Ganotice FJr, Wong FKY, Lau CS, Bridges SM, Chan CHY, Chan N, Chan PWL, Chen HY, Chen JY, Chu JKP, Ho CC, Ho JMC, Lam TP, Lam VSF, Li Q, Shen JG, Tanner JA, Tso WWY, Wong AKC, Wong GTC, Wong JYH, Wong NS, Worsley A, Yu LK, Yum TP. Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning. BMC Med Edu 2017; 17(1): 221.

Cheng Y, Feng Y, Xia Z, Li X, Rong J. ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS. Biochim Biophys Acta 2017; 1862(12): 1595-1605.

Cheung CW, Wong SCS, Qiu Q, Wang XMA. Oral oxycodone for acute postoperative pain: a narrative review of clinical trials. Pain Physician 2017; 20(2S): SE33-SE52.

Cheung CW, Choi SW, Wong SSC, Lee Y, Irwin MG. Changes in prevalence, outcomes and help-seeking behavior of chronic pain in an aging population over the last decade. Pain Practice 2017; 17(5): 643-54.

Choi SW, Lam DM, Wong SCS, Shiu HC, Wang XMA, Cheung CW. Effects of Single Nucleotide Polymorphisms on Surgical and Post-surgical Opioid Requirements - A Systematic Review and Meta-analysis. Clin J Pain 2017; 33(12): 1117-30.

Gao S, Zhan L, Yang Z, Shi R, Li H, Xia Z, Yuan S, Wu QP, Wang T, Yao S. Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling. Cell Physiol Biochem 2017; 43(3): 1140-51.

Greenland KB, Bradley WPL, Chapman GA, Goulding G, Irwin MG. Emergency front-of-neck access: scalpel or cannula-and the parable of Buridan's ass. Br J Anaesth 2017; 118(6): 811-4.

Greenland KB, Bradley WPL, van Zundert A, Irwin MG. Airway assessment/management paradigm - does a spectral or a binary approach fit better? Anaesthesia 2017; 72(8): 1035-37.

Hou YY, Li Y, He SF, Song J, Yu DX, Wong GTC, Zhang Y. Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design. J Clin Anesth 2017; 41: 21-28.

Kong KFV, Jian CJ, Ji R, Irwin MG. Management of an incidental finding of right internal jugular vein agenesis. Hong Kong Med J 2017; 23(4): 414-5.

Li MJ, Li M, Liu Z, Yan B, Pan Z, Huang D, Liang Q, Ying D, Xu F, Yao H, Wang P, Kocher JA, Xia Z, Sham PC, Liu JS, Wang JJ. cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes. Genome Biol 2017; 18(1): 52.

Lu J, Yao X, Luo X, Wang Y, Chung SK, Tang H, Cheung CW, Wang X, Meng C, Li Q. Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells. Neural Regen Res 2017; 12(6): 945-52.

Qiu Q, Sun L, Wang XM, Lo ACY, Wong K, Gu P, Wong SCS, Cheung CW. Propofol produces preventive analgesia via GluN2B-containing NMDA Receptor/ERK1/2 signaling pathway in the rat model of inflammatory pain. Mol Pain 2017; 13: 1744866917737462.

Scott HB, Choi SW, Wong GTC, Irwin MG. The effect of remifentanil on propofol requirements to achieve loss of response to command vs. loss of response to pain. Anaesthesia 2017; 72(4): 479-87.

Sun LT, Tai L, Qiu Q, Mitchell R, Fleetwood-Walker S, Joosten EAJ, Cheung CW. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain 2017; 21(5): 804-14.

Tian G, LUO X, Tang C, Cheng X, Chung SK, Xia Z, Cheung CW, Guo Q. Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome. Life Sciences 2017; 170: 64-71.

Veniaminova E, Cespuglio R, Cheung CW, Umriukhin A, Markova N, Shevtsova E, Lesch KP, Anthony DC, Strekalova T. Autism-like behaviours and memory deficits result from a western diet in mice. Neural Plast 2017; 2017: 9498247.

Wang L, Zhou MT, Chen CY, Yin W, Wen DX, Cheung CW, Yang LQ, Yu WF. Increased renal clearance of rocuronium compensates for chronic loss of bile excretion, via upregulation of Oatp2. Sci Rep 2017; 7: 40438.

Wong GTC, Ang WC, Wong CLT, Choi SW. Surgical Outcome Risk Tool (SORT) validation in hepatectomy. Anaesthesia 2017; 72(10): 1287-89.

Wong SCS, Chan TCW, Cheung CW. Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice. Hong Kong Med J 2017; 23(5): 517-23.

Yao W, Li H, Han X, Chen C, Zhang Y, Tai WL, Xia Z, Hei Z. MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro. J Cell Mol Med 2017; 21(10): 2503-13.

Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z, Hei Z. SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction. Free Radic Biol Med 2017; 108: 542-53.

Ying F, Cai Y, Cai Y, Wang Y, Tang EHC. Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue. FASEB J 2017; 331(9): 4023-36.

Yuen VMY, Li BL, Cheuk DK, Leung MKM, Hui TWC, Wong IC, Lam WW, Choi SW, Irwin MG. A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children. Anaethesia 2017; 72(10): 1191-95.

Yuen VMY, Wong CHP, Wong SCS, Wong GTC. Rescue oxygenation in small infants. Anaesthesia 2017; 72(12): 1564-65.

Zhao Y, Zheng ZN, Cheung CW, Zuo ZY, Jin SQ. Transfusion of plasma collected at late phase after preconditioning reduces myocardial infarct size induced by ischemia-reperfusion in rats in vivo. Chin Med J (Engl) 2017; 130(3): 303-8.



Cao S, Liu Y, Wang H, Mao X, Chen J, Liu J, Xia Z, Zhang L, Liu X, Yu T. Ischemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts. PeerJ 2016; 4: e1706.

Cheng Y, Xia Z, Han Y, Rong J. Plant natural product formononetin protects rat cardiomyocyte H9c2 cells against oxygen glucose deprivation and reoxygenation via inhibiting ROS formation and promoting GSK-3β phosphorylation. Oxid Med Cell Longev 2016; 2016: 2060874.

Chan AC, Qiu Q, Choi SW, Wong SCS, Chan ACY, Irwin MG, Cheung CW. Effects of intra-operative total intravenous anaesthesia with Propofol versus inhalational anaesthesia with Sevoflurane on post-operatie pain in liver surgery: a retrospective case-control study. PLOS One 2016; 11: e0149753.

Luo X, Wang XMA, Xia Z, Chung SK, Cheung CW. CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain. Rev Neurosci 2016; 27(1): 83-92.

Wong SCS, Irwin MG. Peri-operative cardiac protection for non-cardiac surgery. Anaesthesia 2016; 71 S1: 29-39.

Cheung CW, Chan TCW, Chen PP, Chu MC, Chui WCM, Ho PT, Lam F, Law SW, Lee JLY, Wong SHS, Wong VKC. Opioid therapy for chronic non-cancer pain: guidelines for Hong Kong. Hong Kong Med J 2016; 22(5): 496-505.

