MBBS (HK); MD (HKU); FHKCA; FHKAM(Anaesthesiology); FANZCA; FHKCA(Pain Med)

Interim Chairperson

Clinical Associate Professor


Office : K424, Queen Mary Hospital

E-mail : wongstan@hku.hk

HKU Researcher Page : rp01789

ORCID : orcid.org/0000-0002-8763-5687

RESEARCH INTERESTS

• Clinical pain medicine
• Basic pain signaling pathways

POSITION AVAILABLE

We are looking for competent and motivated PhD students and Research Assistants to join our research team. Our research area is on translational pain research and pain signaling mechanisms. They should have relevant research experience in cell and molecular biology, and be able to take up new techniques (including animal pain models).

Interested candidates are welcome to contact wongstan@hku.hk

SELECTED PUBLICATIONS

• Cheung YT, Wong SSC*. Dexamethasone reduces postoperative pain while delays wound healing in an animal model: Involvement of the NLRP3/Caspase-1/IL-1β pathway. BMC Anesthesiol. 2026 Mar 26;26(1):282.
• Zhang A, Han R, Han K, Li T, Zhu J, Wang Y, Zhou J, Chen J, Shangguan W, Wong SSC, Xia W, Chen G, Xia Z. Propofol and Salvianolic Acid a Synergistically Attenuate LPS-Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1/HMGB1 Pathway. Mediators Inflamm. 2026;2026(1):e6298056.
• Ho HC, Bai W, Wong SS, Cheung CW. A lesson for post-COVID healthcare: assessment of physical and psychosocial risk factors on perceived pain intensity among urban individuals.  Front Psychol 2025; 15: 1447168.
• Huang Y, Ma G, Xie S, Wei R, Liu Y, Zeng Y, Zhao Y, Wang Q, Yang L, Huang H, Hao L, Zhao X, Wang H, Shen W, Wong SSC, et al. SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice. Nat Commun. 2025 Aug 5;16(1):7225. 
• Lai FTT, Tian W, Hu Y, Wei C, Sun Q, Song S, Zhou L, Wei Y, Luo S, Ng APP, Chan JKN, Lo HKY, Chan EWY, Wong SSC, Chang WC. Incidence of gynecological cancers following prolactin-increasing antipsychotic use: a population cohort study. World Psychiatry. 2025;24(3):447-448. 
• Ma CW, Ng OCL, Chan SL, Chu JKP, Sin SWC, Wong SSC. Effect of lecture-related journal articles on medical students’ motivation to learn biomedical sciences. Discov Educ 4, 300 (2025).
• Ma L, Li X, Meng F, Wong SSC, Wang F. Pediatric thoracic spinal Ewing sarcoma/primitive neuroectodermal tumor: a case report and literature review. Front Pediatr. 2025 Dec 16;13:1603099.
• Shing CH, Wang F, Lam PM, Tsui OWK, Chan TCW, Wong SSC*. Addition of liposomal bupivacaine in brachial plexus blocks: a systematic review and meta-analysis of randomized controlled trials. Reg Anesth Pain Med. 2025 Jul 23:rapm-2025-106583. 
• Shing CH, Wang F, Lau LNL, Lam PM, Ho HC, Wong SSC*. Skeletal muscle relaxant for the treatment of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. Reg Anesth Pain Med. 2025 Dec 5;50(12):937-947.
• So HY, Wong SSC, Wai AKC, Chan AKM, Cheng BCP. The complementarity of quantitative and qualitative methods: evaluating educational activities using mixed methods. Hong Kong Med J. 2025 Dec;31(6):416-418. 
• Wang F, Meng F, Chan TCW, Wong SSC*. Platelet-Rich Plasma for Treating Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Pain Ther. 2025 Aug;14(4):1169-1188. 
• Wang F, Meng F, Wong SSC*. Predicting the risk of lumbar prolapsed disc: a gene signature-based machine learning analysis.  Pain Ther 2025; online ahead of print.
• Wong SSC*, Wang F, Fang CX, Chan TCW. Analgesic effect of liposomal bupivacaine: reply.  Anesthesiology 2025; 142(5): 966-7.
• Chan TCW, Wong JSH, Wang FF, Fang CX, Yung CS, Chan MTK, Chan WSH, Wong SSC.   Addition of liposomal bupivacaine to standard bupivacaine versus standard bupivacaine alone in the supraclavicular brachial plexus block: a randomized controlled trial.  Anesthesiology 2024; 141(4): 732-44.
• Chen YL, Feng X, Tam K, Fan C, Cheung MP, Yang Y, Wong SSC, et al.   Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury.  NPJ Regen Med 2024; 9(1): 13.
• Mu J, Xiong S, Yang G, Wang F, Li X, Gao Q, Niu Q, Wong SSC, et al.  Lumbar epidural versus caudal epidural for postoperative analgesia after lower extremity osteotomy surgery in pediatric patients with osteogenesis imperfecta: a propensity-matched cohort analysis in a single-center over 9 years.  J Pain Res 2024; 17(5): 2645-56.
• Shing CH, Wang F, Lau LNL, Lam PM, Ho HC, Wong SSC*. Skeletal muscle relaxant for the treatment of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials.  Reg Anesth Pain Med 2024; 2024 Nov; rapm-2024-105776.
• Tsui FPY, Wong SSC, Chan TCW, Lee Y, Cheung CW.  A validation study of the Cantonese Chinese version of short form McGill pain questionnaire 2 in Cantonese-speaking patients with chronic pain in Hong Kong.  Pain Pract 2024; 24(3): 449-57.
• Yu J, Wong S, Lin Z, Shan Z, Fan C, Xia Z, et al.  High-frequency spinal stimulation suppresses microglial Kaiso-P2X7 receptor axis-induced inflammation to alleviate neuropathic pain in rats.  Ann Neurol 2024; 95(5): 966-83.
• Zhu P, Song Z, Wong SS, Zheng Y. Quantitative neuromuscular monitoring with train-of-four ratio using sonomechanomyography (SMMG): Toward more sensitive evaluation of neuromuscular blockade.  Rev Sci Instrum 2024; 95(12): 123701.
• Wong SSC*, Wang F, Chan TCW, Cheung CW.  The analgesic effect of total intravenous anaesthesia with propofol versus inhalational anaesthesia for acute postoperative pain after hepatectomy: a randomized controlled trial.   BMC Anesthesiol 2023; 23: 112.
• Wong SSC*, Chan TH, Wang F, Chan TCW, Ho HC, Cheung CW.  Analgesic effect of buprenorphine for chronic noncancer pain: a systematic review and meta-analysis of randomized controlled trials.   Anesth Analg 2023; 137: 59-71
• Wang F, Cheung CW, Wong SSC*.  Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia.  Front Genet 2023; 14: 1026672.
• Liu J, Wong SSC*.  Molecular mechanisms and pathophysiological pathways of high-fat diets and caloric restriction dietary patterns on pain.   Anesth Analg 2023; 137: 137-52.
• Leung SYD, Meng F, Liu J, Liu AJ, Ng HLL, Cheung CW, Wong SSC*.   Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling.   Mol Pain 2023; 19: 17448069231185232.
• Ho HC, Wong SS, Cheung CW.  Individual-level and neighborhood-level shifts in mortality patterns among drug poisoning deaths in a high-density Asian city: a territory-wide, case-only analysis.   Int Health 2023. 15(6): 715-22.
• Fan T, Yu Y, Chen YL, Gu P, Wong S, Xia ZY, Liu JA, Cheung CW.  Histone deacetylase 5-induced deficiency of signal transducer and activator of transcription-3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy.   Glia 2023; 71: 1099-119.
• Wong SSC*, Choi EKY, Chan WS, Cheung CW.  Propofol total intravenous anaesthesia versus inhalational anaesthesia for acute postoperative pain in patients with morphine patient-controlled analgesia: a large-scale retrospective study with covariate adjustment.   BMC Anesthesiol 2022; 22: 140.
• Gu P, Fan T, Wong SSC, Pan Z, Tai WL, Chung SK, Cheung CW.  Central Endothelin-1 confers analgesia by triggering spinal neuronal histone deacetylase 5 (HDAC5) nuclear exclusion in peripheral neuropathic pain in mice.   J Pain 2021; 22: 454-71
• Wong SSC, Chan WS, Cheung CW.  Analgesic effects of cannabinoids for chronic non-cancer pain: a systematic review and meta-analysis with meta-regression.  J Neuroimmune Pharmacol 2020; 15(4): 801-29.
• Wong SSC*, Chan WS, Fang C, Chan C, Lau TW, Leung F, Cheung CW.   Infraclavicular nerve block reduces postoperative pain after distal radial fracture fixation: a randomized controlled trial.  BMC Anesthesiol 2020; 20(1): 130.
• Wong SSC, Cheung CW.    Analgesic efficacy and adverse effects of Meperidine in managing postoperative or labor pain: a narrative review of randomized controlled trials.   Pain Physician 2020; 23: 175-201
• Chan TCW, Cheung CW, Wong SSC, Chung AYF, Irwin MG, Chan PK, Fu H, Yan CH, Chiu KY.   Preoperative dexamethasone for pain relief after total knee arthroplasty: a randomised controlled trial.   Eur J Anaesthesiol 2020; 37: 1157-67
• Wong SSC*, Leung MYY and Cheung CW.  The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double-blind randomized controlled trial.  Eur J Pain  2019;  23(5): 844-93.
• Wong SSC*, Lee UM, Wang XMA, Chung SK, Cheung CW.  Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.   Neurosci Lett 2019; 709: 134379.
• Wong SSC, Sun L, Qiu Q, Gu P, Li Q, Wang XM, Cheung CW.  Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.  E J Pain 2019; 23(4): 812-22.
• Wong SSC, Qiu Q, Cheung CW.  Segmental spinal myoclonus complicating lumbar transforaminal epidural steroid injection.  Reg Anesth Pain Med 2018; 43(5): 554-6.
• Wong SSC, Choi SW and Cheung CW.  A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour.  PLoS One 2018; 13(10): e0204054.
• Wong SSC, Chan CW, Cheung CW.  Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice.  Hong Kong Med J 2017; 23(5): 517-23.
• Qiu Q, Choi SW, Wong SSC, Irwin MG, Cheung CW.  Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis.  Anaesthesia 2016; 71(10): 1222-33.

HONOUR & AWARD

• ExpertScape, Name Top 1% World Expert in Pain, 2021