Cheung CW. Prescriptiondrug monitoring programs needed to manage opioid use in Asia Pacific. Pain Pract 2016; 16(5): E93.

Choi SW, Cheung CW. Don't judge a book by its cover, don't judge a study by its abstract. Common statistical errors seen in medical papers. Anaesthesia 2016; 71(7): 843-5.

Choi SW, Lam DM, Irwin MG. Ghost in the machine. Hong Kong Med J 2016; 22(3): 292-3.

Choi SW, Wong GTC. It's just a standard deviation! Anaesthesia 2016; 71(8): 969-71.

Chu MT, Lee DKM, Wong DPK, Wong GTC, Yue KKM. Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals.. Metab Brain Dis 2016; 31(5): 1055-64.

Gao S, Yang Z, Shi R, Xu D, Li H, Xia Z, Wu QP, Yao S, Wang T, Yuan S. Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling. Eur J Pharmacol 2016; 779: 111-21.

Gao S, Zhu Y, Li H, Xia Z, Wu Q, Yao S, Wang T, Yuan S. Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation. Int Immunopharmaco 2016; 38: 395-401.

Huang C, Ng OTW, Ho YS, Irwin MG, Chang RCC, Wong GTC. Effect of continuous propofol infusion in rat on tau phosphorylation with or without temperature control. J Alzheimers Dis 2016; 51(1): 213-26.

Han X, Yao W, Liu Z, Li H, Zhang ZJ, Hei Z, Xia Z. Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner. Oxid Med Cell Longev 2016; 2016: 9303606.

Kandula V, Kosuru R, Li H, Yan D, Zhu Q, Lian Q, Ge RS, Xia Z, Irwin MG. Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetol 2016; 15: 44.

Li A, Yuen VMY, Dufay S, Kwok PC. Pharmacokinetics and pharmacodynamics of dexmedetomidine. Drug Dev Ind Pharm 2016; 42(12): 1917-27.

Li BL, Zhang N, Huang JX, Qiu QQ, Tian H, Ni J, Song XR, Yuen VM, Irwin MG. A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops. Anaesthesia 2016; 71(5): 522-8.

Li H, Yao W, Liu Z, Xu A, Huang Y, Ma X, Irwin MG, Xia Z. Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats.Diabetes 2016; 65(4): 942-55.

Li MJ, Liu Z, Wang P, Wong MP, Nelson MR, Kocher JPA, Yeager M, Sham PC, Chanock SJ, Xia Z, Wang J. GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res 2016; 44(D1): D869-76.

Lin J, Wang T, Li Y, Wang M, Li H, Xia Z, Irwin MG. N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats. J Diabetes Res 2016; 2016: 9213034.

Luo X, TAI WL, Sun LT, Pan Z, Xia Z, Chung SK, Cheung CW. Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 2016; 12: 1-15.

McLintic AJ, Irwin MG. Is the injury out on consensus opinion? Aaesthesia 2016; 71(3): 256-60.

Pang L, Cai Y, Tang EHC, Yan D, Li H, Irwin MG, Ma H, Xia Z, Ramoji K. COX-2 inhibition protects against hypoxia/reoxygenation-induced cardiomyocyte apoptosis via Akt-dependent enhancentment of iNOS expression. Oxid Med Cell Longev 2016; 2106: 3453059.

Pang L, Cai Y, Tang EHC, Irwin MG, Ma H, Xia Z. Prostaglandin E receptor subtype 4 signaling in the heart: role in ischemia/reperfusion injury and cardiac hypertrophy. J Diabetes Res 2016; 2016: 1324347.

Qiu Q, Choi SW, Wong SCS, Irwin MG, Cheung CW. Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis. Anaesthesia 2016; 71(10): 1222-33.

Qiao S, Mao X, Wang Y, Lei S, Liu Y, Wang T, Wong GTC, Cheung CW, Xia Z, Irwin MG. Remifentanil preconditioning reduces postischemic myocardial infarction and improves left ventricular performance via activation of the janus activated kinase-2/signal transducers and activators of transcription-3 signal pathway and subsequent inhibition of glycogen synthase kinase-3β in rats. Crit Care Med 2016; 44(3): e131-45.

Samartzis D, Bow HYC, Cheung JPY, Sham PLM, Mak KC, Cheung WY, Wong YW, Luk KDK, Cheung KMC, Law Min J. Efficacy of postoperative pain management using continuous local anesthetic infusion at the iliac crest bone raft site in patients with adolescent idiopathic scoliosis: a parallel, double-blinded, randomized controlled pilot trial. Global Spine J 2016; 6(3): 220-8.

She WH, Cheung TT, Jenkins CR, Irwin MG. Clinical applications of high-intensity focused ultrasound. Hong Kong Med J 2016; 22(4): 382-92.

Wang Y, Li H, Huang H, Liu S, Mao X, Wang S, Wong SSC, Xia Z, Irwin MG. Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling. Clin Sci (Lond) 2016; 130(10): 801-12.

Wang L, Wang T, Li H, Liu Q, Zhang Z, Xie W, Feng Y, Socorburam T, Wu G, Xia Z, Wu Q. Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice. PLoS One 2016; 11(5): e0155723.

Wang Y, Song E, Bai B, Vanhoutte PM. Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes. Pharmacol Ther 2016; 158: 91-100.

Wong GTC, Lee EYP, Irwin MG. Contrast induced nephropathy in vascular surgery. Br J Anaesth 2016; 117(S2): ii63-73.

Wong SCS, Irwin MG. Peri-operative cardiac protection for non-cardiac surgery. Anaesthesia 2016; 71(S1): 29-39.

Xia Z, Li H, Irwin MG. Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans. Br J Anaesth 2016; 117(S2):ii44-62.

Xue R, Lei S, Xia Z, Wu Y, Meng Q, Zhan L, Su W, Liu H, Xu J, Liu Z, Zhou B, Xia Z. Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways. Clin Sci (Lond) 2016; 130(5): 377-92.

Ye X, He Y, Xia Z, Wang S. Fetal descending aortic flow and heart rate monitoring with transesophageal echocardiography during maternal cardiac surgery. Can J Anaesth 2016; 63(4): 492-4.

Yu EH, Tran DH, Lam SW, Irwin MG. Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain? Anaesthesia. 2016; 71(11): 1347-62.

Zhuang H, Tian W, Li W, Zhang X, Wang J, Yang Y, Liu X, Xia Z, Feng D, Zhang L. Autophagic cell death and apoptosis jointly mediate cisatracurium besylate-induced cell injury. Int J Mol Sci 2016; 17(4): 515.



Au AHY, Choi SW, Cheung CW, Leung YY. The efficacy and clinical safety of various analgesic combinations for post-operative pain after third molar surgery: a systematic review and meta-analysis. PLoS One 2015; 10(6): e0127611.

Cheung AHK, Li LF, So VC. Leung MKM, Lui WM. Transient monoplegia and paraesthesia after an epidural blood patch for a spinal cerebrospinal fluid leak. J Clin Neurosci 2015; 22(9): 1493-5.

Cheung CW, Qiu Q, Liu J, Chu KM, Irwin MG. Intranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial. Acta Anaesthesiol Scand 2015; 59(2): 215-23.

Hung KL, Tai WL, Luo X, Xiao MW, Chung SK, Cheung CW. Targeted over-expression of astrocytic endothelin-1 attenuates neuropathic pain by up-regulating spinal excitatory amino acid transporter-2. J Mol Neurosci 2015; 57(1): 90-6.

Chow KY, Liu SE, Irwin MG. New therapy in cardioprotection. Curr Opin Anaesthesiol 2015; 28(4): 417-23.

Gan X, Xing D, Su G, Li S, Luo G, Irwin MG, Xia Z, Li H, Hei Z. Propofol attenuates small intestinal ischemia reperfusion injury through inhibiting NADPH oxidase mediated mast cell activation. Oxid Med Cell Longev 2015; 2015: 167014.

Huang C, Ho YS, Ng OT, Irwin MG, Chang RC, Wong GTC. Dexmedetomidine directly increases tau phosphorylation. J Alzheimers Dis 2015; 44(3): 839-50.

Irwin MG, Wong GTC. Remifentanil and opioid-induced cardioprotection. J Cardiothorac Vasc Anesth 2015; 29(S1): S23-6.

Jiang Y, Zhou Z, Meng QT, Sun Q, Su W, Lei S, Xia Z, Xia ZY. Ginsenoside Rb1 treatment attenuates pulmonary inflammatory cytokine release and tissue injury following intestinal ischemia reperfusion injury in mice. Oxid Med Cell Longev 2015; 2015: 843721.

Lam DM, Choi SW, Wong SCS, Irwin MG, Cheung CW. Efficacy of pregabalin in acute postoperative pain under different surgical categories: a meta-analysis. Medicine 2015; 94(46): e1944.

Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang T, Xia Z. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med 2015; 84: 311-21.

Li S, Xu J, Yao W, Li H, Liu Q, Xiao F, Irwin MG, Xia Z, Ruan W. Sevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathway. Biochem Biophys Res Commun 2015; 460(3): 879-86.

Liman S, Cheung CW, Wong K, Tai WL, Qiu Q, Ng JKF, Choi SW, Irwin MG. Preventive treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postichaemia pain model. Oxid Med Cell Longev 2015; 2015: 380403.

Liu B, Huang WH, Xiao X, Yu Y, Ma S, Xia Z. Neuroprotective effect of ulinastatin on spinal cord ischemia-reperfusion injury in rabbits. Oxid Med Cell Longev 2015; 2015: 624819.

Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GTC, Irwin MG, Xia Z. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond) 2015; 129(4): 331-44.

Low SJ, Wong SCS, Qiu Q, Lee Y, Chan TCW, Irwin MG, Cheung CW. An audit of changes in outcomes of acute pain service: evolution over the last 2 decades. Medicine 2015; 94(40): e1673.

Luo C, Yuan D, Li X, Yao W, Luo G, Chi X, Li H, Irwin MG, Xia Z, Hei Z. Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexion 32. Anesthesiology 2015; 122(1): 72-86.

Tian Y, Li H, Liu P, Xu JM, Irwin MG, Xia Z, Tian G. Captopril pretreatment produces an additive cardioprotection to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans. Mediators Inflamm 2015; 2015: 819232.

Tsui PY, Cheung CW, Lee Y, Leung SWS, Ng JKF. The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial. BMC Anesthesiol 2015; 15: 80.

Wang DL, Zhan L, Zhang J, Xia Z. Nurses’ blame attributions towards different types of cancer: a cross-sectional study. Int J Nurs Stud2015; 52(10): 1600-6.

Wang XM, Walitt B, Saligan L, Tiwari AF, Cheung CW, Zhang ZJ. Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy. Cytokine 2015; 72(1): 86-96.

Xia R, Xu J, Yin H, Wu HZ, Xia Z, Zuo D, Xia ZY, Zhang LP, LI H, Xiao X. Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients. Mediators Inflamm 2015; 2015: 238041.

Xia Z, Chen Y, Fan Q, Xue MZ, Liu KX. Oxidative stress-mediated reperfusion injury 2014. Oxid Med Cell Longev 2015; 2015: 689416.

Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med 2015; 84: 311-21.

Yu HP, Chaudry IH, Choudhry MA, Hsing CH, Liu FC, Xia Z. Inflammatory response to traumatic injury: clinical and animal researches in inflammation. Mediators Inflamm 2015; 2015: 729637.

Zhou M, Bao Y, Li H, Pan Y, Shu L, Xia Z, Wu D, Lam KSL, Vanhoutte PM, Xu A, Jia W, Hoo RLC. Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction. Clin Sci (Lond) 2015; 129(7): 547-59.



Cheung CW, Qiu Q, Choi SW, Moore BJ, Goucke CR, Irwin MG. Chronic opioid therapy for chronic non-cancer pain: a review and comparison of treatment guidelines. Pain Physician 2014; 17(5): 401-14.

Cheung CW, Qiu Q, Ying AC, Choi SW, Law WL Irwin MG. The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery. Anaesthesia 2014; 69(11): 1214-21.

Cheung TT, Poon RTP, Jenkins CR, Chu SKF, Chok KSH, Chan ACY, Tsang SHY, Dai WC, Yau TCC, Chan SC, Fan ST, Lo CM. Survival analysis of high-intensity focused ultrasound therapy vs. transarterial chemoembolization for unresectable hepatocellular carcinomas. Liver Int 2014; 34(6): e136-43.

Feng L, Liu TT, Ye DW, Qiu Q, Xiang HB, Cheung CW. Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: A virally mediated transsynaptic tracing study in transgenic mouse model. Epilepsy Behav 2014; 31C: 114-6.

Greenland KB, Irwin MG. Airway management - 'spinning silk from cocoons' (-Chinese idiom). Anaesthesia 2014; 69(4): 296-00.

Hung VKL, Tai WL, Qiu Q, Luo X, Wong KL, Chung SK, Cheung CW. Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor. Mol Cell Nurosci 2014; 60: 26-35.

Irwin MG, Gan TJ. Volume therapy with hydroxyethyl starches: are we throwing the anaesthesia baby out with the intensive care unit bathwater? Anesth Analg 2014; 119(3): 737-9.

Li MJ, Wang LY, Xia Z, Wong MP, Sham PC, Wang JW. dbPSHP: a database of recent positive selection across human populations. Nucleic Acids Res 2014; 42: D910-6.

Luo X, Tai WL, Sun LT, Qiu Q, Xia Z, Chung SK, Cheung CW. Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice. PLoS One 2014; 9(8): e104860.

Li BL, Yuen VMY, Song XR, Ye J, Ni J, Huang JX, Irwin MG. Intranasal dexmedetomidine following failed chloral hydrate sedation in children. Anaesthesia 2014; 69(3): 240-4.

Li T, Li J, Li H, Xia Z, Shi X, Li X, Liu Y. [Effects of hypertonic sodium chloride hydroxyethyl starch solution on cerebral vasospasm following subarachnoid hemorrhage and its mechanism]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2014; 26(8): 589-93.

Liu Y, Yang L, Tao K, Vizcaychipi MP, Lloyd DM, Sun X, Irwin MG. Ma D, Yu W. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol 2014; 14(1): 12.

Lu Y, Wong GTC, Zhang Y, Hu J, Dong C. Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine. Kaohsiung J Med Sci 2014; 30(2): 68-72.

Mei W, Li M, Yu Y, Cheung CW, Cao F, Nie B, Zhang Z, Wang P, Tian Y. Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study. Eur J Pain 2014; 18(2): 238-48.

Tran HDD, Wong GTC, Chee YE, Irwin MG. Effectiveness and safety of erythropoiesis-stimulating agent use in the perioperative period. Expert Opin Biol Ther 2014; 14(1): 51-61.

Wen SH, Ling YH, Liu WF, Qiu YX, Li YS, Wu Y, Shen JT, Xia Z, Liu KX. Role of 15-F2-isoprostane in intestinal injury induced by intestinal ischemia/reperfusion in rats. Free Radic Res 2014; 48(8):907-18.

Wong CFP, Yuen VMY, Wong GTC, To JYT, Irwin MG. Time to adequate oxygenation following ventilation using the Enk oxygen flow modulator versus a jet ventilator via needle criothyrotomy in rabbits. Paediatr Anaesth 2014; 24(2): 208-13.

Wong K, Wu YR, Cheng KS, Chan P, Cheung CW, Lu DY, Su TH, Liu ZM, Leung YM. Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes. Pharmacol Rep 2014; 66(6): 1106-13.

Xia Z, Chen Y, Fan Q, Xue M. Oxidative stress-mediated reperfusion injury: mechanism and therapies. Oxid Med Cell Longev 2014; 2014: 373081.

Xu J, Li H, Irwin MG, Xia ZY, MAO X, Lei S, Wong GTC, Hung V, Cheung CW, Fang X, Clanachan AS, Xia Z. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats. Crit Care Med 2014; 42(8): e583-94.

Yao W, Luo G, Zhu G, Chi X, Zhang A, Xia Z, Hei Z. Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. Oxid Med Cell Longev 2014; 2014: 258567.



Chan WW, Wong GTC, Irwin MG. Perioperative statin therapy. Expert Opin in Pharmacother 2013; 14: 831-42.

Cheung TT, Fan ST, Chan SC, Chok KSH, Chu SKF, Jenkins CR, Lo CLR, Fung JYY, Chan ACY, Sharr WW, Tsang SHY, Dai WC, Poon RTP, Lo CM. High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients. World J Gastroenterol 2013; 19(20): 3083-9.

Cheung TT, Fan ST, Chu SKF, Jenkins CR, Chok KSH, Tsang SHY, Dai WC, Chan ACY, Chan SC. Yau TCC, Poon RTP, Lo CM. Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma. HPB (Oxford) 2013; 15(8): 567-73.

Cheung TT, Poon RTP, Yuen WK, Chok KSH, Jenkins CR, Chan SC, Fan ST, Lo CM. Long-term survival analysis of pure laparoscopic versus open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a single-center experience. Ann Surg 2013; 257(3): 506-11.

Chi X, Zhang A, Luo G, Xia H, Zhu G, Hei Z, Liu X, Wei J, Xia Z. Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model. Pulm Pharmacol Ther 2013; 26(3): 380-7.

Cho SS, Rudloff I, Berger PJ, Irwin MG, Nold MF, Cheng W, Nold-Perty CA. Remifentanil ameliorates intestinal ischemia-reperfusion injury. BMC Gastroenterol 2013; 13: 69.

Li HB, Irwin MG, Tao M, Li Y, Zhang L, Xia Z. Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes. J Diabetes Metab 2013; 4(3): 1000247.

Li HB, Liu Z, Wang JW, Wong GTC, Cheung CW, Zhang L, Chen C, Xia Z, Irwin MG. Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats. Cardiovasc Diabetol 2013; 12(1): 133.

Li MJ, Wang Y, Xia Z, Sham PC, Wang JW. GWAS3D: detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications. Nucleic Acids Res 2013; 41(WSI): W150-8.

Li L, Zhang QG, Lai LY, Wen XJ, Zheng T, Cheung CW, Zhou SQ, Xu SY. Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells. Oxid Med Cell Longev 2013; 2013: 159864.

Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng JKF, Lau WB, Ma XL, Rodrigues B, Irwin MG, Xia Z. Hyperglycemia-Induced protein kinase C beta2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. Diabetes 2013; 62(7): 2318-28.

Leung KMM, Irwin MG. Perioperative cardioprotection. F1000Prime Rep 2013; 5:7.

Liao XL, Hu XX, Chang FJ, Yuan FY, Ci HB, Wu JY, Xu Z, Wang ZP, Zhang X, Xia Z, Ou JS. A simple modification results in greater success in the model of coronary artery ligation and myocardial ischemia in mice. J Cardiovasc Pharmacol 2013; 61(5): 430-6.

Liu J, Hou J, Xia ZY, Zeng W, Wang X, Li R, Ke C, Xu J, Lei S, Xia Z. Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes. Free Radic Res 2013; 47(5): 386-93.

Mao X, Wang T, Liu Y, Irwin MG, Ou J, Liao XL, Gao X, Xu Y, Ng JKF, Vanhoutte PMGR, Xia Z. N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats. PLoS ONE 2013; 8(7): e68949.

Qin J, Li MJ, Wang P, Wong NS, Wong MP, Xia Z, Tsao GSW, Zhang MQ, Wang JW. ProteoMirExpress: inferring MicroRNA and Protein-centered regulatory networks from high-throughput proteomic and mRNA expression data. Mol Cell Proteomics 2013; 12(11): 3379-87.

Tai LW, Hung VK, Mei W, Qiu Q, Chung S, Cheung CW. Effects of repeated central administration of endothelin type A receptor antagonist on the development of neuropathic pain in rat. BioMed Res Int 2013, 2013: 529871.

Wang T, Yao S, Xia Z, Irwin MG. Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning. Front Med 2013; 7(3): 301-5.

Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GTC, Vanhoutte PMGR, Irwin MG, Xia Z. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med 2013; 63: 291-03.

Wang Y, Zhu Q, Luo C, Zhang A, Hei Z, Su G, Xia Z, Irwin MG. Dual effects of bilirubin on the proliferation of rat renal NRK52E cells and ITS association with gap junctions. Dose-Response 2013; 11(2): 220-37.

Wong GTC, Irwin MG. Poisoning with illicit substances: toxicology for the anaesthetist. Anaesthesia 2013; 68(S1): 117-24.

Wu H, Lei S, Yuan J, Liu X, Zhang D, Gu X, Zhang L, Xia Z. Ischemic postconditioning downregulates Egr-1 expression and attenuates postischemic pulmonary inflammatory cytokine release and tissue injury in rats. J Surg Res 2013; 181(2): 204-12.

Xu J, Lei S, Liu Y, Gao X, Irwin MG, Xia ZY, Hei Z, Gan X, Wang T, Xia Z. Antioxidant N-acetylcysteine attenuates the reduction of brg1 protein expression in the myocardium of type 1 diabetic rats. J Diabetes Res 2013; 2013: 716219.

Ye DW, Ding DF, Liu TT, Tian XB, Liu C, Li RC, Xiang HB, Cheung CW. The optimal segment for spinal cord stimulation in intractable epilepsy: A virally mediated transsynaptic tracing study in spinally transected transgenic mice. Epilepsy Behav 2013; 29(3): 599-01.


Alaali HH, Irwin MG. Anaesthesia for urologial surgery. Anaesth Intensive Care Med 2012; 13 (7): 343-7.

Cheung CW, Choi WWS, Leung MYY, Lui F, Ng JKF, Ho AMH, Irwin MG. A double blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia. J Oral Maxillofac Surg 2012; 70(1): 25-30.

Cheung JPY, Ng JLM, Chow W, To MKT. Fat embolism syndrome in a child with dystonia musculorum deformans. BMJ Case Rep 2012; 2012: bcr1220115466.

Cheung TT, Chu FS, Jenkins CR, Tsang DS, Chok KSH, Chan ACY, Yau TCC, Chan SC, Poon RTP, Lo CM, Fan ST. Tolerance of high-intensity focused ultrasound ablation in patients with hepatocellular carcinoma. World J Surg 2012; 36(10): 2420-7.

Gao X, Xu Y, Xu B, Liu Y, Cai J, Liu HM, Lei S, Zhong YQ, Irwin MG, Xia Z. Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes. Diabetes Metab Res Rev 2012; 28(5): 409-17.

Ho AMH, Dion PW, Yeung JHH, Joynt GM, Lee A, Ng CSH, Chang A, So FL, Cheung CW. Simulation of survivorship bias in observational studies on plasma to red blood cells ratios in massive transfusion in trauma. Br J Surg 2012; 99(S1): 132-9.

Ho AMH, Dion PW, Yeung JHH, Holcomb JB, Critchley LAH, Ng CSH, Karmakar MK, Cheung CW, Rainer TH. Prevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusion. Anesthesiology 2012; 116(3): 716-28.

Ho AMH, Ricci CJ, Ng CS, Critchley LA, Ho AK, Karmakar MK, Cheung CW, Ng SK. The medial-transverse approach for internal jugular vein cannulation: an example of lateral thinking. J Emerg Med 2012; 42(2): 174-7.

Huang P, Liu D, Gan X, Zhang R, Gao W, Xia Z, Hei Z. Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats. Injury 2012; 43(8): 1250-6.

Hung KL, Chan MM, Chen AYS, Tai LW, Chung SK, Cheung CW. Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection. Life Sci 2012; 91(13-14): 618-22.

Irwin MG, Wong SSC. Anaesthesia and minimally invasive surgery. Anaesth Int Care Med 2012; 13(2): 48-51.

Irwin MG, Wong SSC. Anaesthesia for fractured neck of femur. Anaesth Int Care Med 2012; 13(3): 94-8.

Lei S, Liu Y, Liu H, Yu H, Wang H, Xia Z. Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats. Yonsei Med J 2012; 53(2): 294-303.

Li T, Wu W, You Z, Zhou R, Li Q, Zhu D, Li H, Xiang X, Irwin MG, Xia Z. Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass. Eur J Pharmacol 2012; 677(1-3): 138-46.

Liu KX, Xia Z. Potential synergy of antioxidant N-acetylcysteine and insulin in restoring sevoflurane postconditioning cardioprotection in diabetes. Anesthesiology 2012; 116(2):488-9.

Liu Y, Lei S, Gao X, Mao X, Wang T, Wong GT, Vanhoutte PM, Irwin MG, Xia Z. PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Clin Sci (Lond) 2012; 122(4):161-73.

Lu DY, Chang CS, Yeh WL, Tang CH, Cheung CW, Leung Y, Liu JF, Wong KL. The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine 2012; 19(12): 1093-100.

Ng FY, Ng JKF, Chiu PKY, Yan CH, Chan CW. Multimodal periarticular injection vs continuous femoral nerve block after total knee arthroplasty: a prospective, crossover, randomized clinical trial. J Arthroplasty 2012; 27(6): 1234-8.

Poon TCJ, Cheung CW, Fan JKM, Lo OSH, Law WL. Single-incision versus conventional laparoscopic colectomy for colonic neosplasm: arandomized,controlled trial. Surg Endosc 2012; 26(10): 2729-34.

Sharma A, Lawmin J, Irwin MG. Anaesthesia for spinal surgery. Anaesth Int Care Med 2012; 13(3): 99-101.

Wang M, Peng J, Wang R, Zhao L, Xia Z. TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res 2012; 173(1): 153-60.

Wang Y, Wong GTC. Man K, Irwin MG. Pretreatment with intrathecal or intravenous morphine attenuates hepatic ischaemia-reperfusion injury in normal and cirrhotic rat liver. Br J Anaesth 2012; 109(4): 529-39.

Wong GTC, Irwin MG. EVAR fever: minimally invasive, maximally inclusive? Anaesthesia 2012; 67(4): 351-4.

Wong GTC, Lu Y, Mei B, Xia Z, Irwin MG. Cardioprotection from remote preconditioning involves spinal opioid receptor activation. Life Sci 2012; 91(17-18): 860-5.

Wong GTC, Lu Y, Xia Z, Irwin MG. Intrathecal morphine remotely preconditions the heart via a neural pathway. J Cardiovasc Pharmacol 2012; 60(2): 172-8.

Wong S, Irwin MG. Procedures under tourniquet. Anaesth Int Care Med 2012; 13(3): 85-8.

Wylie SJ, Wong GTC, Chan YC, Irwin MG. Endovascular aneurysm repair: a perioperative perspective. Acta Anaesthesiol Scand 2012; 56(8): 941-9.

Yuen VMY, Hui TWC, Irwin MG, Yao TJ, Chan L, Wong GL, Shahnaz Hasan M, Shariffuddin II. A randomised comparison of two intranasal dexmedetomidine doses for premedication in children. Anaesthesia 2012; 67(11): 1210-6.

Zhang YM, Wang CY, Zheng FC, Gao FF, Chen YC, Huang ZQ, Xia Z, Irwin MG, Li WQ, Liu XP, Zheng YS, Xu H, Shi GG. Effects of N-n-butyl haloperidol iodide on the rat myocardial sarcoplasmic reticulum Ca(2+)-ATPase during ischemia/reperfusion. Biochem Biophys Res Commun 2012; 425(2): 426-30.



Chan BKB, Tam LK, Chung YF, Wat CY, Tsui SL, Cheung CW. Opioids in Chronic non-cancer pain. Expert Opin Pharmacother 2011; 12(5): 705-20.

Chan SC, Lo CM, Ng KKC, Ng IOL, Yong BH, Fan ST. Portal inflow and pressure changes in right liver living donor liver transplantation including the middle hepatic vein. Liver Transpl 2011; 17(2): 115-21.

Cheung CW, Ng JKF, Liu J, Yuen VMY, Ho MHA, Irwin MG. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth 2011; 107(3): 430-7.

Cheung CW, Ng JKF, Choi WWS, Chiu WK, Ying CLA, Irwin MG. Evaluation of the analgesic efficacy of local dexmedetomidine application. Clin J Pain 2011; 27(5): 377-82.

Chou CW, Wong GTC, Lim G, McCabe MF, Wang S, Irwin MG, Mao J. Peripheral nerve injury alters the expression of NF-κB in the rat's hippocampus,Brain Res. 2011, 1378: 66-71.

Chou CW, Wong GTC, Lim G, Wang S, Irwin MG, Mao J. Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury. J Pain 2011; 12(1): 13-21.

Fan Q, Yang XC, Liu Y, Wang LF, Liu SH, Ge YG, Chen ML, Wang W, Zhang LK, Irwin MG, Xia Z. Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans. Clin Sci (Lond) 2011; 120(6): 251-61.

Huang SM, Cheung CW, Chang CS, Tang CH, Liu JF, Lin YH, Chen JH, Ko SH, Wong K, Lu DY. Phloroglucional derivative MCPP induces cell apoptosis in human colon cancer. J Cell Biochem 2011; 112(2): 643-52.

Huang Z, Zhong XW, Irwin MG, Ji S, Liu Y, Xia ZY, Finegan BA, Xia Z. Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients. Clin Sci (Lond) 2011; 121(2): 57-69.

Hung IFN, To KKW, Lee CK, Lee KL, Chan K, Yan WW, Liu R, Watt CL, Chan WM, Lai KY, Koo CK, Buckley T, Chow FL, Wong KK, Chan HS, Ching CK, Tang BSF, Lau CY, Li WS, Liu SH, Chan KH, Lin CK, Yuen KY. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection,Clin Infect Dis. 2011, 52(4): 447-56.

Liu HM, Liu KX, Cheng MH, Liu Y, Lei S, Irwin MG, Xia Z. Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts. J Surg Res 2011; 168(1): 18-26.

Lu Y, Wong GTC, Xia Z, Irwin MG. Interaction between spinal opioid and adenosine receptors in the remote cardiac preconditioning effect of intrathecal morphine. J Cardiothorac Vasc Anesth 2011; 25(3): 444-8.

Lui F, Ng JKF. Adjuvant analgesics in acute pain. Expert Opin Pharmacother 2011; 12(3): 363-85.

Ng JKF, Cheung CW, Lee Y. Low dose desmopressin improves hypothermia induced impairment of primary haemostasis in healthy volunteers. Anaesthesia 2011; 66(11): 999-1005.

Ren HM, Yang LQ, Liu ZQ, Chen CY, Cheung CW, Tao KM, et al. In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice. BMC Gastroenterol 2011; 11: 144.

Tse EYW, Cheung WY, Ng JKF, Luk KDK. Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery. J Bone Joint Surg Am 2011; 93(13): 1268-77.

Wang T, Qiao S, Lei S, Liu Y, Ng JKF, Xu A, Lam KSL, Irwin MG, Xia Z. N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats. PLoS One 2011; 6(8): e23967.

Wei L, Le XC, Xia Z, Han Y, Rong J. Pharmacological induction of leukotriene B4 12-hydroxydehydrogenase in human neutrophils and its potential in the treatment of myocardial injury, Journal of Heart Disease. Cardiology Online 2011; 8: 66.

Wu H, Wu W, Sun H, Qin GW, Wang HB, Wang P, Yalamanchili HK, Wang JJ, Tse HF, Lau CP, Vanhoutte PMGR, Li GR. Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. J Mol Cell Cardiol 2011; 51(6): 966-73.

Xia Z, Vanhoutte PMGR. Nitric oxide and protection against cardiac ischemia. Curr Pharm Des 2011; 17(18): 1774-82.

Xu B, Gao X, Xu J, Lei S, Xia ZY, Xu Y, Xia Z. Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1. J Surg Res 2011; 166(2): e157-64.

Yang LQ, Tao KM, Liu YT, Cheung CW, Wong GTC, Lv H, Song JG, Wu FX, Yu WF. Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression. Anesthesiology 2011; 114(5): 1036-47.

Zhang Y, Lu Y, Mei B, Zhou YM, Chen ZW, Wong TM. Intracerebroventricular administration of morphone confers remote cardioprotecion - role of opioid receptors and calmodulin. Eur J Pharmacol 2011; 656(1-3): 74-80.

Zhu XH, Yuan HJ, Wu YN, Kang Y, Jiao JJ, Gao WZ, Liu YX, Lou JS, Xia Z. Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats. Free Radic Res 2011; 45(2): 201-10.



Chan AK, Cheung CW, Chong YK. Alpha-2 agonists in acute pain management. Expert Opin Pharmacother 2010; 11(17): 2849-68.

Chan SC, Lo CM, Yong BH, Tsui WJC, Ng KKC, Fan ST. Paired donor interchange to avoid ABO-incompatible living donor liver transplantation. Liver Transpl 2010; 16(4): 478-81.

Cheng TH, Leung YM, Cheung CW, Chen CH, Chen YL, Wong KL. Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts. Anesthesiology 2010; 112(1): 108-18.

Chiang JCS, Irwin MG, Hussain A, Tang YK, Hiong YT. Anaesthesia for emergency caesarean section in a patient with large anterior mediastinal tumour presenting as intrathoracic airway compression and superior vena cava obstruction. Case Report Med 2010; 2010: 708481.

Greenland KB, Edwards MJ, Hutton NJ, Challis VJ, Irwin MG, Sleigh JW. Changes in airway configuration with different head and neck positions using magnetic resonance imaging of normal airways: a new concept with possible clinical applications. Br J Anaesth 2010; 105(5): 683-90.

Guo Y, Wu XQ, Zhang C, Liao ZX, Wu Y, Xia Z, Wang H. Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. Clin Exp Pharmacol Physiol 2010; 37(12): 1107-13.

Ho AMH, Dion PW, Yeung YHH, Ng CSH, Karmakar MK, Crtichley LAH, Rainer TR, Cheung CW, Tay BA. Fresh-frozen plasma transfusion strategy in trauma with massive and ongoing bleeding. Common (sense) and sensibility. Resuscitation 2010; 81(9): 1079-81.

Jiang L, Wong GTC, Lu Y, Xia Z, Irwin MG. Remote pharmacological post-conditioning by intrathecal morphine: cardiac protection from spinal opioid receptor activation. Acta Anaesthesiol Scand 2010; 54(9): 1097-04.

Lau TW, Leung FKL, Siu DCW, Wong GTC, Luk KDK. Geriatric hip fracture clinical pathway: the Hong Kong experience. Osteoporosis Int. 2010, 21(S4): S627-36.

Li YS, Wang ZX, Li C, Xu M, Li Y, Huang WQ, Xia Z, Liu KX. Proteomics of ischemia/reperfusion injury in rat intestine with and without ischemic postconditioning. J Surg Res. 2010, 164(1): e173-80.

Liang S, Irwin MG. Review of anesthesia for middle ear surgery. Anesthesiol Clin 2010; 28(3): 519-28.

Liu KX, Li C, Li YS, Yuan BL, Xu M, Xia Z, Huang WQ. Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase. Proteomics 2010; 10(24): 4463-75.

Lu DY, Leung YM, Cheung CW, Chen YR, Wong K. Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells. Biochem Pharm 2010; 80(8): 1201-9.

Poon JTC, Cheng SWK, Wong SJ, Ting ACW. Prevalence of abdominal aortic aneurysm in Chinese patients with severe coronary artery disease. ANZ J Surg 2010; 80(9): 630-3.

Siu DCW, Sun NCH, Lau TW, Yiu KH, Leung FKL, Tse HF. Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective. Osteoporos Int 2010; 21(S4): S587-91.

Tan G, Irwin MG. Recent advances in using propofol by non-anesthesiologists. F1000 Med Rep 2010; 2: 79.

Wong ESW, Man RYK, Vanhoutte PM, Ng KFJ. Dexmedetomidine induces both relaxations and contractions, via different α2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. J Pharmacol Exp Ther 2010; 335(3): 659-64

Wong GTC, Irwin MG. Pretreatment time with norbinaltorphimine [Letter]. Anesth Analg 2010; 110(4): 1243-4.

Wong GTC, Jiang LL, Irwin MG. Activation of central opioid receptors induces cardioprotection against ischemia-reperfusion injury. Anesth Analg 2010; 111(1): 24-8.

Wong GTC, Li R, Jiang L, Irwin MG. Remifentanil post-conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation. Acta Anaesthesiol Scand 2010; 54(4): 510-8.

Wong GTC, Sun NCH. Providing perioperative care for patients with hip fractures. Osteoporos Int 2010; 21(S4): S547-53.

Wong GTC, Huang Z, Ji S, Irwin MG. Remifentanil reduces the release of biochemical markers of myocardial damage after coronary artery bypass surgery: a randomized trial. J Cardiothorac Vasc Anesth 2010; 24(5): 790-6.

Xia Z, Luo T, Liu H, Wang F, Xia ZY, Irwin MG, Vanhoutte PMGR. L-arginine enchances nitrative stress and exacerbates tumor necrosis factor-α toxicity to human endothelial cells in culture: prevention by propofol. J Cardiovasc Pharmacol 2010; 55(4): 358-67.

Yang LQ, Tao KM, Cheung CW, Liu YT, Tao Y, Wu FX, Yu WF. The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients. Anaesthesia 2010; 65(11): 1094-00.

Yang LQ, Song JC, Irwin MG, Song JG, Sun YM, Yu WF. A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice. Acta Aaesthesiol Scand 2010; 54(7): 871-7.

Yuen VMY, Hui TWC, Irwin MG, Yao TJ, Wong GLS, Yuen MK. Optimal timing for the administration of intranasal dexmedetomidine for premedication in children. Anaesthesia 2010; 65(9): 922-9.

Zhang JF, Yang JP, Wang GH, Xia Z, Duan SZ, Wu Y. Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion. Diabetes Metab Res Rev 2010; 26(1): 59-70.


Chan AC, Fan ST, Lo CM, Liu CL, Chan SC, Ng KK, Yong BH, Chiu A, Lam BK. Liver transplantation for acute-on-chronic liver failure. Hepatol Int 2009; 3(4): 571-81.

Cheung CW, Ying CL, Lee LH, Tsang SF, Tsui SL, Irwin MG. An audit of postoperative intravenous patient-controlled analgesia with morphine: evolution over the last decade. Eur J Pain 2009; 13(5): 464-71.

Choi WS, Irwin MG, Samman N. The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial. J Oral Maxillofac Surg 2009; 67(1): 125-33.

Chung PHY, Wong KKY, Tam PKH, Chan KL, Ng KKC, Chan SC, Hui TWC, Yong BH, Fan ST, Lo CM. Split graft liver transplant for paediatric patients in Hong Kong. HK J Paediatr (new series) 2009; 14(3): 181-5.

Irwin MG, Trinh TP, Yao CL. Occupational exposure to anaesthetic gases: a role for TIVA. Expert Opin Drug Saf 2009; 8(4): 473-83.

Kong VKF, Irwin MG. Adjuvant analgesics in neuropathic pain. Eur J Anaesthesiol 2009; 26(2): 96-100.

Li R, Wong GTC, Wong TM, Zhang Y, Xia Z, Irwin MG. Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa and mu opioid receptors in rats. Anesth Analg 2009, 108(1): 23-9.

Liu KX, Li YS, Huang WQ, Chen SQ, Wang ZX, Liu JX, Xia Z. Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med 2009; 35(5): 933-42.

Ng JKF, Lawmin JC, Tsang SF, Tang WM, Chiu PKY. The value of a single preoperative PFA-100® measurement in assessing the risk of bleeding in patients taking cyclooxygenase inhibitors and undergoing total knee replacement. Br J Anaesth 2009; 102(6): 779-84.

Poon CC, Irwin MG. Anaesthesia for deep brain stimulation and in patients with implanted neurostimulator devices. Br J Anaesth 2009; 103(2): 152-65.

Tam LK, Ng JKF. The role of desmopressin in a patient with severe coagulopathy aggravated by mild therapeutic hypothermia [Letter]. Resuscitation 2009; 80(10): 1216-7.

Tam MK, Irwin MG, Tse ML, Lui YW, Law KI, Ng PW. Prolonged myoclonus after a single bolus dose of propofol. Anaesthesia 2009; 64(11): 1254-7.

Tsai GY, Cui JZ, Syed H, Xia Z, Ozerdem U, McNeill JH, Matsubara JA. Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats. Clin Experiment Ophthalmol 2009; 37(2): 223-31.

Wang F, Liu HM, Irwin MG, Xia ZY, Huang Z, Ouyang J, Xia Z. Role of protein kinase C β2 activation in TNF-α-induced human vascular endothelial cell apoptosis. Can J Physiol Pharmacol 2009; 87(3): 221-9.

Xia Z, Irwin MG. Esmolol may abolish volatile anesthetic-induced postconditioning by scavenging reactive oxygen species. Anesthesiology 2009; 111(4): 924-5.

Zhang Y, Irwin MG, Li R, Chen ZW, Wong TM. Effects of remifentanil on intracellular Ca2+ and its transients induced by electrical stimulation and caffeine in rat ventricuar myocytes. Chinese Med J 2009; 122(12): 1439-43.


Chan YC, Cheng SWK, Irwin MG. Perioperative use of statins in noncardiac surgery. Vasc Health Risk Manag 2008; 4(1): 75-81.

Cheung CW, Irwin MG, Chiu WK, Ying CLA. A study to assess the value of bispectral analysis in intravenous sedation with midazolam during third molar surgery under local anaesthesia. Anaesthesia 2008; 63(12): 1302-8.

Chia AC, Irwin MG, Lee PW, Lee TH, Man SF. Comparison of stress in anaesthetic trainees between Hong Kong and Victoria. Anaesth Intensive Care 2008; 36(6): 855-62.

Fung NY, Hu Y, Irwin MG, Chow BE, Yuen VMY. Comparison between sevoflurane/remifentanil and propofol/remifentanil anaesthesia in providing conditions for somatosensory evoked potential monitoring during scoliosis corrective surgery. Anaesth Intensive Care 2008; 36(3): 779-85.

Greenland KB, Eley V, Edwards MJ, Allen P, Irwin MG. The origins of sniffing position and the three axes alignment theory for direct laryngoscopy. Anaesth Intensive Care 2008; 36(S1): 23-7.

Ho EYW, Leung GPH, Man RYK, Vanhoutte PM, Ng JKF. Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature. FASEB J 2008; 22: 914.10.

Lee LHY, Irwin MG, Yao TJ, Yuen MK, Cheung CW. Timing of intraoperative parecoxib analgesia in colorectal surgery. Acute Pain 2008; 10(3-4): 123-30.

Liu KX, Huang WQ, Li YS, Irwin MG, Xia Z. Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats. Anesth Analg 2008; 107(6): 1884-91.

Ng JKF, Leung SWS, Man RYK, Vanhoutte PM. C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary artery. FASEB J 2008; 22: 914.3.

Ng JKF, Tsang SF, Leung SWS, Tang WM, Chiu PKY. Coagulation, blood loss and platelet activation during isoflurane or sevolfurane anaesthesia. Anesthesiology 2008; 109: A1619.

Ng JKF, Lawmin JC, Li CCF, Tsang SF, Tang WM, Chiu PKY. Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac. J Arthroplasty 2008; 23(3): 424-30.

Ng JKF, Leung SWS, Man RYK, Vanhoutte PM. Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins. Acta Pharmacol Sin 2008; 29(12): 1419-24.

Ng WWH, Keung WWY, Xu YC, Ng JKF, Leung GPH, Vanhoutte PM, Choy PC, Man RYK. Genistein potentiates protein kinase A activity in porcine coronary artery. Mol Cell Biochem. 2008; 311(1-2): 37-44.

Nie R, Zhong X, Xia Z. Antioxidant intervention before and during myocardial ischemia may exacerbate post-ischemic myocardial dysfunction: relationship with endothelin-1 production. Med Hypotheses 2008; 70(1): 194-5.

Wong GLS, Yong BH, Young KK, Lau LS, Cheng KL, Man JSF, Irwin MG. Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation. Liver Transpl 2008; 14(7): 1038-43.

Xia Z. Role of hydrogen peroxide in propofol restoration of microvacular function impaired by high glucose. Anesthesiology 2008; 109(5): 930.

Yao CL, Trinh TP, Wong GTC, Irwin MG. Anaesthesia for high intensity focused ultrasound (HIFU) therapy. Anaesthesia 2008; 63(8): 865-72.

Ying CLA, Tsang SF, Ng JKF. The potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100? Resuscitation 2008; 76(1): 129-33.

Yuen VMY, Hui TWC, Irwin MG, Yuen MK. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. Anesth Analg 2008; 106(6): 1715-21.

Cheung CW, Ying CLA, Chiu WK, Wong GTC, Ng JKF, Irwin MG. A comparison of dexmedetomidine and midazolam for sedation in third molar surgery. Anaesthesia 2007; 62(11): 1132-8.

Diemunsch P, Gan TJ, Philip BK, Girao MJ. Eberhart L, Irwin MG, Pueyo J, Lawson FC. Single-dose aprepitant versus ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 2007; 99(2): 202-11.

Greenland K.B., Liu G., Tan H., Edwards M, Irwin MG. Comparison of the Levitan FPS ScopeTMand the single-use bougie for simulated difficult intubation in anaesthetised patients. Anaesthesia 2007; 62(5): 509-15.

Greenland K.B., Tsui D., Goodyear P. and Irwin MG. Personal protection equipment for biological hazards: does it affect tracheal intubation performance? Resuscitation 2007; 74(1): 119-26.

Guo CXX, Irwin MG, Cheung KMC, Chan D. An effective dose of Valdecoxib in experimental mouse models of pain. Methods Find Exp Clin Pharmacol 2007; 29(6): 383-8.

Kong VKF, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth 2007; 99(6): 775-86.

Kong VKF, Yuen MK, Irwin MG. Perioperative ultrasonography: ultrasound and vascular cannulation. CPD Anaesthesia 2007; 9(1): 3-9.

Yu CK, Li YH, Wong GTC, Wong TM, Irwin MG. Remifentanil preconditioning confers delayed cardioprotection in the rat. Br J Anaesth 2007; 99(5): 632-8.

Nie R, Xia R, Zhong X, Xia Z. Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat. Can J Physiol Pharmacol. 2007, 85(10):1012-9.

Wong GTC, Jenkins CR, Yao TJ, Irwin MG. A trend toward improved learning of cardiovascular pathophysiology in medical students from using a human patient simulator: results of a pilot study,Advan in Physiol Edu. 2007, 31(4): 372.

Wong GTC, Irwin MG. Contrast-induced nephropathy. Br J Anaesth 2007; 99(4): 474-83.

Wong GTC, Yuen VMY, Chow BFM, Irwin MG. Persistent pain in patients following scoliosis surgery. Eur Spine J 2007; 16(10): 1551-6.

Yuen VMY, Irwin MG, Hui TWC, Yuen MK, Lee LHY. A double-blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg 2007; 105(2): 374-80.

Caves ND, Irwin MG. Attitudes to basic life support among medical students following the 2003 SARS outbreak in Hong Kong. Resuscitation. 2006; 68(1): 93-100.

Cheung RW, Irwin MG, Law BCW, Chan CK. A clinical comparison of the FlexibladeTMand Macintosh laryngoscopes for laryngeal exposure in anesthetized adults. Anesth Analg 2006; 102(2): 626-30.

Fielding R, Irwin MG. The knowledge and perceptions of nurses and interns regarding acute pain and postoperative pain control (Research dissemination report – nursing studies). Hong Kong Med J 2006; 12(2-S1): 31-4.

Greenland KB, Ha ID, Irwin MG. Comparison of the Berman intubating airway and the Williams airway intubator for fibreoptic orotracheal intubation in anaesthetised patients. Anaesthesia 2006; 61(7): 678-84.

Irwin MG. "NSAIDs - can't live with them… can't live without them". European Society of Anaesthesiology Newsletter 2006; 26(Spring): 10-11.

Kan ASY, Caves ND, Wong SYW, Ng EHY, Ho PC. A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination. Hum Reprod 2006; 21(10): 2606-11.

Liu CL, Fan ST, Lo CM, Wei WI, Chan SC, Yong BH, Wong J. Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center. Ann Surg 2006; 243(3): 404-10.

Ng JKF, Yuen TST, Ng VMW. A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia. J Clin Anesth 2006; 18(3): 205-10.

Wong AYC, O'Regan AM, Irwin MG. Total intravenous anaesthesia with propofol and remifentanil for elective neurosurgical procedures: an audit of early postoperative complications. Eur J Anaethesiol 2006; 23(7): 586-90.

Yuen VMY, Hui TWC, Irwin MG, Yuen MK. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anaesthesia: a double-blinded randomized controlled trial. Anesth Analg 2006; 106(6): 1715-21.